OBJECTIVE: To estimate the value of nasal endoscopic dacryocystorhinostomy combined image guidance system in treating chronic dacryocystistis. METHOD: Thirteen cases (14 eyes) performed surgeries with nasal endoscopic dacryocystorhinostomy combined image guidance system from January 2010 to August 2013 were retrospectively analyzed. Their clinical data were analyzed and the effect of the surgery was evaluated. RESULT: All patients were followed-up for more than half a year. Of all patients,12 eyes were cured, 2 eyes were improved and 0 eyes were noneffective. The total treatment effectiveness was 100%. There was no complication for all cases. CONCLUSION Nasal endoscopic dacryocystorhinostomy combined image guidance system is an effective and reliable treatment method for chronic dacryocystistis, especially for intraoperative location of lacrimal sac and control of operating process.
Dacryocystorhinostomy ; methods ; Endoscopy ; methods ; Female ; Humans ; Male ; Nasolacrimal Duct ; Nose ; Retrospective Studies ; Treatment Outcome

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) are conveniently cultured and separated in vitro because theirimmunogenicity is low. Therefore, BMSCs are suitable for cell transplantation. Research has shown that BMSCs are potential to repair neurological defect. OBJECTIVE: To determine whether in vitro cultured BMSCs can be transplanted to repair peripheral nerve injury or not, and to investigate its mechanisms. DESIGN, TIME AND SETTING: Randomized controlled animal study This study was performed in Department of Toxicology, Public Health College of Jilin University from March 2006 to March 2007.MATERIALS: Fifty healthy female Wistar rats aging 2 months and six 1-week-old female Wistar rats were used for extraction of BMSCs. Rabbit-anti-nerve growth factor (NGF) monoclonal antibody was provided by Santa Cruz Company. METHODS:BMSCs were separated and cultured with adherent method. In the 3rd generation, BMSCs were preiabeled with bromodeoxyuridine (BrdU) 48 hours before transplantation. Fifty healthy Wistar rats were selected to prepare sciatic nerve crush injury models with clamping method.Subsequently, rats were randomly divided into transplantation group and control group, with 25 rats in each group. Rats in the transplantation group underwent transplantation of BrdU-labeied BMSCs at nerve injured sites; while, the same volume DMEM was injected into rats in the control group. MAIN OUTCOME MEASURES: Injured nerve in the transplantation group suffered from anti-BrdU staining 1, 2, 4, and 6 weeks after surgery. Distal injured nerve in both groups suffered from NGF immunohistochemical staining 1, 2, 4, and 6 weeks after surgery. Image analysis system was adopted to analyze integrated absorbance of positive expression. Gait analysis was performed every week after surgery to measure sciatic nerve function index, and it was also adopted to measure regenerated nerve conduction velocity 6 weeks after surgery. Subsequently, amount and inner diameter of medullated nerve fibers were calculated after luxol fast blue staining, while wet weight of experimental-lateral gastrocnemius muscle and cross section area of muscle fiber were measured at the same time. RESULTS: Fifty rats were included in the final analysis. BrdU-labeled positive cells could be found at injured nerve in the transplantation group 1, 2, and 4 weeks after surgery. Integrated absorbance of NGF protein expression in the transplantation group was significantly higher than that in the control group 1 and 2 weeks after surgery (P < 0.01), but there were no significant differences between the two groups 4 and 6 weeks after surgery (P > 0.05). Sciatic nerve function index in the transplantation group superiorly recovered to that in the control group 3-6 weeks after surgery. Furthermore, 6 weeks after surgery, nerve conduction velocity, amount and diameter of medullated nerve fibers, wet weight and cross section area of gastrocnemius muscle in the transplantation group were significantly higher than those in the control group (P < 0.05-0.01). CONCLUSION: BMSCs can be transplantated into injuried nerve tissue, and promote the recovery of nerve function in the micro-enviroment, improve NGF expression in an early phase may be one of its mechanisms.

Objective To investigate the levels of IL-6 in serum and gastric mucosa of servicemen before and after mili-tary maneuver and their significance .Methods The level of serum IL-6 in 60 servicemen was studied by enzyme-linked immunosorbent assay .The expression of IL-6 in gastric mucosa from the 60 servicemen was detected by immunochemical staining.Results The level of IL-6 in serum of servicemen after military maneuver was significantly higher than that before military maneuver (P<0.01).IL-6 was found to be expressed in the cytoplasm of epithelioglandular cells and also in the cytoplasm of mesenchymal cells .The expression of IL-6 in gastirc mucosa was significantly stronger after military maneuver than before military maneuver (P<0.01).Conclusion IL-6 might be involved in the development of pathological changes in gastric mucosa caused by military stress in troops .Examination of the level of IL-6 in the early stage of military stress might help assess the chance of gastric mucosa lesion and its severity .

Cerebrospinal Fluid Leak ; surgery ; Endoscopy ; Humans ; Iatrogenic Disease ; Male ; Meningocele ; surgery ; Middle Aged ; Nose ; surgery

OBJECTIVE: The role of different local flaps in small external nasal skin defect reconstruction was discussed. METHOD: Forty-two cases of the small size nasal defects (diameter < 2 cm) were repaired with local external nose flap (includes the dorsal nasal flap, nasolabial flap and bilobed flap). The clinical and follow-up data were analyzed of patients with small external nasal skin defects, who accepted different local flaps reconstruction. Dorsal nasal flap, nasolabial flaps (includes island flap, slid flap and axial flap) and bilobed flap were tailored to reconstruct different external nasal defect. Twenty-seven patients were male and fifteen patients were female, the patients' age ranged from 28 to 74 years, the median age was 61 years. Thirty-eight cases resulted from resection of skin malignant tumor and four cases were benign lesions. The diameter of defects was 1-2 cm. The defects were reconstructed by single-stage dorsal nasal flap in 7 cases. There were 30 cases of caudolateral nasal defects were reconstructed by nasolabial flap, single-stage island nasolabial flap in 7 cases, axial flap in 18 cases and slid flap in 5 cases. Superior lateral defects were reconstructed by single-stage bilobed flap in 5 cases. RESULT: All defects were repaired successfully. All tissue flaps survived and had not necrosis. There was no tumor recurrence during 3 months to 2 years follow-up. CONCLUSION The dorsal nasal flap, nasolabial flap and bilobed flap can be used safely and effectively to repair the small external nasal defect and have satisfactory curative effect.
Adult ; Aged ; Dermatologic Surgical Procedures ; methods ; Face ; pathology ; surgery ; Female ; Humans ; Male ; Middle Aged ; Nose ; pathology ; surgery ; Reconstructive Surgical Procedures ; methods ; Skin ; pathology ; Surgical Flaps

Objective To evaluate the curative effect of transcatheter arterial chemoembolization (TACE)combined with Antike in the treatment of primary liver cancer. Methods The data of 72 patients with primary liver cancer(90 lesions in total)admitted to the First Affiliated Hospital of Hebei North University from August 2016 to December 2017 were retrospectively analyzed. All patients were divided into the observa-tion group(n = 36)and the control group(n = 36)according to the therapeutic schedule. The patients in the control group(40 foci)were treated with TACE only,and the patients in the observation group(50 foci)re-ceived TCAE treatment,oral Antike capsules were taken at the same time with the frequency of three times a day,two capsules each time,and six weeks were planned for one treatment cycle. A total of four cycles were completed. All patients underwent CT enhancement scans one week before TACE treatment and six months after treatment. According to Response Evaluation Criteria in Solid Tumors,complete remission and partial remission were deemed as effectivity. The imaging data of the change of tumor size,postoperative tumor residual,tumor capsule growth and new intrahepatic metastases were analyzed and used to evaluate the curative effect of patients in the two groups. Results After 6 months of treatment,there were 39 effective lesions in the observation group and 23 in the control group. The total effective rate of the observation group was higher than that of the control group(78. 0％ vs. 57. 5％ ),and the difference was statistically significant(χ2 = 4. 357,P = 0. 037). Twenty-three neoplastic capsule lesions were detected in the observation group and 9 in the control group. The detection rate of neoplastic capsule was higher in the observation group than that in the control group(46. 0％vs. 22. 5％ ),and the difference was statistically significant(χ2 = 5. 356,P = 0. 021). There were 27 residual tumors and 5 new intrahepatic metastases in the observation group,30 residual tumors and 13 new intrahepatic metastases in the control group. The residual tumor rate and neohepatic metastasis rate in the observation group were lower than those in the control group(54. 0％ vs. 75. 0％ ;13. 9％ vs. 36. 1％ ),and the differences were statistically significant(χ2 = 4. 220,P = 0. 040;χ2 = 4. 741,P = 0. 029). Conclusion TACE combined with Antike is safe and effective in the treatment of primary liver cancer. It can improve the total clinical effi-ciency,promote the growth of tumor capsule,and reduce the recurrence rate and metastasis rate of tumor. It is worthy of clinical application.

Objective ToanalyzethecharacteristicmanifestationsandearlydiagnosticvalueofCTinsolitarypulmonarynodules (SPNs)lessthan2cmusing L o g istic regressionanalysis.Methods 156patientswithSPNlessthan2cmconfirmedbypathology werecollected.Statisticalassignment was performed and binary L o g istic regression wasimplemented for CT manifestations.Those features,whichmightbesignsoflungcancer,wereextractedfromtheCTimagesandtheirrisklevelswerealsoanalyzed.Results SixCTsignsincluding "ground-glasssign"(8.12),"lobulationsign"(6.72),"vascularconvergencesign"(6.02),"spiculesign"(5.07),"necrosis and cavitation "(3.41 ),and "vacuole sign (1.02 )" were enrolled in the L o g istic equation.Conclusion "Ground-glass sign "is associated with the highest risk level for lung cancer nodules.T he L o g istic m odel constructed fro m C T m anifestations is helpful for identifyingsolitarylungcancernodules.

OBJECTIVE: To investigate the body sweat,urine excretion and water intake of iron and steel production workers working under high temperature.METHODS: Two hundred and twenty-six workers working under high-temperature were selected as high-temperature group and 39 non-high-temperature workers as control group from an iron and steel production enterprise of Tangshan City by cluster sampling method.The workers working under high-temperature were divided into 4 subgroups(moderate physical labor 30-34 ℃ subgroup Ⅰ,heavy physical labor 30-34 ℃ subgroup Ⅱ,35-39 ℃subgroup and 40-43 ℃ subgroup) according to the labor intensity and the exposure temperature.The wet bulb globe temperature(WBGT) index in workplace was determined.The water intake survey was carried out.Water loss was estimated by body mass difference.The unit of body mass difference before and after work was conversed from kg into mL with formula“1 kg = 1 000 mL”.RESULTS: The water intake was 1 200-4 102(2 456 ± 612) mL in workers working under high-temperature,the drinking amount accounting for 74.5%-80.0% in the total water intake which were 2 004-5 749(3 810 ±672) mL.The difference of body mass before and after work was 1 513-4 932(3 078 ± 662) mL in the hightemperature operation group.The sweat excretion accounted for 86.5% of the total water excretion.In moderate physical labor 30-34 ℃ subgroup I,the total water intake,the body mass difference before and after work,the sweat and the total fluid excretion were higher and the urine excretion was lower than those of control group(P<0.05).The total water intake,the body mass difference before and after work,the sweat and the total fluid excretion in body of heavy physical labor 30-34 ℃ subgroup Ⅱ were higher than those of moderate physical labor 30-34 ℃ subgroup Ⅰ(P<0.05).With the increase of WBGT index,the total water intake,the body mass difference before and after work,the sweat and the total fluid excretion in body of 3 heavy physical labor subgroups increased and their urine excretion decreased which showed a dose-effect relationship(P<0.05).The D-value between the water intake and the sweat excretion of high-temperature operation group workers were-769--322 mL,those between the total water intake and losses were-598--96 mL.CONCLUSION: The fluid intake and excretion in workers working under high-temperature in iron and steel plant are in a negative balance.The water intake is lower than the recommended drinking amount under high-temperature environment.Sweating is the main way of water loss under high-temperature working condition.