1.A progress in neuroimaging research on the central mechanisms of botulinum toxin in the treatment of focal dystonia
Qinying MU ; Junhao HU ; Fuhao MA ; Hao WANG ; Weikang DOU ; Liyi CHI ; Ming SHI
Chinese Journal of Nervous and Mental Diseases 2024;50(7):440-444
Botulinum toxin(BoNT)is currently the first-line method for treating focal dystonia,which causes muscle paralysis by chemical denervation.Recent neuroimaging studies have found that BoNT treatment could alter neuroplasticity in the brain of patients with focal dystonia.However,the specific central nervous system mechanisms have not been fully elucidated.To this end,here we review the neuroimaging studies on BoNT treatment for dystonia from three aspects:functional magnetic resonance imaging,structural magnetic resonance imaging,and positron emission tomography imaging.It suggests that BoNT may improve the symptoms of dystonia patients by affecting functional connectivity,microstructure,and metabolic levels of the cortex,basal ganglia,thalamus,and cerebellum,etc.Therefore,this review will provide a theoretical reference for further exploring the mechanism and developing potential therapeutic targets of dystonia.
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