1.Effect of rapid rehabilitation surgery on the curative effect and pulmonary function of elderly patients with lung cancer
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):438-440
Objective To study effect of rapid rehabilitation surgery on the curative effect and pulmonary function of elderly patients with lung cancer. Methods 240 patients of lung cancer who received therapy from March 2014 to March 2016 in Ningbo Yinzhou People's Hospital were selected as research objects. According to the draw method divided into control group and experimental group, 120 cases ineach group. The control group was treated with routine nursing intervention, while the experimental group was treated with concept intervention of rapid rehabilitation surgery. Then extubation time, exhaust time, antibiotic use time, ambulation time, hospitalization time, lung function index, the MOS item short from health survey (SF-36) and Visual Analogue Scale/Score(VAS ) , adverse reactions rate of two groups were compared. Results The extubation time, exhaust time, antibiotic use time, ambulation time and hospital stay in the experimental group were significantly lower than those in the control group, the difference was statistical y significant (P<0.05); The levels of forced expiratory volume in one second (FEV1), forced vital capacity(FVC), forced expiratory volume in one second(FEV1/ FVC)were significantly higher than those of the control group, the difference was statistical y significant (P<0.05),Psychological quality, role quality, physiological quality and social quality score were significantly higher than those of the control group, the difference was statistical y significant (P<0.05), VAS scores were significantly lower than those in the control group, the difference was statistical y significant (P<0.05). The total incidence of adverse reactions was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion The concept of rapid rehabilitation surgery has significant curative effect on elderly patients with lung cancer surgery, can improve the pulmonary function, reduce the incidence of complications, reduce the length of stay and benefit the prognosis of patients.
2.Clinical observation of nimotuzumab with chemotherapy in metastatic gastrointestinal tumor patients
Min PANG ; Guohua REN ; Yahong SUN ; Weina HE ; Yuji AN ; Jangze XIN ; Weihua ZHANG ; Pengyuan SONG ; Lijun SHENG
Cancer Research and Clinic 2012;24(7):454-456
ObjectiveTo explore the efficacy and toxicity of nimotuzumab plus chemotherapy in the treatment of metastatic gastrointestinal tumor.MethodsObservationgroup 22 patients with metastatic gastrointestinal tumor with confirmed diagnosis,were treated with nimotuzumab in combination chemotherapy.Nimotuzumab was given 200 mg weekly for at least six weeks. Control group 21 patients with metastatic gastrointestinal tumor with confirmed diagnosis were treated with only chemotherapy.ResultsThe effects of observation group could be observed in 22 patients, the rate of response(RR)was 31.8% (7/22), and the disease control rate (DCR) was 72.7 % (16/22).QOL was improved.The effects of observation group could be observed in 21 patients,RR was 14.3 % (3/21),and the disease control rate was 42.8 % (19/21).DCR and QOL improvements were statistically significant different between the two groups.(x2=3.939,x2=4.250,P<0.05).The two groups had no significant difference in RR and toxicity.ConclusionNimotuzumab in combination with chemotherapy is effective and can improve the disease control rate, toxicity, tolerance,quality of life.
3.Exploration of 241Am measurement in fecal samples
Weina SONG ; Yunyun YIN ; Aiyun LI ; Chuangao WANG ; Zhiping LUO ; Hongchao PANG
Chinese Journal of Radiological Health 2022;31(5):542-547
Objective To preliminarily study and establish a method for measurement of the transuranic nuclide 241Am in fecal samples, and to provide technical support for internal radiation monitoring of staff. Methods Fecal samples were collected with a self-made stool sampler and treated with a self-made carbonization and ashing furnace. DGA resin was used to separate and purify 241Am from fecal samples. With 243Am as the tracer, the orthogonal method was used for condition optimization. Results The optimum conditions for separation and purification were: the acidity of HNO3 added into the column, 6 mol/L; column flow rate, 0.6 mL/min; and the volume of analytical solution,12 mL. The method based on inductively coupled plasma mass spectrometry showed a detection limit of 9.79×10−4 Bq for 241Am in fecal samples, which was satisfactory and feasible. Conclusion This method fills the vacancy of 241Am measurement in fecal samples to some extent, which is of practical significance for internal radiation monitoring and protection for analysts.