ObjectiveTo evaluate the safety and efficacy of the refractive effect produced by the implantation of intrastromal corneal ring （ICR）．MethodsEach of the 60 eyes （30 rabbits） received an ICR．The thickness of the ICRs varied from 0.19mm to 0.41mm．Each eye underwent a preoperative and postoperative examinations at the lst，3rd，7th and 14th day；the lst，3rd and 6th month．Slit-lamp biomicroscopy and an ORBSCANTM slit scan corneal tomography／pachymetry system were performed at predetermined intervals throughout the follow-up periods．ResultsThe decrease of corneal curvature was observed after ICR implantation in all of the eyes．There was a direct relationship between the ICR thickness and the degree of corneal flattening achieved．The equation is：D＝1.4353－32.87×thickness．The postoperative refractive effect was stable．Wound healing was uncomplicated and central cornea remained transparent．ConclusionThe ICR implantation is safe and effective and the refractive effect is predictive and stable．