This is the report of a well-planned study of 100 cases of atrophic gastritis in Chongqing area including gastroscopic examinations, biopsies, and determinations of the levels of gastric acidity and fasting serum gastrin (FSG) , of the parietal cell antibody (PCA) titer, and of the peripheral blood T cell count (ANAE method) .Atrophic change was limited in the antrum in 89 out of the 100 cases; it involved the antrum and the body of the stomach in lo cases. There was only one case showing distinct atrophic change on ths mucosa of the body and only mild and superficial inflammation in the antrum. The MAO and PAO of the gastric acid of the patients were lower than that of the control group but the difference was not significant statistically (P

A study of the peripheral blood T lymphocytes of patients with chronic atrophic gastritis (mainly of B type) and gastric cancer was undertaken by demonstrating the acid ?-naphthyl acetate esterase in lymphocytes as a T cell marker. A scoring method was also designed by the authors to estimate the esterase activity according to the size and number of the esterase particles. The T lymphocyte levels, i.e. ANAE%, of gastric cancer (46.2?1.87%) and chronic atrophic gastritis (54.4?1.48%) were significantly lower than that of normal controls (72.7?5.9%). The T lymphocyte levels of gastritis patients, however, were significantly higher than that of cancer patients. Based on the above findings, it is suggested that the changes of cell-mediated immunity may play a role in the etiopathogenesis and progression of B type atrophic gastritis.

Selenium is one of the essential trace elements for man. A close relationship between the selenium levels and diseases of human beings exists. The determination of selenium may provide a valuable index in prevention and treatment of human diseases. 3 quantitative control diagrams are used as means of method examination in determination fo selenium. The role of control diagram in determination procedure is discussed.

The relationship between the intestinal metaplasia subtypes and the development of gastric carcinoma (GC) was. investigated with mucohistochemical staining on 576 biopsy specimens taken from patientswith intestinal metaplasia (IM) and 85 specimens taken from gastrointestinal mucosa of normal adults and fetus,IM was classified into 3 types, complete (type Ⅰ) and 2 classes of incomplete (types Ⅱ & Ⅲ) depending on the absence or presence of sulphomucin within the mucin secreting columnar cells. Type III IM was significantly more common in patients with GC and in those with dysplasia than in patients with benign gastric pa,tholgy(P

The expression of gastric carcinoma related antigen was observed in 110 gastrectomy specimens with gastric carcinoma and 343 biopsy specimens with intestinal metaplasia by ABC immunohistochemical staining with MG 7 , a monoclonal antibody against human gastric carcinoma. Intestinal metaplasia was classified into types I, II and III by histochemical mucin stainings. Among the 110 cases of gastric carcinomas, 92 (83.6%) showed the positive reaction for MG 7 related antigen. In different types of intestinal metaplasia, type III (46.7%) exhibited a significantly higher positive rate for MG 7 related antigen than type II (25.6%) and type I (18.6%) (P

Quantitative DNA measurements were done in mitotic figures in cells from early gastric carcinoma of intestinal type(n = 8), slight (n=10), moderate (n=10) and severe dysplasia (n = 8), and simple intestinal metaplasia (n=10). The mean DNA values were found to increase gradually from intestinal metaplasia to early gastric carcinoma, with the sequence of from slight, moderate to severe dysplasia, and the differences between each two adjacent groups being statistically signi ficant (P

The expression of tumor-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3 was investigated in HO resected specimens of gastric carcinoma,36 biopsied specimens of dysplasia,and 303 specimens of intestinal metaplasia(IM).IM was subdivided into complete Type I and incomplete Types Ⅱ and Ⅲ based on whether sulphomucin is present or absent in the mucin secreting columnar cells.The positive rate of TAG-72 in gastric carcinoma was 60.9%,and it was significantly higher in IM specimens with gastric carcinoma than in those with benign gastric lesions (P

The immunohistochemical reactivity of MC3,a monoclonal antibody (MoAb) against human colonic cancer,was studied in 110 specimens with gastric cancer (GC) and 343 specimens with intestinal metaplasia (IM) taken from different diseases,including GC (n=79),dysplasia (n=32),chronic atrophic gastritis (CAG,n=173),gastric ulcer(GU,n=28) and chronic superficial gastritis (CSG,n=31).IM was subtyped into three types:complete (type I) and two classes of incomplete IM (type II and type III) depending on the absence or presence of sulphomucin within the mucin secreting columnar cells.The positive rate of staining with MoAb MC3 in GC was 68.2%.The positive reactivity of MC3 was significantly more common in IM specimens with GC and in those with dysplasia than in those with benign gastric pathology.The positive rate of staining with MC3 in type III IM (48.6%) was significantly higher than those in type I (19.9%) and type II IM (28.0%) (P

Objective To investigate the expression of proapoptotic gene Bax and its association with apoptosis in gastric carcinoma and paracancerous tissues. Method Bax protein expression and the density and distribution of the apoptotic cells in situ in 50 gastric carcinoma and 33 paracancerous tissues were observed using immunohistochemical staining and terminal deoxynucleotidyl transferase mediated nick end labelling(TUNEL)technique.Result The positive rate and staining intensity of Bax protein in paracancerous tissues were significantly higher than that in gastric carcinoma (P0.05 for each),it was strongly associated with intestinal type gastric carcinoma and well/moderately-differentiated gastric carcinoma (P

Patients with Helicobacter pylori (Hp) positive peptic ulcer were randomly treated with Hp-killing or Hp-nonkilling anti-ulcer drugs, and 19 patients with healed peptic ulcer were followed up to determine the relapse rate of peptic ulcer. It was found that there was a close relationship between Hp infection and the existence of active chronic gastritis, and the clearance of Hp infection could not alleviate the activity of chronic gastritis or influence the 3-week healing rate of peptic ulcer. The relapse rate of the Hp-positive ulcer patients was higher than those Hp-negative cases.