ObjectiveTo observe the clinical efficacy of acupuncture in treating functional dyspepsia due to liver stomach disharmony and its action mechanism.MethodSixty-eight patients were divided into an acupuncture group and a Western medication group by using the random number table, 34 cases in each group. The acupuncture group was intervened by acupuncture [majorly selecting Neiguan (PC6), Qimen (LR14), Zhongwan (CV12), Tianshu (ST25), Zusanli (ST36), Taichong (LR3), and Xingjian (LR2)], while the Western medication group was by using Domperidone tablets, both for 2 weeks. The syndrome score of traditional Chinese medicine (TCM), serum ghrelin content and clinical efficacy were observed before and after treatment for comparison and analysis.ResultThe total effective rate was 91.2% in the acupuncture group, significantly different from that in the Western medication group (P<0.05); after treatment, the TCM syndrome scores decreased significantly (P<0.05) and serum ghrelin contents increased significantly (P<0.05) in both groups; while the improvements were more significant in the acupuncture group (P<0.05).ConclusionAcupuncture is effective in treating functional dyspepsia due to liver stomach disharmony, and its action mechanism is possibly related to the increase of serum ghrelin.

In order to study the changes of main oxidase and antioxidase in the pathological scars,the tissues of hypertrophic scar(10 cases),keloid(10 cases)and normal skin(8 cases)were obtained.The concentration of malonaldehyde(MDA)and the activities of xanthine oxidase(XO),copper,zinc-superoxide dismutase(CuZn-SOD),catalase(CAT)as well as glutathione peroxidase(GPX)were detected by spectrophotometric method.Compared with normal skin tissues,the concentration of malonaldehyde and xanthine oxidase activity were significantly higer in pathological scars(P

Objective To elucidate potential activities of phthalides and terpenoids from Angelica sinensis by theoreticaldocking calculation.Methods Eleven components of phthalides and terpenoids were selected as ligand.Thecrystalline structures of targets related to common diseases were used as the receptors for calculation.Thecalculations were conducted with Schr(o)dinger software package.The grading standard of selectivity was developedaccording to G-score between ligands and receptors.Results Selective targets of phthalides and terpenoids wererelated to nevous system diseases,cancer,pain,diabetes,cardiovascular disease,liver cirrhosis,nephrotic syndrome,inflammatory diseases,rheumatoid arthritis,dermatosis,leukemia,microbial inflections,immune diseases,andhypercholesterolemia.In addition to the medical treatments reported in the literature,our research also indicated thatthese two classes of compounds may be used for tumor,diabetes,rheumatoid arthritis,dermatosis,leukemia,livercirrhosis,and nephrotic syndrome.According to our research,the effects of phthalides and terpenoids may be not sostrong.Conclusion The effects of phthalides and terpenoids on diseases founded through virtual evaluation accord greatly with those reported in experiment and clinic.The combination of computer-aided drug evaluation technique and experiment is definitely an important and fast way to investigate the effects and mechanisms of traditional Chinese medicine.

Objective To explore the investigation method of complicated and profound traditional Chinese herbal medicine,the potential action mechanisms of flavonoids from Scutellaria baicalensis were studied by docking calculation.Methods In total, eight flavonoids (aglycones and their glicosides) from S. baicalensis were selected as ligands.The crystalline structures of targets related to common diseases were used as the receptors for calculation. The calculations were conducted with Schr(o)dinger software package. The grading standard of selectivity was developed according to G-score between ligands and receptors. Results Twenty-six pharmacologic actions have been reported.Among all effects in literature, nine of them can be deduced from the docking calculation of aglycone. From glycosides with grade ++, 25 reported effects can be estimated by calculation. Apparently, the target selectivity of aglycones and their glycosides are different form the virtual evaluation. The virtual evaluation results of glycosides were closer to the reported effects. Conclusion Our proposed virtual evaluation method seems an effective way to investigate the complicated system of traditional Chinese herbal medicine. It suggests that aglycones may be effective as the form of glucoside in vivo, and metabolism is a very important factor for virtual evaluation.

0.05).On 1,3 and 5 days after the operation,the PHS and PVAS of Group B decreased significantly than those of Group A(P

Objective:To investigate the clinical efficacy and patient and partner's satisfaction with penile prosthesis implantation(PPI) for treating Chinese patients with severe erectile dysfunction(SED).Methods:One hundred and sixty-eight SED patients were successfully treated by PPI from July 2000 to June 2010.Of the 146(86.9%) patients who had been followed up over 6 months post-operation,36(24.7%) had been implanted with one piece malleable prosthesis(AMS650) and 110(75.3%) with three piece inflatable prosthesis(AMS700CXM).All the patients had been followed up by using international index of erectile dysfunction(IIEF5),Quality of Life Score(QOL) for evaluating clinical efficacy and using Visual Analogue Scale(VAS) for evaluating patient and partner's satisfaction and the duration of the follow-up was 6 to 119 months.Results:The mean age of patients was 35.9?12.1 years(20 to 75 years),All the operations were successful and sexual intercourse with PPI was performed post 4 to 6 weeks without severe complications like infection and erosion.The prosthesis survive rate and frequent sexual intercourse rate were 98.6% and 87.7% respectively.IIEF5 scores pre and post PPI were 6.3?1.7 and 21.3?1.6 respectively,the QOL scores pre and post PPI were 5.1?0.9 and 1.5?0.5 respectively,and both of them showed significant improvement(P

The lymphatic system plays an important role in the humoral circulation, immune activity and cancer metastasis, but the morphological characteristics of this system have to be studied thoroughly in order to adapt to the modern medicine development. Lymphatic vessels are hardly observed in general cadaveric dissection since their channels are tiny and transparent. Therefore, the improvement of the inspection techniques is the key factor for further study of the lymphatic system. In the early stage of lymphatic study, the researchers could only observe the distribution of the lymphatic vessels and nodes of the mesentery, chyle cistern and thoracic duct in postprandial mammals by anatomic dissection, but were unable to investigate the entire system of the body. Great progress in the study has been made with utilizing the direct lymphatic perfusion with mercury as a medium. Then, because of the toxicity of mercury, it was replaced by indirect injection with other instances, like dye, ink, radioisotope etc, which helped achieving rapid progress in the anatomic study and clinical application. The knowledge of the lymphatic system of the body in existing textbooks is largely based on the early anatomical studies, but quite often it does not explain some of the unexpected clinical findings. In early 2000s, a modified method of lymphatic perfusion has been applied for investigating the human lymphatic system. It has been confirmed that there could be significant differences in the lymphatic distribution of individuals. This paper reviews the current investigative approaches of lymphatic distribution of the upper extremity, from a historical perspective.