1.Jinchang Capsule for type 2 diabetes mellitus of blood-stasis syndrome: a clinical research
Weirong ZHU ; Yonghua YANG ; Lan ZHENG ; Xiaoheng SHEN
Chinese Traditional Patent Medicine 1992;0(10):-
AIM: To study the clinical efficacy of Jinchang Capsule for the treatment of type 2 diabetes of blood-stasis syndrome. METHODS: From JAN.2001 to OCT.2004, 48 cases were divided randomly into two groups.32 cases in the treatment group were treated with oral Jinchang Capsule combined with Western medicine therapy, and 22 cases in the control group were simply treated with Western medicine therapy, with a course of 8 weeks. The changes of clinical symptoms, and fasting blood glucose (FBG), 2 h post prandial glucose(2hFBG), HbAlc, total cholesterol (Tc), triglycerides (TG), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c) levels, and hemorheological parameters were analysed. The safety of the medicine was evaluated also. RESULTS: After treatment, the clinical symptomatic integrals were decreased remarkably in the treatment group (P0.05). There was no significant side-effect in the treatment group. CONCLUSION: The results obtained suggest that Jinchang Capsule can improve the clinical symptomatic integrals and remarkably enhance total clinical efficacy. Combining with the basic Western medicinal treatment of diabetes, it can control the obstinate hyperglycemia, and improve fat metabolism as well as bemorheological parameters. It has indicated that Jinchang Capsule has multipurpose therapeutic actions for diabetes mellitus.
2.Clinical research of intraperitoneal chemotherapy plus Shenmai Injection in treating advanced colorectal cancer.
Weirong ZHU ; Lan ZHENG ; Yuanbiao GUO ; Jianming YUAN ; Xiaoheng SHEN
Journal of Integrative Medicine 2005;3(4):266-9
To study the effects of intraperitoneal chemotherapy (IPC) plus Shenmai Injection (SMI) in treating advanced colorectal cancer following radical resections.
3.Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial
Weirong ZHU ; Shoujie ZHANG ; Dehou DENG ; Xiaoheng SHEN
Journal of Integrative Medicine 2008;6(7):700-3
OBJECTIVE: To observe the clinical therapeutic effects of Dishen Qufeng Decoction (DSQFD), a compound traditional Chinese herbal medicine, in treatment of allergic rhinitis. METHODS: Sixty cases of allergic rhinitis were selected and randomized into DSQFD group (30 cases) and cetirizine group (30 cases), and the patients were orally administered DSQFD and cetirizine respectively. The integrals of patients' symptoms, such as sneezing, nose running, nasal occlusion and nasal itching, signs in the nasal conchae and peripheral blood eosinophil (EOS) count were abserved count before and after treatment. RESULTS: DSQFD obviously improved the symptoms and signs of allergic rhinitis. The total response rate of DSQFD treatment was 83.3%, while that of the cetirizine treatment was 86.7%; the EOS counts in both groups were significantly decreased. These results showed statistical difference between the two groups. CONCLUSION: DSQFD is an effective preparation of traditional Chinese medicine for treating allergic rhinitis.
4.Scorpion venom injection for treatment of cancer pain
Xiaoheng SHEN ; Jianzhong XU ; Weirong ZHU ; Al ET
China Oncology 2001;0(03):-
Purpose:To study the analgesic role of Shikangning(SKN) injection (containing scorpion venom protein) on cancer pain. Methods:In the clinical trial, controls were used(41 cases,who were divided into two groups by the use of randomized double blind methed: SKN group 21 cases and placebo group 20 cases) and the open test (total of 88 cases, 67cases were given drug for 7 days, and 21 cases, for 14 days). Results:In the controlled trial, pain intensity difference(PID) and sum pain intensity difference(SPID) level of SKN group were higher than those in the placebo group ( P
5.Reform on the examination of molecular biology
Chuner CAI ; Weining WU ; Weirong SHEN ; Peimin HE
Chinese Journal of Medical Education Research 2006;0(10):-
To analyse and compare the advantages and disadvantages of various kinds of examinations in teaching molecular biology,and detail the process and effect of thesis proseminar domained examination.
6.COMPOUND MUTATION BREEDING OF KOJIC ACID PRODUCTION STAIN
Weirong SHEN ; Jian SHEN ; Liping HAN ; Ying JIANG ; Yi WAN ; Rui CHEN ;
Microbiology 1992;0(04):-
mutant (UCN 7 17) of producing high yield Kojic acid was screened fr om Aspergillus flavus after treated with UV three times, ? ray of 60 Co one time and NTG four times, underoptimal conditions, the Kojic aci d production level reached up to 6 3% after 7 days, compared with original stains 0 926% The experiments showed that compound mutation using various mutagenic agents ca n alter the original stains sensitivity to mutagenic agents, increase mutation frequency and raise Kojic acid yield
7.Uterine arterial embolization for hysteromyomas: report of 45 cases
Xinbai WANG ; Yuyan SHEN ; Liming LU ; Weirong WAN ; Jinxia LU ; Ruifen MA
Journal of Interventional Radiology 2010;19(4):322-324
Objective To assess the effectiveness of uterine arterial embolization for the treatment of hysteromyomas and to discuss the factors related to the clinical results.Methods Super-selective uterine arterial embolization was performed in forty-five patients with hysteromyomas.Of 45 patients,multiple hysteromyomas were seen in 36 and solitary lesion in 9.The lesion was located at the myometrium in 41 cases,among them coexisted endometrioma was found in 5 cases and coexisted submucosal myoma in 2.The lesion was located submucous layer in the remaining 4 cases.The diagnosis was confirmed by imaging study and gynecological examination.After the operation,ultrasonography and laboratory tests were carried out in all patients to observe the tumor size.hormone levels and hemoglobin concentration.Results A total of 91 uterine arteries were found in 45 patients.including double left uterine arteries in one case.Successful catheterization was obtained in 87 arteries(95.6%).All forty-five patients were followed up for 6-36 months.Six months after the procedure the mean reduction of the tumor size was 69.3%.and the lesion completely disappeared in two cases.In the anemic patients the hemoglobin concentration returned to normal level.The main side-effects included low fever and pain at lower abdomen.Conclusion Uterine arterial embolization is a safe and effective treatment for hysteromyomas.
8.Traditional Chinese medicinal herbs combined with epidermal growth factor receptor tyrosine kinase inhibitor for advanced non-small cell lung cancer: a systematic review and meta-analysis.
Zhongliang LIU ; Weirong ZHU ; Wenchao ZHOU ; Haifeng YING ; Lan ZHENG ; Yuanbiao GUO ; Jingxian CHEN ; Xiaoheng SHEN
Journal of Integrative Medicine 2014;12(4):346-58
Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) targeted treatment has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it is not tolerated well by all patients. In China, some studies have reported that traditional Chinese medicinal herbs (TCMHs) may increase efficacy and reduce toxicity when combined with EGFR-TKI, but outside of China few studies of this kind have been attempted.
9.An epidemical survey of body mass index and obesity among 26558 elementary school children in China
Yi ZHAI ; Chong SHEN ; Weirong LI ; Ming WU ; Qiulan QIN ; Qian HANZHU ; Xiaoming SHI
Chinese Journal of Endocrinology and Metabolism 2013;29(8):669-673
Objective To describe the distribution of body mass index (BMI) and evaluate the prevalence of overweight and obesity among first to sixth graders in 8 Chinese provinces.Methods Data came from the baseline survey of the Chinese Center for Disease Control and Prevention (CDC) funded project Study on Intervention Models for Main Chronic Diseases among children in China.A stratified random cluster sampling strategy was used to select study participants in 8 provinces,including Inner Mongolia,Jiangsu,Anhui,Shandong,Hunan,Guangxi,Gansu provinces,and Chongqing,with diverse geographical and economic level distributions in China.Counties in each province were stratified into three strata according to economic level,and one county was selected systematically from each stratum.In each county,one urban and one rural elementary school were randomly selected ; and in each school,2-3 classes were randomly selected from each of 1-6 grades.All students in these selected classes were invited for participation.Physical examination was performed by trained local CDC staff using standardized instruments to measure height and weight.Overweight and obesity were diagnosed based on the BMI classification standards for Chinese children and adolescents by Working Group for Obesity in China (WGOC).Results A total of 26558(14225 boy,12333 girl) students aged 6-12 years eventually participated in 8 provinces.The average age was 9.3 ±1.8 years old.Mean BMI among boys (17.0 kg/m2) was higher than that among girls (16.4 kg/m2,t =19.60,P<0.01).There were statistically significant differences in mean BMI of each age group of boys and 6-11 age groups of girls between urban and rural regions and among those with three economic levels (P<0.05).The 85th and 95th percentiles of BMI among boys aged 7-11 years in urban region were higher than BMI reference in the standards from WGOC.Lower percentiles were observed among girls aged 7-12 years in rural region.The prevalence of overweight and obesity were 9.3% and 6.5% among schoolchildren aged 7-12 years.The prevalence of overweight among boys (10.9%) was higher than that among girls(7.6%,x2 =88.89,P<0.01) ; while prevalence of obesity were 8.0% among boys and4.7% among girls,respectively (x2 =107.17,P<0.01).The prevalence of overweight was 11.3% in urban and 7.4% in rural children(x2 =131.94,P<0.01).The prevalence of obesity was 8.7% in urban and 4.3% in rural children(x2 =188.99,P<0.01).The prevalences of overweight were 10.3%,8.6% and 9.0% in individuals with high,medium,and low economic levels,respectively(x2 =10.76,P<0.01) ; while the prevalences of obesity were 8.2%,5.6%,and 5.4%,respectively (x2 =51.71,P < 0.01).Conclusions The overall prevalence of overweight and obesity in Chinese school children was high.The prevalence in urban region with high economic level was significantly higher than that in rural region with middle and low economic level.The nutritional and behavioral intervention programs are needed to control the rising trend of obesity in children.
10.Clinical Observations of Treating 40 Cases of Bronchial Asthma with Chuankezhi Injection
Xiaoheng SHEN ; Weirong ZHU ; Jianzhong XU ; Yuanbiao GUO ; Lan ZHENG ; Jing ZHAO ; Xiang XIA ;
Chinese Traditional Patent Medicine 1992;0(01):-
Objective: To prove the clinical therapeutic effect of acute and chronic bronchial asthma with Chuankezhi(CKZ) Injection. Methods: 40 cases of bronchial asthma, including inpatients and outpatients were selected, divided into the attack period group (20) and the relief period group (20). The former was intramuscularly injected CKZ injection 4mL, twice a day, 14 days being a course of treatment. The latter was intramuscularly injected CKZ injection 4mL, twice a day for 15~30 days and 2mL, every other day for 31~90 days; 90 days being a course of treatment. The symptoms and signs, such as asthma, cough, expectroation, pulmonary wheeze were observed. and pulmonary function, absolute eosinophilic granulocyte count and immunogobulin E were measured before and after treatment. Result: By the use of CKZ injection to treat bronchial asthma, the total effective rate amounted to 85% and obvious difference before and after treatment in the two groups ( P