1.Investigation of possible relationship between three-dimensional radiological localization of herniated lumbar discs and their functional status
Weiming YANG ; Feipeng NING ; Dingkun LIN
Chinese Journal of Orthopaedics 2014;34(3):280-284
Objective This study was designed to describe the localization and the extent of lumbar disc herniations (LDH) by three-dimensional radiological classification and to investigate their potential correlation with symptom and function evaluation.Methods The study retrospectively analyzed 261 patients (284 segments of herniated discs) who were diagnosed with LDH by computerized tomography (CT) or magnetic resonance imaging (MRI) from January 2006 to April 2010.There were 162 males and 99 females,with an average age of 42.1 years old (range,14-67 years) and the mean duration of history is 14.6 months (range,1-38 months).There were 35 cases of heavy manual workers,133 cases of moderate manual workers,and 93 cases of comfortable manual workers.The data were consisted of 188 MRI and 73 CT reports.The three-dimensional radiological classification was applied to describe the localization and the extent of LDH.Oswestry disability index (ODI) scores,Japanese Orthopaedic Association (JOA) scores and visual analogue scores (VAS) were applied to evaluate the vertebral symptom and function.The relationship between three-dimensional radiological classification and their functional status was probed.Results Herniations of lumbar discs located mainly sagittally at Level Ⅰ (151 segments,53.2%) and Level Ⅲ(122 segments,43.0%); horizontally at Area 2 (209 segments,73.6%)and Area 3 (61 segments,21.5%); and frontally at Area b (162 segments,57.0%),Area a (78 segments,27.5%) and Area c (41 segments,14.4%).The ODI scores at visit were 56.91%±13.62%,ranging from 20% to 90%;JOA scores were ranging from 0 to 24 (mean,13.57±4.68); while VAS scores were ranging from 3 to 10 (mean,6.09±1.89).There was no significant difference on ODI scores,JOA scores and VAS scores between different herniation locations.Conclusion According to the three-dimensional radiological classification,most of the lumbar disc herniations located at Level Ⅰ sagittally,Area 2 horizontally,and Area b frontally.Clinical symptoms and lumbar function did not depend on the location of the lumbar disc herniations by the three-dimensional classification.
2.Analysis of DSA for inflammatory pseudotumor of the liver(analysis of 12 cases)
Weiming LEI ; Yi YANG ; Jun ZHOU
Journal of Interventional Radiology 1994;0(04):-
Objective To evaluate the diagnostic and differential diagnotic values of DSA features for inflammatory pseudotumor of the liver(IPL). Methods An retrospectively comparative analysis of 12 hepatic inflammatory pseudotumors confirmed surgicopathologically from May 2002 to March 2007 with DSA features and correlative imaging data were carried out. Results 10 cases consisted of only 1 lesion and other 2 cases with multiple lesions were opacified initially at the late arterial phase,with prominent peripheral ring-like staining at portovenous and parenchymal phases and less dense opacification in the central region; furthermore heterogenous staining occurred in 5 cases. Conclusions DSA is probable the most appropriate method for the diagnosis and differential diagnosis of hepatic inflammatory pesudotumor.
3.Clinical and laboratory study on lactose malabsorption in children
Congmin ZHAO ; Weiming LI ; Ying YANG
Journal of Third Military Medical University 1988;0(05):-
Lactose tolerance test with ethanol(LTTE)described by Arola was performed in 41 healthy children and lactose malabsorption(LM)could be diagnosed if blood galactose(B-gal)was less than 0.3 mmol/L or urine galactose less than 2 mmol/L.Then 138 healthy infants and children and 95 children with acute diarrhea were examined for LM or lactose intolerance(LI)with the urine samples of LTTE and symptom-response score(SRS).It was found that LTTE was reliable in the diagnosis of LM ;the incidence of LM or LI increased with the increase of age in children)and RV enteritis was liable to be complicated with LM or Li.
4.Clinical use of recombinant human growth hormone in aged patients with postoperative fatigue syndrome
Chengyu YANG ; Weiming LI ; Xitu LUO
Parenteral & Enteral Nutrition 1997;0(03):-
Objectives: The aim of this study was to define whether growth hormone therapy would reduce the course of postoperative fatigue (POF) in aged patients (60~80 years old) with nutritional support. Methods: Forty aged patients who underwent partial gastrectomy or other operations were randomized into two groups. All patients were treated with the same nutritional support formula.A group of patients was treated with rhGH for 7 day from the third day after operation, and control group treated with placebo.The score of POF, nitrogen balance, transferrin level and body weight were monitored. Results: Score of POF in rhGH group on day 7 and 14 after operation was lower than that in control group(P0.05). Conclusions: Aged patients with rhGH after major operation can recover more rapidly from POF.
5.The application and one-year follow-up result of sirolimus-eluting stent in diabetic patients with ST-segment elevation myocardial infarction.
Weiming LI ; Xinchun YANG ; Lefeng WANG
Chinese Journal of Practical Internal Medicine 2006;0(13):-
Objective To investigate the feasibility,safety and efficacy of sirolimus-eluting stent implanting in diabetic patients with ST-segment elevation myocardial infarction(STEMI)treated by emergency percutaneous coronary intervention(PCI).Methods One hundred and six diabetic patients with STEMI treated by emergency PCI were included into this study.The incidence of major adverse cardiovascular event(MACE),stent thrombosis and restenosis was evaluated.Results Totally 105 patients were successfully treated by emergency PCI and there were no complication during the procedure.Totally 134 sirolimus-eluting stents were successfully implanted on 110 target lesions.There was one subacute stent thrombosis in 106 patients during one month.One-month follow-up result showed that the MACE was 4.72% and the death rate was 3.77%.The MACE was 10.38% and the death rate was 3.77% one year later.One-year angiography follow-up showed that restenosis rate was 11.54%.Conclusion Implanting sirolimus-eluting stent in STEMI patients during emergency PCI is safe and effective.Sirolimus-eluting stent can reduce restenosis rate and MACE in diabetic patients with STEMI treated by emergency PCI.
6.Anti-asthmatic effect inhibition of artesunate on the asthmatic model of guinea-pig
Maosheng YANG ; Kang HE ; Weiming XU
Chinese Pharmaceutical Journal 1999;(3):160-
OBJECTIVE:To study the anti-asthmatic effects of artesunate on the durg-induced asthmat.METHOD:Drug-induced asthmatic model of guinea-pig. RESULTS:Using nubilous inhalation or intragastric administration,artesunate significantly inhibited the guinea-pig model asthma in a dose-dependent manner.It's ED50 were (99.95±7.69)mg.L-1(n=4) and (15.64±1.25)mg.kg-1.d-1(n=4) respectively. CONCLUSION:artesunate showed anti-athmatic effect in guinea-pig asthmatic model.
7.Detection of HSV2-IgG, HBsAg and HCV in Patients with STD and HIV Infection
Weiming GU ; Mingmin LIAO ; Yang YANG ; Lei WU ; Weizhong HU
Chinese Journal of Dermatology 1994;0(05):-
Objectives To compare the co-infection statues of HSV, HBV and HCV in patients with STD and HIV infection for providing evidence of developing prevention and control strategies. Methods Serum samples confirmed to be infected with HIV/AIDS by Western blot, and serum samples of patients with STDs (syphilis, gonorrhoea and chlamydial infection) were tested for HSV2-IgG, HSV2-IgM, HBsAg and HCV-IgG by ELISA. The detection levels were compared between the two groups. Results Out of 76 specimens in STD group, HSV2-IgG was detected in 24 specimens (31.58%), HSV2-IgM in one specimen (1.32%), HBsAg positive in 8 (10.53%), and HCV antibody positive in 4 (1.32%). In 14 specimens of HIV/AIDS group, HSV2-IgG were detected in 7 (50.00%); HSV2-IgM in 5 (35.71%);8 (578.14%) were positive for HBsAg and 3 (21.43%) for HCV. In a total of 90 specimens, both HSV and HBV were detected in 6 specimens, both HSV-IgM and HBV in 2, and the four above-mentioned antibodies in 2. The infection rates of HSV, HBV and HCV were significantly higher in HIV-infected specimens than those in the STD specimens (P
8.Observation of the effectiveness of rehabilitation after arthroscopic rotator cuff repair
Weiming ZHANG ; Shuai YANG ; Qing XIE ; Jianchun LU
Chinese Journal of Physical Medicine and Rehabilitation 2013;(1):43-46
Objective To discuss the effectiveness of rehabilitation training after arthroscopic rotator cuff repair.Methods Seventy-four cases of arthroscopic rotator cuff repair were studied.They were randomly divided into a treatment group and a control group.Both groups received shoulder passive motion training after the operation.The treatment group also received 3-phase shoulder exercises for rehabilitation.changes in American shoulder & elbow surgeons' scores (ASES scores),University of California at Los Angeles shoulder scoring system scores (UCLASS),and visual analogue scale (VAS) scores were assessed pre-operation,and 6 months and 1,2 and 3 years later.Results There was no difference between the groups pre-operation.After the operation,significant improvements in all the outcome measurements were observed in the treatment group.Significant improvement in VAS scores was observed only in the treatment group.Shoulder pain,mobility,range of active forward flexion,strength of forward flexion and patient satisfaction all improved significantly more in the treatment group than in the control group.Conclusions Early and systematic rehabilitation training is an effective way to improve the function of the shoulder joint after arthroscopic rotator cuff repair.
9.Clinical Observation of Modified Xiaoyao Powder Plus Abdominal Needling for Conducting Fire Back to Its Source in Treating Swallowing Dysfunction in Parkinson's Disease
Xiaoming PAN ; Yuyang BAI ; Xiaoqing YANG ; Weiming WAN
Journal of Guangzhou University of Traditional Chinese Medicine 2017;34(4):538-542
Objective To investigate the therapeutic effects of modified Xiaoyao Powder combined with abdominal needling for conducting fire back to its source for the treatment of swallowing dysfunction in Parkinson's disease, and to explore a more effective therapy for swallowing dysfunction in Parkinson's disease. Methods Forty-two Parkinson's disease patients suffering from swallowing dysfunction were divided into treatment group and control group, 21 cases in each group. The patients in both groups received routine swallowing function training. In addition to the training, the treatment group was treated with modified Xiaoyao Powder combined with abdominal needling for conducting fire back to its source, and the control group was given conventional western medicine of Domperidone and Levodopa Benserazide Hydrochloride. After treatment for 3 weeks, we compared the dysphagia scores and effective rate of the two groups. Results (1) All of the patients in the treatment group completed the trial, but 2 cases of the control group dropped out. Therefore, a total of 40 cases completed the trial. (2) The dysphagia scores of the two groups were much improved after treatment (P<0.01 compared with those before treatment) , and the improvement of the treatment group was superior to that of the control group (P < 0.05). (3) After treatment for 3 weeks, the total effective rate of the treatment group was 95.24% and that of the control group was 52 . 63%, and the difference was statistically significant between the two groups(P<0.01).(4) Gastrointestinal reaction occurred in 3 cases(one from the treatment group and 2 from the control group) , but there were no other side effects found in both groups. Conclusion Modified Xiaoyao Powder combined with abdominal needling for conducting fire back to its source is more effective for the treatment of swallowing dysfunction in Parkinson's disease than routine western medicine treatment.
10.Culture and functional identification of macrophages from human peripheral blood
Weiming LIN ; Ailing DAI ; Huifang YIN ; Xiaoyan YANG
Chinese Journal of Immunology 2015;(1):86-89
Objective:To isolate monocytes from human peripheral blood mononuclear cells( PBMC) ,induce macrophages,and identify the function of macrophages.Methods:Monocytes were isolated from PBMC using magnetic activated cell sorting( MACS) anti-CD14 microbead.Sorted CD14+and CD14-cells were checked by flow cytometer to evaluate the efficiency of sorting.The sorted CD14+cells were cultured in IMDM media with 10%human AB serum and 10 ng/ml M-CSF for 7 days to generate macrophages,which were identified by morphological features and phagocytosis function.Results:A high purity of monocytes was obtained by MACS anti-CD14 microbead.The percentage of CD14+cells was 10% and 85.8% before and after sorting, respectively.The macrophages were approximately 40-45 μm in maximum diameter and had the fried egg colony morphological features after 7 days culture.The lymphoma ( Raji) cells were efficiently engulfed by macrophages.Conclusion: The high purity of CD14+monocytes is isolated from PBMC and monocyte-derived macrophages efficiently engulfed lymphoma cells.