OBJECTIVETo explore the relationship between changes in ideal cardiovascular health score(ΔICHS) and the carotid intima-media thickness(CIMT) among the middle age and elderly population.

METHODSA total of 5 852 cases were enrolled from 101 510 Kailuan Group employees who participated in the health examination in 2006-2007 and 2010-2011 through stratified random sampling. A total of 5 440 individuals met the inclusion criteria (≥40 years old; no history of stroke, transient ischemic attack, or myocardial infarction). CIMT was measured by ultrasound during 2010-2011 examination. Excluding individuals with incomplete data, 4 367 cases were included for the final analysis. According to the AHA definition of ideal cardiovascular health metric, individual ΔICHS was evaluated and the subjects were divided into 3 groups: group reduced (ΔICHS<0, n=1 355), invariant group (ΔICHS=0, n=1 451) and elevated group (ΔICHS>0, n=1 561). ΔICHS was derived from the difference between 2010-2011 and 2006-2007. Multivariate linear regression and logistic regression analysis were used to analysis the relationship between ΔICHS and CIMT.

RESULTSThe ICHS was 3.03 ± 1.27 in 2006-2007 study population and 3.09 ± 1.40 (P<0.01) in 2010-2011 study population. Multivariate linear regression analysis showed that ΔICHS was inversely related to CIMT. For every 1 score increase in ΔICHS, CIMT decreased by 0.009 mm(B=-0.009, P<0.01). Multivariate logistic regression analysis showed that after adjusting for multiple confounding factors, the risk of CIMT wall thickening was lower in the ΔICHS invariant group (OR=0.73, 95%CI: 0.59-0.91) and in ΔICHS elevated group(OR=0.66, 95%CI: 0.52-0.82) compared to the ΔICHS reduce group.

CONCLUSIONElevated ΔICHS is an independent protective factors of CIMT increase in the middle age and elderly population.

Aged ; Cardiovascular System ; Carotid Intima-Media Thickness ; Humans ; Middle Aged ; Multivariate Analysis ; Myocardial Infarction ; Stroke

Objective: To investigation HER2 status in gastric adenocarcinoma of Chinese and contributing factors to the HER2 expression. Methods: HER2 status of 40 842 gastric adenocarcinomas and clinical data were retrospectively collected from 23 hospitals dated from 2013 to 2016. The association between HER2 positivity and clinicopathologic features was analyzed. Results: Of the 40 842 patients the median age was 62 years, the male female ratio was 2.6∶1.0. The rate of HER2 positivity was 8.8% (3 577/40 842). HER2 expression was related to the tissue type, tumor location, Lauren classification and tumor differentiation (P values: 0.009, 0.001, <0.01 and <0.01, respectively). Different HER2 expression status was observed between primary and recurrent tumors in 7.6% (48/635) cases. The rates of HER2 positivity ranged from 2% to 10% among different institutions. The rates of HER2 FISH amplification were dramatically different among the 23 hospitals (0-100%) with an average rate of 10% (810/8 156) in patients with HER2 IHC 2+ . Conclusions HER2 expression is associated with clinicopathologic characteristics. HER2 re-assessment of tumor tissue and use of in situ hybridization techniques increase HER2 positivity. The current retrospective study should reflect the HER2 status in gastric adenocarcinoma of Chinese patients.