Objective:To study the pathological characteristics of columnar alteration with prominent snouts and secretions (CAPSS) and its relationship with incidence of breast carcinoma. Methods: One hundred forty-four CAPSS specimens identified by breast core needle biopsies (CNB) were retrospectively evaluated. The CAPSS specimens were subdivided into lesions with (n=108) and without (n = 36) atypical ductal hyperplasia and their pathological findings were compared. Results: In situ and invasive carcinomas were found in 21. 5% (31/144) of the specimens, including those with and without atypical hyperplasia. We also found that specimens with atypical hyperplasia had a higher malignant incidence than those without atypical hyperplasia (P = 0. 001). Conclusion: CAPSS, especially when with atypical ductal hyperplasia, are associated with breast carcinoma.

The ADAMs(a disintegrin and metalloproteinase) are a family of transmembrane or secreted proteins with important roles in cell fusion,adhesion,degradation of extracellular matrix,proteolysis,and signaling.The most important domains of ADAMs includes metalloprotease domain and disintegrin domain.Some ADAMs have been observed in gastric and colorectai cancer,and produced a marked effects during the tumor development and metastasis.The further research of ADAMs may provide more choices for tumor target therapy.

Transforming growth factor beta1 (TGF-β1) is the product and adjusting factor of the hepatocyte immune process when Hepatitis B virus (HBV) invades. There was a correlation among the level of TGF-β1, immune cell cytokines and HBV replication during antiviral therapy. It has an important clinical significance for the researchers to investigate dynamic change of TGF-β1 in chronicviral hepatitis type B (CHB) immunological response and antiviral treatment.

Male Sprague~Dawley rats were pretreated with phenobarbital and randomly divided into 6 groups and were exposed to O2,/N2/l. 2 MAC anesthetics for I hr; NC, 21 % O2/79% N2; HC, 14 %O2,/86%N2; NH, 21 %O2/79% N2/l. 2 MAC halothane;HH, 14 %O2/86 %N2/ 1. 2 MAC Halothane; NS, 21 %O2/79%N2/ 1. 2 MAC sevoflurane; HS, 14 %O2/86 %N2/ 1. 2 MAC sevoflurnae. Liver specimens andblood were taken 24 hrs after exposure. Thenecrosls and denaturatlon of hepatocellularwere quantltatlvely estlmated by stereoscopy.Ultrastructural morphology was analysed by computer. The liver ofall rats given halothane (14%O2) had extensive centrilobu- lar necrosls and denaltlration. There were an increase in serum glutamic pyruvic transmi- nase accompnaying the morphologic damage。No marked hepatotoxicity was foundin the rats following sevoflurane expoure compared with controls. Hypoxia was the main cause of swelling of mltochondria. Results suggest that sevoflurane has less hepattc injtry than holotnane.

To clarify the difference between benign and malignant tumours of tongue on the PC-NA expression and AgNOR c0unts. Methods: Immunohistochemical and AgNOR stainings were carriedout to detect the PCNA expressi0n and to count AgNOR particles in 14 cases of papillomas and 36 cases ofsquamous cell carcinomas of tongue. Results: The positive index(PI) of PCNA was 7. 15 ? 1. 32 in papillo-mas and 24. 28? 2. 47 in squamous cell carcinomas, and there was a significant difference between them. Asignificant difference between low 19. 45? 15. 88, medium 22. 5 ?18. 79 and high grade carcin0mas 65. 3 ?17. 39 was also observed. The AgNOR counts were higher in squamous cell carcinomas 4. 76 ?1. 59 than inpapillomas 2. 16 ? 0. 33. There was no difference of AgNOR counts in high, medium and low grade ofsquamous cell carcinomas. Conclusion:The PCNA expression and AgNOR counts may be related to activi-ty of cell proliferation and be helpful for differentiating benign from malignant tumours of tongue. In addi-tion, the former may be helpful for grading malignancy.

Objective To study the expression of fascin, an actin bundling protein associated with cell motility, and the relationship with ER negative breast carcinoma.Methods Comparasion of the expression of fascin, estrogen receptor (ER) and proliferative cell nuclear antigen (PCNA) determined by immunohistological method was made on 84 specimens of primary breast carcinomas. Results The diffuse staining of fascin in cancerous cell cytoplasm was noted. Only 3 of 53 breast carcinomas with ER positive showed fascin positive expression (5.67%); in contrast, 21 of 31 carcinomas with ER-negative showed positive expression(67.7 %) (P

Objective: To investigate the expression of suppressor of cytokine signaling 2 (SOCS2) in breast carcinoma tissues and to discuss its relationship with clinical pathological data of breast carcinoma patients. Methods: The tissue microarray for 171 cases of breast carcinoma specimens, 18 adjacent tissues and 20 breast benign lesions were established. Then the expression of SOCS2, ER, PR, cerbB2, p53 and Ki-67 was detected by tissue microarray technique and S-P immunohistochemistry. Results: Positive rates of the SOCS2 protein in the breast carcinoma specimens, adjacent tissues and breast benign lesion were 57. 89% (99/171), 94. 44% (17/18), and 75% (15/20), respectively. The expression of SOCS2 was significantly different in breast carcinoma tissues of different TNM classification, different histological grades, and with or without Ki-67 expression and lymphatic metasrasis(P

Objective To observe the efficacy of 3-dimensional image recombinant guidance in treatment of portal hypertension.Methods A total of 73 cases of portal hypertension were randomized into study and control groups: In study group(n=37),3DCT or MRA imaging display of whole portal venous system was used as guide in selecting portoazygos vein disconnection(P-AVD) operation;in control group(n=36),the classic P-AVD operation was performed.The postoperative complication rate and the degree of amelioration of esophageal varices were cbserved.Results Compared with the control group,the short term rebleeding rate in observation group(0.00%,0/37) was lower than that in control group(11.11%,4/36),improvement rate of esophageal varices in observation group(100%,37/37) was higher than that in control group(86.11%,31/36),and the aggregate rate of portal hypertensive gastric disease and esophageal varices in observation group(0.00%,0/36)was lower than that in control group(13.9%,5/36).There was a statistical difference between the two groups(all P

Nuclear DNA content in 103 cases of malignant and benign breast tumours were determined by means of flow cytometry. It was found that DNA in all the benign lesions showed diploids. In contrast, only 32.3 percent of the cancers had diploids, while 62.3% had additional DNA aneuploids including near-diploids (18.4%); triploids (22.3%); and tetraploids (8.2%) etc. Both the cellular proportion in S-phase and DNA index were significantly higher in malignant breast tumours than those in benign ones (P0.05). The results indicate that the analysis of DNA content is a useful and objective adjunct in the assessment of proliferative activity and biological behavior on breast tumour.