ObjectiveTo investigate the clinical effect of carvedilol in the treatment of chronic heart failure patients with arrhythmia.Methods120 cases of hospitalized cases of cardiology were randomly divided into treatment and control groups by checking the random number table.The control group was given benazepril hydrochloride combined digoxin cardiac medicine and furosemide or hydrochlorothiazide,spironolactone and other diuretics in the treatment.The treatment group was given carvedilol based on the treatment of the control group.Followed up for 12 weeks,the clinical manifestations,blood pressure and heart rate,left ventricular ejection fraction(EF) and arrhythmias before and after treatment were obsered,and to determine the efficacy.ResultsThe treatment group decreased heart rate,corrected ventricular premature contraction,ventricular contraction and ventricular tachycardia in comparison with the control group with significant differences(t =6.018、5.319、7.623、6.194、7.562,all P ＜0.001 ),and there was a significantly statistical significance( P ＜ 0.01 ) that the treatment group can increase the ejection fraction compared with the control group.The markedly and total efficiency was more effective in the treatment group than the control group,which was statistically significant(x2 =34.301,P ＜0.05).ConclusionThere was a positive effect of carvedilol in improving heart function,reduceing arrhythmias and mortality,and reducing hospitalization rate and other aspects.

The process of apoptosis runs through a variety of signal transduction, and is regulated by many apoptosis-related genes. Inhibitors of apoptosis protein (IAPs) are closely related to the infinite proliferation of tumor cells. IAPs including the recently discovered survivin, livin, are closely related to tumors. The anti-apoptotic mechanism is to be further studied.

ObjectiveTo study the value of serum soluble intercellular adhesion molecule-1 (sICAM-1),B-type natriuretic peptide (BNP) and C-reactive protein (CRP) levels detection on assessment of illness in patients with congestive heart failure.MethodsSixty-three patients with congestive heart failure were involved in this study.The levels of serum sICAM-1,BNP and CRP were compared in patients with different NYHA cardiac function classification before and after treatment.ResultsThe levels of serum sICAM-1,BNP and CRP in NYHA cardiac function classification ≥ Ⅲ grade patients were significantly higher than those in NYHA cardiac function classification ＜ Ⅲ grade patients[ (392.6 ± 73.3) μ g/L vs.(212.6 ± 83.4) μ g/L,( 1992.5 ±1173.7) ng/L vs.(512.6 ± 283.2) ng/L,(49.3 ± 33.5 ) mg/L vs.(6.1 ± 3.6) mg/L] (P ＜ 0.01 ).The levels of serum sICAM-1,BNP and CRP after treatment were significantly decreased compared with those before treatment [ ( 168.9 ± 52.5) μ g/L vs.(362.8 ± 123.1 ) μ g/L,(68.6 ± 38.4) ng/L vs.(1470.9± 1460.1) ng/L,(3.6±2.8) mg/L vs.(34.1 ±29.8) mg/L] (P ＜ 0.01).Conclusion Serum sICAM-1,BNP and CRP levels are positively related with illness,and serum sICAM-1,BNP and CRP levels may be judged as an index assessing treatment effect and prognosis.

BACKGROUND:Fatigue measurement is conducted while the eyes are gazing at something to accomplish the determination and monitoring of a real-time and non-contact fatigue.OBJECTIVE:To figure out the percentage of eyelid closure (PERCLOS)value for fatigue and deduct the subject's fatigue state.DESIGN:To detect the subject's pupils with a reconstructed eye tracking system ,the video frequency of the pupils is collected, from which the PERCLOS value is worked out by image processing. The PERCLOS value is used to reflect the subject's fatigue state.SETTING:School of Mechanical and Electronic Engineering, Beijing Jiaotong University.MATERIALS :The experiment was conducted in the Ergonomics Lab from September 2003 to November 2004. The equipments used were video transmission cable, frame grab card and computer.METHODS:The video frequency images of pupil module sent from eye tracking system were processed to deduct the closure state of the pupil and figure out the PERCLOS value for the determination of fatigue.MAIN OUTCOME MEASURES :The images collected by image collecting card reflected the state of opening and closure of the pupil.RESULTS:A fatigue determination system which was able to determine effectively the examinee's fatigue state was established.CONCLUSION:This new method expands the application of eye tracking system which can be safely used off-line or on-line.

The emergence of drug resistance mutations in human immunodeficiency virus (HIV) genome is the major reason for antiviral treatments failure.To investigate the drug-resistance viral quasispecies in HIV-infected individuals and to find out the new drug resistance mutations have significant effects on directing effective clinical treatment and developing novel antiviral drugs.HIV drug resistance tests mainly include genotypic drug susceptibility assay and phenotypic drug susceptibility assay.We reviewed in this article some novel development in the field.

OBJECTIVE: To investigate the efficacy outcomes of laser assisted outpatient septal spur surgery for contact point pain in a carefully selected group of patients. METHOD: This investigation included 32 patients who were selected for laser-assisted septal spur surgery in an outpatient surgical suite. All had endoscopically visible spur contact as well as nansal CT scans. Patients of sinusitis were excluded. The area of the contact point was treated with decongestant and lidocaine. If the headache completely disappeared or diminished by more than 50% in intensity, subjects were considered candidates for surgery. Headache characteristics were assessed preoperatively and at follow-up (30 months after surgery) using a standardized questionare. RESULT: Nine cases (28.1%) were free from pain at the last follow-up; 19 cases (59.4%) had their headache scores improved after surgery; four cases (12.5%) had a less than 25% reduction in their headache score. No septal perforation, hematoma, was reported. CONCLUSION For selected patients with contact point headaches, septoplasty may be useful. The positive dicaine test may indicate better effect of operation. Laser-assisted outpatient septal spur surgery for contact point pain shows good results in short-term effect, and has less complications, but long-term follow-up is required to assess its real effect.
Adult ; Anesthesia, Local ; Female ; Headache ; etiology ; surgery ; Humans ; Laser Therapy ; Male ; Middle Aged ; Nasal Cavity ; Nasal Mucosa ; surgery ; Retrospective Studies ; Treatment Outcome ; Young Adult

OBJECTIVE To investigate the sterilizing effect of Avagard surgery wasting liquid.METHODS All the staff on operation were divided into two groups at random,each no less than 50 persons.Both groups were sterilized by 4% Avagard surgery washing liquid.In one group,hands and forearms were smeared by 0.5% Avagard fast surgery washing liquid(smearing group),the other group was not smeared by 0.5% Avagard fast surgery washing liquid(no-smearing group).In both groups the samples were derived from fingers and cultured right after sterilization and at intervals of 1h,2h,3h,4h,5h and 6h during operation,and to investigate the sterilization effect.RESULTS The bacteriological detections of both groups in all times showed that the number of colony was0.05).CONCLUSIONS The results of the experiment show that 4% Avagard surgery washing liquid is reliable for its sterilizing effect and easy to use.The duration of antibacterial effect is no less than 6 hours,this method could reduce the cost of the operation and improve the efficiency of work.

OBJECTIVE To investigate the infection rate and observe the healing courses of the incision after the open procedures of the suppurative appendicitis,which was managed by positioning drainage tube under the fatty layer of the incision.METHODS The infection rate,manifestation of the incision,and the mean time in hospital were observed after the drainage tube in the incision was employed.RESULTS The infection rate(9.30%) and the mean time in hospital(6.63?1.95days)dropped significantly(P

Objective To investigate the diagnostic value of combined copeptin, cardiac troponin I (cTnI) and high sen?sitive cardiac troponin T (hs-TnT) in determination of acute myocardial infarction (AMI). Methods A total of 152 patients with AMI were selected as AMI group and 143 healthy examinees during the same period were selected as control group. (1) The levels of copeptin, cTnI and hs-TnT were detected at 0, 4, 6 and 12 h in two groups. (2) The combined detection of cop/cTnI and cop/hs-TnT were studied. The positive rates of these items were evaluated at different time points of AMI. ( 3) The diagnostic sensitivity, specificity and accuracy of different cardiac biomarkers for AMI were compared. Results (1) There were significant differences in copeptin at 0, 4, 6 and 12 h between two groups (P<0.05). There were no significant differ?ences in cTnI and hs-TnT between two groups. (2) cop/cTnI and cop/hs-TnT combined detection showed better positive rates than those of copeptin, cTnI or hs-TnT detection alone. (3) In addition, the combined detection of cop/cTnI and cop/cTnI improved significantly the diagnostic sensitivity of AMI. Compared to cop/cTnI combination, cop/hs-TnT combination detec?tion showed better diagnostic sensitivity, specificity and accuracy for AMI. Conclusion The combined detection of cop/cTnI and cop/hs-TnT are very helpful for early diagnosis of AMI, which shows a very good diagnostic value in clinical application.

Objective To propose a grasp torque control based on experimental learning and haptic feedback to facilitate the manipulator in dexterous manipulation.Methods An experience database was built firstly,and then the object was recognized by tactile feedback in the grasp task.If the object had been experitentially grasped,the torque was output based on the database.In case a new object was grasped,the optimal output torque was calculated by iterative learning.Results The experiment showed that the robot hand could find the experiential output torque quickly when encountering the object in database and calculate the torque by iterative learning to achieve grasp task.Conclusion The experiential database grows up when the robot hand learns more and more experience.It can fast output torque like human in the grasp task.