Objective To observe the effect of rosiglitazone combined with ethinylestradiol cyproterone on treatment of polycystic ovary syndrome (PCOS).Methods Sixty-eight cases with PCOS combined with insulin resistance (experimental group) and 68 cases with PCOS combined without insulin resistance (control group) were selected.The patients in experimental group were given rosiglihtazone combined with ethinylestradiol cyproterone,the patients in control group were not given rosiglitazone.The level of seurm adiponectin and lepfin was measured before and after treatment in two groups,body mass index (BMI),Homeostasis model assessment of insulin resistance index (HOMA-IR) was calculated before and after treatment in two groups,and drug adverse reaction was observed.Results There was no significant difference in serum adiponeetin,leptin,BMI before treatment between two groups (P ＞ 0.05).HOMA-IR in experimental group was higher than that in control group (3.90 ± 0.87 vs.2.15 ± 0.62),and there was significant difference (P ＜ 0.05).BMI,leptin after treatment in experimental group and control group was decreased compared with that before treatment [experimental group:(25.41 ± 1.01) kg/m2 vs.(30.11 ± 1.51) kg/m2,(0.25 ± 0.08) μ g/L vs.(0.44 ± 0.11) p g/L; control group:(26.68 ± 1.12) kg/m2 vs.(30.55 ± 1.42) kg/m2,(0.23 ± 0.1 0) μ g/L vs.(0.39 ± 0.23) μ g/L],adponectin was increased compared with that before treatment [experimental group:(1.39 ± 1.10) μ g/L vs.(0.89 ± 0.15) μ g/L;control group:(1.42 ± 1.05) μ g/L vs.(0.91 ± 0.44) μ g/L],and HOMA-IR after treatment (2.09 ± 0.68) in experimental group was lower than that before treatment,and there was significant difference (P ＜ 0.05).There was no significant difference between two groups (P ＞0.05).Experimental group did not appear obvious drug adverse reaction in the process of treatment.Conclusion Ethinylestradiol cyproterone can improve metabolic disorders indicators,PCOS combined with insulin resistance should add rosiglitazone to improve insulin resistance.

As an immune regulator, vitamin D plays a role in asthma. In the fetus, vitamin D participates in immune system and lung development. It has been reported that vitamin D deficiency may explain a portion of the asthma epidemic. Beneficial associations have been reported between vitamin D and asthma severity in children. Epidemiologic studies have also suggested that higher prenatal vitamin D intakes have a protective role against wheezing illnesses in young children. In addition, vitamin D may play a therapeutic role in steroid resistant asthmatics and there is interest in using vitamin D therapeutic-ally to complement conventional asthma therapy, such as specific immunotherapy.

ObjectiveTo study the effect of high-dose mifepristone on the expression of hypoxia-inducible factor 1,(HIF-1α) and vascular endothelial growth factor(VEGF) in the endometrial tissue and research the molecular mechanisms of mifepristone in treat ment of endometrial cancer.Methods30 patients with endometrial cancer who were treated were asked to oral mifepristone 100mg/d,the specimens from a biopsy or curettage were taken as the group before treatment,the specimens from surgery were as the group of after treatment.Another 10 cases of normal endometrium were selected as the control group.The expression of HIF-1α and VEGF were examined with immunohistochemistry.ResultsThe expression of HIF-1 α and VEGF(78.6 ± 3.5,92.4 ± 5.1 ) in endometrial cancer was significantly higher than normal endometrium( 192.3 ± 4.7,178.4 ± 3.3,P ＜ 0.01 ),large doses of mifepristone can significantly reduce the expression of HIF-1 α and VEGF in endometrial cancer issues ( 103.2 ± 4.1,118.3 ± 4.9,P ＜0.05).ConclusionOne of the molecular mechanisms of mifepristone inhibits the endometrial cancer was reduced HIF-1α and VEGF expression.

Alveolar fluid transport is closely associated with neonatal lung development neonatal respiratory diseases,such as wet lung,pulmonary hyaline membrane disease,pneumonia,which are related with decreased lung fluid transport.This review introduces the characteristics of neonatal pulmonary fluid balance,including lung fluid secretion and absorption equilibrium,list clinical factors which can increase pulmonary fluid,explain important lung fluid transport mechanisms and their regulations.Inhaling beta agonists or glucocorticoid is a viable therapeutic strategy.

Survivin is an apoptosis inhibitor and plays an important role in the development and progression of cancer.It is undetectable in normal adult tissues,but has been showed to be overexpressed in various cancers and has been regarded as a marker of malignancy.And the promoter polymorphism of Survivin gene is closely related to risk of cancer and gene susceptibility,this might provide clues for further elucidation of the correlation of risk of cancer and genetic polymorphism,and for diagnosis,prevention and screening of cancer gene.

ObjectiveObserving the distribution and the change of the quantity of SP,VIP in the colon tissue of 'cathartic colon'rats.MethodsWe divided the 32 wistar rats weighted (200 ±10)g into 2 groops randomly:the blank group( n =8) and model group( n =8).we induced the 'cathartic colon'rats with the suspension of dahuang.The blank group were given the distilled water for contrast.After one week during the time Dahuang was stopped.We killed them,measured the carbon powder propulsion rates in the intestine and then took Specimen after the 8 rats were fasted 24 hours as well as the blank group,but water were given.We compared the variation of SP,VIP distribution between two groups.ResultsThe carbon powder propulsion rates in the model group were slower than that in the saline control group.The distribution of SP,VIP are all more than that in the blank group.ConclusionThe distribution of SP,VIP are all more than that in the blank group.

This article discussed the author applied the thought of treatment based on syndrome differentiation that acquisitioned from following the master for many years.The three cases of experience in treating insomnia,welling-abscess of the lung and minor chest bind disease applying classical formulae of Xiaochaihu decoction,Weijing decoction and Xiaoxianxiong decoction separately all get preferable clinical curative effect.

This paper introduces the viewpointins from recent researches about carbohydrate ingestion and mobilization and oxidation of fat during exercise in sports nutrition and interactional influence of carbohydrate and fat metabolism during exercise. Keywords：exercise;carbohydrate;fat;metabolism

Objective To observe the treatment effect of cetylpyridinium chloride gargle on the oral candidi-asis infection.Methods According to the selection of different drugs,88 cases with candidiasis infection were divided into the cetylpyridinium chloride gargle treatment group and the compound chlorhexidine gargle control (control group),44 cases in each group.The oral pain improvement,oral mucosal atrophy,swollen gums bleeding,microscopy positive rate,colony number and patients with oral erythema score,clinical efficacy and adverse reactions were observed and compared in the two groups.Results The total effective rate of the treatment group was 95.5%,which was significantly higher than 77.3% in the control group(χ2 =8.063,P =0.019),and the difference was statistically significant.After treatment,mucosal atrophy and erythema scores of the treatment group were significantly better than control group,and there were statistically significant differences (t =6.142,P =0.033;t =6.554,P =0.044).After treatment,the number of colonies and microscopic examination positive rate of the treatment group were better than those of the control group,and with statistical significance (χ2 =11.596,P =0.019;χ2 =6.994,P =0.031 ). Conclusion Cetylpyridinium chloride gargle in the treatment of oral candidiasis infection disease not only has signifi-cant effect and can effectively reduce the pain of patients with oral,reduce the incidence of adverse reaction,it is safe and reliable,it is worth popularization and application in oral candidiasis.

Dexmedetomidine,a medetomidine D-isomer,is an α2-adrenoceptor agonist with protent sedetation,analgesia and antianxiety effects.It can reduce sympathetic nerve reflex induced by operation and anesthesia,stabilize hemodynamic condition,and exert no inhibition of central respiratory system.Intravenous injection of dexmedetomidine is a commonly used route of administration,mainly for perioperative anesthesia and ICU sedation.Unfortunately,intravenous injection of dexmedetomide is invasive,thus it is not recommended for children.Compared with intravenous medication,non-intravenous use indicates slow but stable onset and wider range of safety,which has good anesthetic effect in perioperative patients or those outside the operating room,especially pediatric patients.Dexmedetomidine by nasal dripping is absorbed into the blood through nasal mucosa,which has immediate effect and high bioavailability.Colorless and tasteless dexmedetomidine provides less nasal mucosa irritation and has good tolerance.This article aims to update and review the safety and effectiveness of intranasal dexmedetomidine in pediatric general anaesthesia.