1.Expression and clinical significance of a disintegrin and metalloproteinase-12 and proliferating cell nuclear antigen in bladder carcinoma
Laikun TANG ; Weilong QU ; Feng TIAN ; Zulin WANG ; Li SONG ; Zhongwei YU ; Ke WAND ; Fengjin WU ; Jiping YANG
Clinical Medicine of China 2013;(3):297-299
Objective To investigate the expression of a dismtegnn and metalloproteinase-12 (ADAM12) and proliferating cell nuclear antigen (PCNA) in human bladder carcinoma,and to explore their correlation with different grades and stages of bladder cancer.Methods Biopsies of 12 normal bladder and 43 bladder tumors were performed.And immunohistochemistry was conducted to detect the expression of ADAM12 and PCNA in the biopsies.Results Positive expression signals of ADAM12 were detected significantly higher inthe bladder cancer biopsies than that in the normal ones (Z =4.879,P < 0.05),and the expression level of ADAM-12 in lower histological grade was significantly higher than that in the moderate and higher histological grades (x2 =22.3685,P < 0.01).Positive expression signals of PCNA were detected significantly higher in the bladder cancer biopsies than that in the normal ones (Z =4.879,P < 0.05)).Those with lower histological grade had a higher expression level of PCNA when compared with the moderate and higher histological grades (x2 =10.665,P =0.0137).The expression of ADAM-12 was positively correlated with PCNA in bladder cancer (r =1.000,P < 0.0001).Conclusion The over expression of ADAM12 and PCNA maybe play an important role in development of the bladder tumors.And ADAM12 may be a promising biomarker of bladder cancer in the clinical behavior.
2.Expression and clinical significance of ADAM-12 and PCNA in bladder carcinoma
Weilong QU ; Laikun TANG ; Feng TIAN ; Zulin WANG ; Li SONG ; Zhongwei YU ; Qing YE ; Ke WANG ; Fengjin WU ; Dexing LUO
Clinical Medicine of China 2010;26(5):524-526
Objective To investigate the expression of adamalysin-12 (ADAM-12) and PCNA in human bladder carcinoma and to investigate their correlation with different grades and stages of bladder cancer.Methods Biopsies of 15 normal bladder and 43 bladder tumors were analyzed.Immunohistochemistry was conducted to detect the expression of ADAM12 and PCNA in the biopsies.Results Postive expression signals of ADAM12 were detected significantly higher in the bladder cancer biopsies than that in the normal ones (P = 0.010).Those with lower histological grade had a higher expression level of ADAM-12 compared to the higher histological grades (P <0.001 ).Positive expression signals of PCNA were detected significantly higher in the bladder cancer biopsies than that in the normal ones (P = 0.026).Those with lower histological grade had a higher expression level of PCNA (P =0.014).There was a positive correlation between the expression of ADAM-12 and PCNA in bladder cancer (r =0.997,P < 0.001 ).Conclusions The overexpression of ADAM-12 and PCNA in the biopsies of bladder tumors shows that protein expression of ADAM-12 and PCNA correlated with tumor stage and grade.Furthermore,ADAM-12 may be a promising biomarker of bladder cancer in the clinical implication.
3.Evaluation of the COVID-19 Policies in OECD Countries
Weilong ZHANG ; Hyungjun KIM ; Rhayun SONG ; Myonghwa PARK ; Keunyeob OH
Health Policy and Management 2022;32(3):293-303
Background:
Coronavirus disease 2019 (COVID-19), which has occurred since the end of 2019, has caused tremendous damage not only in terms of disease and death but also in terms of economy. Accordingly, governments implemented health and quarantine policies to prevent the transmission and spread of COVID-19 and minimize economic effects, and implemented various countermeasures to reduce social and economic damage. However, the damage varies from country to country, and there are differences in the response of each government.
Methods:
Using 2020 data from the Organization for Economic Cooperation and Development countries, the effectiveness of governments’ quarantine and economic policies in response to COVID-19 was calculated, and what factors determine the effectiveness were analyzed. While most of the previous studies analyzed the relationship between the government’s quarantine policy and corona transmission and death, this study is characterized by considering the economic aspect in addition.
Results:
As a result of the analysis, the following results were obtained. First, when economic aspects are not considered, Asian and European countries have similar levels of efficiency, but when economic aspects are taken into account, Asian countries have higher efficiency. Second, population density had a negative effect on the efficiency of each country’s policy, and long-term orientation was found to have an important impact when considering the economic aspect.
Conclusion
We found that the governance index is an important variable influencing the efficiency, which shows that the effectiveness of government policies in response to the coronavirus depends heavily on the trust relationship between the government and the people.
4.Relationship between benign prostatic hyperplasia and chronic prostatitis
Laikun TANG ; Weilong QU ; Feng TIAN ; Zulin WANG ; Li SONG ; Zhongwei YU ; Dexing LUO ; Ke WANG ; Junsheng LI ; Jian SHA ; Boying ZHENG ; Guojun LU
Chinese Journal of Urology 2009;30(2):124-126
Objective To investigate the relationship between benign prostatic hyperplasia (BPH) andchronic prostatitis(CP). Methods Three hundred BPH patients were studied, aged from 51 to 96 (aver-age 72). All patients were divided into 3 groups (Ⅰ°、Ⅱ°and Ⅲ°)according to result of digital rectal examina-tion, which include 85 cases , 139 cases and 76 cases respectively. The incidence of CP among 3 groups were compared and analyzed. Results Two hundreds and thirty-five of the 300 cases with BPH were accompa-nied with CP(77.7%). Among the 233 cases, 53 cases were in Ⅰ degree BPH group (53 / 85, 62.4% ), 113 cases were in Ⅱ degree BPH group (113/139, 81.3%), 67 cases were in Ⅲ degree BPH group (67/76, 88.2%). Conclusions Many BPH patients were accompanied by CP. The prostate size and the inflamma-tion of prostate were positive correlated. The effect of anti-inflammatory treatment in Ⅰ degree and Ⅱ degreeBPH patients was better than Ⅲ degree BPH patients.
5.Different Anesthesia and Sedation Depths of BIS-guided Closed-loop Target-controlled Infusion on Perioperative Th1/Th2 Balance in Elderly Patients Undergoing Laparoscopic Radical Gastrectomy
Huayong JIANG ; Weilong LAO ; Guozhong ZHOU ; Qiliang SONG ; Zongming JIANG ; Weisheng YU ; Zhonghua CHEN
Cancer Research on Prevention and Treatment 2022;49(5):444-447
Objective To investigate the effect of BIS-guided closed-loop target-controlled infusion on perioperative Th1/Th2 balance in elderly patients undergoing laparoscopic radical gastrectomy under different anesthesia and sedation depths. Methods We applied random number table method to divide 73 elderly patients undergoing elective laparoscopic radical gastrectomy into BIS closed-loop target-controlled infusion group with BIS value of 55(group H,
6.Establishment controlled motor cortex impact injury model of rats and detection of motor dysfunction
Weilong SONG ; Guangzhi HAO ; Zhen WANG ; Hai JIN
Chinese Journal of Neuroanatomy 2023;39(6):705-708
Objective:This study was to establish a rat model of controlled motor cortex impact injury(CCI).Methods:SD rat CCI model was prepared by electromagnetic shock method.A neurologic severity score(NSS)was employed to evaluate the status of the rat after injury.The changes of neuron-specific enolase(NSE)in serum were detected by ELISA.The sensomotor function was detected by sticker removal test,and the fine motor function was de-tected by food pellets grasping test.Results:The serum NSE level of rats increased 1 h after CCI trauma,and reached the highest level 6 h after CCI trauma.The sensomotor function and fine motor function of CCI model rats were signifi-cantly impaired.Conclusion:The CCI model of rat motor cortex was successfully established,and the rats showed obvious motor dysfunction.
7.Interpretation of Novel Coronavirus Infection :Expert Consensus on Guidance and Prevention Strategies for Hospi tal Pharmacists and the Pharmacy Workforce
Rongsheng ZHAO ; Yiheng YANG ; Li YANG ; Zijian LI ; Fang LIU ; Zhenyu REN ; Wei LIU ; Zhanmiao YI ; Yingqiu YING ; Xiaoxiao LI ; Yingying YAN ; Huibo LI ; Shujie DONG ; Weilong SHI ; Xiaohan XU ; Pengxiang ZHOU ; Zaiwei SONG ; Siqian ZHENG ; Ying LIU ; Shen ZHOU ; Suodi ZHAI
China Pharmacy 2020;31(4):385-389
OBJECTIVE:To provid e reference for pharmaceutical workers to better understand Novel Coronavirus Infection : Expert Consensus on Guidance and Prevention Strategies for Hospital Pharmacists and the Pharmacy Workforce (hereinafter referred to as “expert consensus ”),and to apply and practice in specific work ,so as to give full play to the role of pharmacists to help fight the epidemic.METHODS :The background of the formulation and revision of the expert consensus were introduced ,and its main contents and viewpoints were interpreted. RESULTS & CONCLUSIONS :The text of expert consensus is divided into 8 parts,mainly including disease diagnosis and treatment [SARS-CoV- 2 infection related background ,clinical manifestations and diagnosis, treatment],hospital pharmacy (prevention and control strategy ,work guidance ),drug and facility support management(key drug/facility/equipment support ,management and use of the drug in special circumstances ),information sources and related resources ,etc.,which comprehensively and detailedly provide information ,guidance and strategies for coronavirus SARS-CoV-2 infection prevention and control to play the role of pharmacists in hospital pharmacy well ,do well in the protection of staff in different pharmaceutical posts ,drug security work in response to epidemic situation ,and develop pharmaceutical care. So far,the understanding of SARS-CoV- 2 in the pharmaceutical industry is relatively limited. Based on the accumulated experience and progress in epidemic prevention and control ,the expert consensus will be updated and improved continuously ,so as to provide guidance and help for hospital pharmaceutical personnel.