Objective To investigate the antibiotic resistance rate of Helicobacter pylori,and to provide reliable evidence of choosing optimal drugs for clinical therapy.Methods Overall 3304 patients were enrolled from February 2006 to March 2007 who accepted gastroscopy followed by Helicobacter pylori culture of the gastric mucosa from biopsy.The antimicrobial susceptibilities of Helicobacter pylori strains for six antibiotics including metronidazole,amoxicilin,gentamycin,levofloxacin,furazolidone,clarithromycin were observed by Kirby-Bauer disk diffusion test.Results 1171(35.4%)biopsy clinical specimens were proved to be Helicobacter pylori positive when cultured in vitro and identified by conventional assays.The metronidazole resistance rate(99.32%)of Helicobacter pylori was significantly higher than that of any of the other 5 antibiotics,and the levofloxacin resistance rate(0.51%)was the lowest.Furthermore there were no significantly change in the tendency of resistance rate for the two above antibiotics from February 2006 to March 2007.However,Helicobacter pylori was resistant to amoxicilin,gentamycin,furazolidone,clarithromycin,and the resistance rate was 61.06%、4.78%、21.35% and 39.45% respectively.Meanwhile,the resistance rates corresponding to four antibiotics were different obviously.Conclusions With the application of antibiotics for Helicobacter pylori eradication,the antibiotic resistance rate increased perceptibly.The rate of resistance to metronidazole appeared to be the highest among six antibiotics applied to clinical treatment.Drug susceptibility testing was valuable to eradicate Helicobacter pylori in clinical therapy.

Objective To study the clinical features, laboratory index and therapy of hypoplastic myelodysplastic syndrome. Methods 8 patients with hypoplastic MDS by using the method of bone marrow smear and bone marrow biopsy were studied. T lymphocyte subsets were analyzed by flow cytometry. 8 patients were treated with personalized therapy. Results All the patients of this group had hypoplastic bone marrow with more than two parts, bone marrow hypocellularity and characteristics of ineffective hematopoiesis. The analysis of T lymphocyte subsets showed that 5 of 8 patients had abnormal CD+4/CD+8 ratios. After personalized treatment, there were 2 obvious remission cases, 3 partial remission cases, 2 progression cases and 1 inefficacy case. Conclusion Hypoplastic MDS is characterized by bone marrow hypocellularity and ineffective hematopoiesis, which showed immunological abnormalities. Personalized therapeutic strategy may prolong survival in patients with hypoplastic MDS.

Objective: To study the morphologic and functional changes of the valve after tricuspid valve prosthesis. Methods: Sixty five patiens whose ages averaged (44.6?10.6) years underwent valve replacement and tricuspid value reconstruction. Color Doppler echocardiography were performed before and after operation. Results: Follow up averaged 12 months after operation, the morphology of tricuspid valve was normal. The diameter of the annulus decreased to (2.2?0.2) cm ( P

Objective: To evaluate the surgical results of aortic valve replacement with autologous pericardial valve. Methods: Nine patients underwent aortic valve replacement with autologous pericardial valve were studied by color Dopplor echocardiography (HP 1000 type). The mobility, thickness, opening amplitude, valve orifice areas, regurgitant stroke volume and transorifice pressure gradient of the autologous pericardial valves were measured and analysed intraoperatively and postoperatively. Results: 10 days postoperation, there was no significant difference in above mentioned indices between patients and normal group. Two years after operation, the mobility, thickness, opening amplitude, valve orifice areas, regurgitant stroke volume and transorifice pressure gradient of the autologous pericardial valves showed no significant changes, the EDV and LVEDD significant reduced as compared with 10 days postoperatively. Conclusion: Two years after operation, the structure and function of the autologous pericardial valve may maintain good condition.

Basic medical theory integrating with clinical practice is the motivation of medical development.In our country,basic medical theory research levels has been low because of mismatch between clinic practice and basic research in lots of affiliated hospitals of medical colleges.In this paper,according to analysize the basic medical research status of several affiliated hospitals of Shantou University Medical College,we think that it is key for enhancing basic research levels to strengthen building clinical research platform,standardize management of scientific research and guide medical staffs carrying out basic theory research from clinic practice.

Through the collection of Practice of acupuncture and moxibustion written by CHEN Jingwen, the acupuncture master in the Republic of China, the academic characteristics on acupuncture and moxibusiton were analyzed. The literature comparison method was adopted to compare the works of LUO Zhaoju, ZENG Tianzhi and LI Wenxian, etc. at the same period. It was discovered that CHEN Jingwen was the medical master who systematicly brought up the theory of acupoint properties earlier in the modern times. Classifying drugs based on acupoints was his academic feature. Additionally, the compatibility therapy of Chinese medicine was introduced to explain the essential ideas on the acupoints combination. The treatment was determined on the basis of zangxiang theory and the reinforcing and reducing therapy of acupuncture was emphasized in the determination of treatment and prescription. CHEN Jingwen's theory of acupoint property had been stressed and spread among the medical scholars in the Republic of China and he had made the beneficial exploration for the development of modern acupuncture and moxibustion therapy.
Acupuncture ; education ; history ; Acupuncture Therapy ; history ; Books ; history ; China ; History, 20th Century ; Humans ; Moxibustion ; history

Environmental endocrine disrupting chemicals (EDC) may interfere with thyroid function by affecting the synthesis,release,transport,metabolism,and clearance of thyroid hormone as well as its receptor binding,etc.Thyroid hormones are essential for normal fctal brain development and for many aspects of normal adult physiology.This paper is to provide a brief overview of recent findings on thyroid disruptionly EDC.It would contribute to the development of new strategies against thyroid dysfuction.

AIM:To investigate the efftct of Gypenosides on contraction of isolated duodenum smooth mustle of rabbits.METHODS:The routine experimental method of isolated duodenal smooth muscle of rabbits were used.The contraction curves of isolated duodenum smooth mustle before and after administration of different concentrations of Gypenosides(0.01%-1.00%)were recorded by Medlab biological information collecting system.RESULTS:Different concentrations of Gypenosides significantly reduced the contraction amplitude of isolated duodenum smooth mustle of rabbits,and showed a dose-dependent relationship.CONCLUSION:Gypenosides can inhibit the contraction of isolated duodenum smooth muscle of rabbits.

Objective To investigate the effects of peroxisome proliferator activated receptor γ(PPARγ) agonists pioglitazone combined with radiotherapy on colon carcinoma xenograft in mice.Methods The colon cancer cells CT26 of mouse were inoculated in the right side of the rib loins of BALB/c mouse.Established BALB/c mice tumor models.The mice were randomly divided into six groups:untreated group,tumor contral group,DMSO group,pioglitazone treated group,radiotherapy group,radiotherapy combined with pioglitazone treated group.To observe the tumor growth of each group,to compute and compare to the tumor inhibition rates.the pathological varieties of the tumor were observed.Results The tumor volumes were compared with each group after two weeks of radiotherapy.Compared with tumor contral group,pioglitazone treated group,radiotherapy group and radiotherapy combined with pioglitazone treated group could decrease the volume of tumor (P =0.008,P =0.001,P =0.001).Compared with pioglitazone treated group,the effect of radiotherapy group or radiotherapy combined with pioglitazone treated group was more evident (P =0.026,P =0.018).Contrasted with radiotherapy group,radiotherapy combined with pioglitazone treated group had no significant difference (P =0.335).The tumor inhibition rates of pioglitazone treated group,radiotherapy group and radiotherapy combined with pioglitazone treated group were 46.30 ％,68.60 ％ and 70.01％.The pathological varieties of tumor were obvious.Conclusion Pioglitazone,radiotherapy and radiotherapy combined with pioglitazone could inhibit the growth of tumor.PPARγ is a new target for tumor treatment.