Objective To investigate the psychopathological characteristics in patients with deviation of nasal septum.Methods Between May 2015 and December 2015,fourty-four patients with deviated nasal septum and 37 patients with vocal cord polyp as control were included in this study.Psychological characteristics were evaluated by a series of questionnaire instruments including symptom checklist-90 (SCL-90),self-rating depression scale (SDS) and self-rating anxiety scale (SAS).Visual analogue scale (VAS) and rhinomanometry through front nostril were used to evaluate nasal symptom.The correlation between psychological characteristics and nasal symptom was evaluated.SPSS 20.0 software was used to analyze the data.Results The SCL-90 score in nasal septal deviation group was 130.4 ± 48.3.The total score and total average score of SCL-90 had no significant difference between nasal septal deviation group and the Chinese standard or control group(t value was 0.469,0.112,1.575,1.564,respectively,all P ＞ 0.05).The scores of somatization,depression and anxiety factors in nasal septal deviation group were higher than control group (t value was 2.380,2.133,1.969,respectively,all P ＜0.05).The proportion of positive patients in these three factors between nasal septal deviation group and control group had significant differences (x2 value was 11.585,9.610,5.429,respectively,all P ＜ 0.05).The scores of SDS and SAS in nasal septal deviation group were 46.0 ± 10.6 and 43.0 ± 10.2,which were higher than that in the Chinese standard and control group (t value was 5.342,6.236,1.476,3.013,respectively,all P ＜ 0.05).There were 9 patients companying with depression or anxiety (20.5 ％,20.5％,respectively) and 5 patients companying with depression and anxiety in nasal septal deviation group (11.4％).There were positive correlation not only between the scores of SDS and the depression factor of SCL-90 but also between the scores of SAS and the anxiety factor of SCL-90 (Z =0.415,P =0.005,Z-0.445,P =0.002,respectively).The scores of SDS and SAS had positive correlation (Z =0.392,P =0.008).The VAS score of nasal obstruction was 6.0 ± 3.2.The rhinomanometry in inspiratory and expiratory phase were (0.202 ± 0.140) kPa · S/cm3 and (0.230 ± 0.161) kPa · S/cm3.Besides the positive correlation between the rhinomanometry in inspiratory phase and SDS (Z =0.332,P =0.045),the psychological scores,including SCL=90 score,depression,anxiety factors score,SAS and SDS,had no correlation with VAS scores and rhinomanometry (r value was-0.030,-0.052,-0.026,0.107,0.185,0.066,0.160,0.203,respectively,all P ＞0.05).Conclusions High prevalence of depression and anxiety is found in patients with deviation of nasal septum.The SCL-90 score is consistent with SDS and SAS.Besides the positive correlation between the rhinomanometry in inspiratory phase and SDS,the psychological scores (SCL-90 score,depression,anxiety factors score,SAS and SDS) have no correlation with VAS score and rhinomanometry.