Objective To study the influence of insulin therapy at different periods on pregnancy outcomes of patients with gestational diabetes mellitus (GDM).Methods From January 2014 to January 2017,86 patients with GDM in the General Hospital of Taiyuan Iron &Steel(Group)CO.LTD were chosen in the study.All of them were divided into 3 groups based on application periods of insulin:27 patients in groupⅠ(≤28 weeks),31patients in groupⅡ(28－32 weeks),28 patients in group Ⅲ(＞32 weeks).The blood glucose before delivery,duration of insulin application,weight gain and pregnancy outcomes were compared among different groups.Results Before delivery,the HbA1c of group Ⅰ was (5.2 ±0.5)%,which of group Ⅱ was (5.4 ±0.5 )%,which of group Ⅲ was (5.5 ±0.5)%,the difference was not statistically significant among the three groups (F＝0.197,P＞0.05).The duration of insulin application and weight gain during pregnancy demonstrated statistically significant differences among the three groups(F＝5.995,5.334,all P＜0.05).The rate of cesarean section in groupⅠwas 22.22%(6/27),which in group Ⅱ was 32.26%(10/31),which in group Ⅲ was 53.57%(15/28),the incidence rate of macrosomia in group Ⅰwas 3.70%(1/27),which in group Ⅱwas 9.68%(3/31),which in group Ⅲwas 14.29%(4/28),the differences among the three groups were statistically significant (χ2＝9.714,5.294,all P＜0.05 ). Conclusion The early application of insulin can shorten the application duration of insulin,as well inhibit the exces-sive weight gain during pregnancy and improve maternal and neonatal outcomes.

Objective To study the changes and characteristics of TPO -Ab and TG-Ab in type 2 diaetic patients and provide new ideas for the diagnosis of diabetes.Methods From January 2014 to January 2017,160 samples in General Hospital of Taiyuan Iron&Steel (Group) Co.Ltd were selected,80 healthy people and 80 patients with type 2 diabetes,fasting venous 5 mL blood was obtained in the morning ,then electrochemical luminescence method was used to test TPO-Ab and TG-Ab contents.The diabetic patients were divided into four groups :TPO-Ab normal group,TPO-Ab elevation group,TG-Ab normal group,TG-Ab elevation group.The blood glucose,age and gender of the four groups were compared.Results Compared with the control group ,the proportions of increased TPO -Ab and TG-Ab in diabetic patients were 11.25%and 2.5%respectively,the difference was statistically significant (χ2＝4.86,P＜0.05).In type 2 diabetic patients,the blood glucose value of the normal TPO -Ab group was (6.67 ± 1.53)mmol/L,which in the TPO -Ab elevation group was (7.87 ±1.24) mmol/L,the difference was statistically significant (t＝2.94,P＜0.05).The blood glucose of the normal TG -Ab group was (6.75 ±1.34)mmol/L,which in the TG-Ab elevation group was (7.04 ±1.25)mmol/L,the difference was statistically significant (t＝2.82,P＜0.05).TPO-Ab and TG-Ab elevation had no obvious relation with age ,gender.The age of the normal TPO -Ab group was (62.1 ±6.3)years,which in the TPO-Ab elevation group was (63.0 ±4.9)years,there was no statisti- cally significant difference (t＝1.37,P＞0.05).The age of the normal TG -Ab group was (62.8 ±7.1)years,which in the TG-Ab elevation group was (61.6 ±2.7)years,the difference was not statistically significant (t＝1.27,P＞0.05).In male patients,TPO-Ab normal accounted for 84.09%,TPO-Ab rise accounted for 15.91%.In female patients,TPO-Ab normal accounted for 86.11%,TPO-Ab rise accounted for 13.89%,there was no statistically significant difference (χ2＝1.20,P＞0.05).In male patients,TG-Ab normal accounted for 97.73%,TG-Ab rise accounted for 2.27%, in female patients, TG -Ab normal accounted for 97.22%, TG -Ab rise accounted for 2.78%,there was no statistically significant difference (χ2＝0.97,P＞0.05).Conclusion TPO-Ab and TG-Ab in type 2 diabetes patients are higher than healthy people.The increase of TPO -Ab and TG -Ab is positively correlated with blood glucose level.The increase of TPO-Ab and TG-Ab is not correlated with age and gender.