Objective To investigate the correlation between the severity of subcortical ischemic lesions and vascular cognitive impairment in encephalorrhagia patients. Methods One hundred and twenty-four encephalorrhagia patients were enrolled into two groups, the normal cognition group (60 cases, without cognitive impairment) and the cognitive impairment group (64 cases, with vascular cognitive impairment). Parameters of the lesion diameters, various lesion locations, white matter lesions severity and NIHSS scale score, modified Bathel index score were compared between these two groups. The correlations between the above indexes and the vascular cognitive impairment degree were analyzed by Logistic regression proceduress. Results Compared to the normal cognition group, the indexes of lesion number of frontal area and basal ganglia, lesion diameters, white-matter severity and NIHSS scale score of cognitive impairment group were higher (P<0.05, respectively), and the modified Bathel index score was lower (P<0.05), but the lesion number in temporal, parieto-occipital and infratentorial area were not changed (P>0.05, respectively) in the cognitive impairment group. Result of Logistic regression analysis showed a positive correlation between the severity of white-matter and the degree of vascular cognitive impairment (OR =4.705, P=0.009). Conclusion The severity of white-matter can effectively assess the degree of vascular cognitive impairment of encephalorrhagia patients.

Objective:To investigate the effects of medroxyprogesterone acetate(MPA) on the proliferation and apoptosis of human colorectal cancer cells.Methods: Human colorectal cancer cell line LS174T was treated with different concentrations of MPA(12.5,25,50 and 100 ?mol/L) for 120 h.The inhibitory effect of MPA was measured with MTT method;the cell cycle,cell apoptosis,and cell surface Fas expression were analyzed with flow cytometry.Results: MPA had significant inhibitory effect on the growth of LS174T human colon cancer cells.Cell growth was found to be arrested in G_(1) phase and cells in S phase and G_(2)/M phase were decreased.The natural apoptosis rate and the apoptosis rates at MPA 12.5 and 25 ?mol/L were 4.8%,15.1%and 25.6%,respectively.Cell surface Fas expression in cancer cells increased after treated with MPA.Conclusion: MPA has significant inhibitory effect on the growth of human colon cancer cells,which may be related to Fas expression upregulation on cancer cell surface and G_(1) phase arrest.

Objective:To explore the pathological mechanism of brain structure in schizophrenia male patients with predominant negative symptoms by Voxel-based Morphometry(VBM) and Wiconsin Card Sorting test(WCST).Methods:Schizophrenia patients were assessed by the Scale for Assessment of Positive Symptoms(SAPS),the Scale for Assessment of Negative Symptoms(SANS).Finally,fifteen male schizophrenia with predominant negative symptoms and fifteen matched healthy controls participated in the study and finished the Wisconsin Card Sorting Test(WCST) and 3D MRI scans.Results:The total trails,the number of response errors and perseverant response errors of WCST in the patient group were significantly higher than those in the control group(P

A success in reconstruction of the hematopoietic function of marrow in a case of malignant lymphoma attained by autologous peripheral blood stem cell transplantation after the ultra-high dose chemoradiotherapy was reported. The platelet count of patient was increased to over 20 ? 109/L at the eighth day after PBSC transplantation and was recovered to over 50?109/L at the tenth day after PBSC transplantation. The white blood cell count was increased to over 0. 5?109/ L at the ninth day after PBSC transplantation. The pelvic CT-graphy showed reduction in size of the tumor. And then the patient was outhospitalized due to remission,having been surviving for more than 6 months with routine follow-up. It was suggested that the autologous peripheral blood stem cell transplantation could be a safe and effective suplement therapy for radical cure of malignant tumor.

Objective To review and analyze the application of retroperitoneal laparoscopy and open surgery in ureteropelvic junction obstruction, sum up clinical expeirence, and improve the skills of retropeirtoneal laparoscopic surgery. Methods Retroperitoneal laparoscopic surgery was carired out in 22 csaes of ureteropelvic junction obstruction(retroperitoneal laparoscopy group). Open surgery was carried out in 21 cases(Open surgery group). The two groups were compared in operation time, blood loss postoperative discharge time and postoperative hospital stay respectively. Results Ureteropelvic junction obstruction group was significantly less than open surgery group in intraoperative bleeding time,postoperative bleeding time and average length of stay. Operation time in ureteropelvic junction obstruction group was slightly longer than that in open surgery group [(32.0 ± 10.0) ml vs (70.0 ± 11.9) ml, (31.0 ±5.7)h vs(52.0 ±6.9)h,(7.0 ± 1.6) d vs(14.0 ± 1.4) d, (113.0 ±7.6) min vs(72.0 ± 6.8) min] (t = 7.06,8. 14,11.37,11.36, all P ＜ 0.05). Conclusions Retroperitoneal laparoscopic technology was in the treatment of ureteropelvic junction obstruction for its direct way, had non interference and pollution to laparoscopic internal organs,less damage,less pain, rapid recovery and short hospitla stay. With on going training and constantly updating technical skills and equipments, retroperitoneal laparoscopic technology will shotren the operation time, and will substitute open surgery.

Objective To analyze the feasibility of theone-cardmode for division-level cadres hospitalized at military hospitals, and to provide reference for application of this mode to cadres under the regimental level who are hospitalized at military hospitals.Methods A 4-month pilot project was carried out among division-level cadres in Lanzhou, Jinan, Nanjing and Chengdu.Data collection and statistical analysis were conducted through the monitoring platform established in the administrative section.Results Division-level cadres outside the system mostly chose division-level hospitals.Patients thended to be hospitalized at nearby or high-quality hospitals mainly due to cardiovascular and cerebrovascular diseases and malignant tumor.Accommodation was not difficult.Conclusion The one-cardmode is feasible at military hospitals for division-level cadres, but the current system of initial diagnosis at basic medical institutions should be maintained.An information sharing platform of electronic medical records should be built to implement inter-hospital linking and sharing of diagnosis and treatment information.A budget subsidy mechanism should be established to normalize hospitalization.

Objective To investigate the clinical value of medial approach in the treatment of posterior tibial plateau fractures.Methods 60 cases with posterior tibial plateau fractures were randomly divided into observation group and control group.The observation group was operated by medial approach,and the control group was operated by medial approach.Results The operation time of the observation group was (138.4 ±18.2)min,which of the con-trol group was (119.2 ±15.8)min,the difference between the two groups was statistically significant(t =4.363,P <0.01).The excellent and good rate of rehabilitation in the observation group was 96.7%,which was significantly higher than 83.3% of the control group (Z =2.237,P <0.05).The fracture healing time of the observation group was (14.5 ±3.3)weeks,which was significantly shorter than (17.9 ±3.6)weeks of the control group (t =3.813, P <0.01).The hospitalization time and incidence rate of complications had no statistically significant differences between the two groups (P >0.05).Conclusion The medial approach in the treatment of the posterior tibial plateau fractures has relatively small injury,reliable fixation,and good rehabilitation.It is one of surgical approaches which worthy of clinical consideration.

ObjectiveTo provide a new method for the predictive diagnosis of PIH through the detection of the PTA blood flowing indexes of the pregnant women. MethodTo adopt the color Doppler ultrasonic wave the conduct the contrast normal pregnant women and PIH women of post-pregnancy 30 cases respectively. Results①The peak value flow rate of blood at diastolic period (short for D), the average blood flow rate (short for MN), the ratio of the peak value blood flow rate (S/D) for PIH group are higher than those for the other two groups respectively (P<0.01); ②There is no statistic difference in the changes of the PTA artery internal diameter between the three groups. ConclusionThe changes in the PTA blood flow indexes of the PIH patients provides a new method for the diagnosis of this disease, which is of some reference value. Such indexes as S, MN and S/D of the PTA are better targets for observation.

Objective: To observe the preventive effect of Bu Shen Jian Pi Capsule on age-related cochlear hair cells apoptosis in C57 BL /6J mice,and research its mechanism of action.Methods: 30 new born C57 BL /6J mice were divided into 2 groups,with 10 animals in control group(CG) and 20 animals in Bu Shen Jian Pi Capsule (experimental group,EG).The animals in CG were fed regularly,while those in EG were fed regularly at the first one months after the birth and then,commonly fed water was substituted by the medical solution of Bu Shen Jian Pi Capsule for these animals in EG.The experimental course lasted for seven months.The cochleas of the two groups of mice were taken out for cochlear surface preparation,then being observed under optical microscope with a comparative analysis on the status of degenerative changes in the hair cells of cochlear between the tow groups.Results: Cochlear hair cells damage of CG animals showed aggravating tendency with the increase of the age,and followed the developmental rules of lesion progression in cochlear hair cells from the basal turn to the apical turn and with the number of outer hair cells loss greater than that of inner hair cells.In contrast,the cochlear damage of animals of EG was relatively milder than that in animals of CG,compared among the animals at the same age between them.Conclusion: This study showed that Bu Shen Jian Pi Capsule could postpone age-related cochlear hair cells apoptosis in C57 BL /6J mice,therefore,it suggested that Bu Shen Jian Pi Capsule might possess the pharmacological action of preventing presbyacusis.We assume the possible protective mechanism of Bu Shen Jian Pi Capsule might be related to increase of cells cAMP,regulation of metabolism of nucleic acid,and protectoin or stabilization of DNA structure.