Objective To study the effects of different doses of atorvastatin on serum homocysteine (Hcy) and matrix metallopmteinase-9 (MMP-9) in patients with acute cerebral infarction.Methods Ninety-patients with acute cerebral infarction were randomly divided into two groups,the observation group (n =45 cases) and the control group(n =45 cases).The patients in the observation group were treated by the conventional therapy plus atorvastatin 40mg/d,while the patients in the control group were treated by the conventional therapy plus atorvastatin 20mg/d.Hcy and MMP-9 were detected before and after treatment for one month.Results The total effective rate was 95.6％in the observation group and 86.7％ in the control group.There was significant difference between two groups(x2 =2.1951,P ＜ 0.05).Hcy and MMP-9 were decreased after treatment in both groups and those in the observation group were lower than in the control group (all P ＜ 0.05).Conclusion High-dose atorvastatin can improve patients with acute cerebral infarction through decreasing Hcy and MMP-9.

Objective To investigate the irbesartan combined with metoprolol in the treatment of congestive heart failure and effects on serum Brainnatriuretic peptide.Methods 187 patients with chronic congestive heart failure(CHF),were randomly divided into the observation group 94 cases,93 cases of the control group.The control group was given the strong heart,diuresis therapy.The treatment group on the basis of combined with irbesartan,metoprolol.The content of BNP was detected before and after treatment.Results After treatment,the observation group total efficiency is higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the observation group and the control group of BNP were significantly lower,the difference was statistically significant(P＜0.05).Before and after treatment with BNP reduced value comparison between groups,the observation group than in the control group,the difference was statistically significant(P＜0.05).Conclusion The patients with CHF on the basis of routine treatment,combined with irbesartan and metoprolol,can effectively improve the curative effect,decrease the serum level of BNP,improve heart function.

Objective To observe the clinical effects of levocarnitine combined with sucrose iron injection for treatment of maintenance hemodialysis patients with renal anemia.Methods Forty-four cases of patients with maintenance hemodialysis merged renal anemia were randomly divided into control group (n =22) and treatment group(n=22).All patients were administrated conventional therapy.The sucrose iron injection was administrated with control group at hemodialysis, while treatment group administrated levocamitine after hemodialysis on this basis.The hemoglobin (Hb) and erythrocyte specific volume (Hct) were compared after treatment for 8 weeks,and the clinical effects were evaluated.Results After treatment for 8 weeks, the Hb and Hct(treatment group: (105.69±11.94) g/L, (0.31±0.04);control group: (86.31±11.39) g/L,0.27±0.05) had increased significantly compared with prior treatment(treatment group:(62.65± 12.74) g/L, (0.19±0.04;control group: (63.33 ± 13.23) g/L, 0.20± 0.06) in two groups, and the treatment group increased more significant than control group accompanied with significant statistically difference (t =3.197,2.978;P ＜0.05).Also,the total effective rate of treatment group was 86.4％(19/22) ,which higher than control group(50.0％ (11/22)) accompanied with significant statistically difference (x2 =6.705, P＜0.05).Conclusion The therapy of levocarnitine combined with sucrose iron injection can obviously improve anemia symptoms in patients with maintenance hemodialysis and worthy of popularization and application.

Prescription teaching is a routine task in medical colleges.However it is not a separate course,which can be undertaken by different teaching units or courses,and is not mentioned in training program.So,there are many problems in teaching practice,such as indefiniteness in responsibility,simplification of teaching settings,maladjustment to teaching and training objective and so on.Thus administrative department and major leaders should deepen the understanding of prescription teaching,take full account of its position in planning the training program,and make it more scientific to meet the needs of professional training.

The authors have determined the effects of 261-B_2-3 and C_(12)b_3-2, extracts two strains of Alternaria alternata, on the nucleolus organizer regions (NORs) activity and the progression of cell proliferating cycle of human peripheral lymphocytes. The methods used in the experiment were selective silver staining of human NORs and cytophotometry. The result showed that the number of chromosomes bearing Ag-NORs was meaningly decreased when the cells were treated with different concentrations of 261-B_2-3 and C_(12)-b_3-2 extracts. The difference was quite significant when the data were compared with those of the control (P

The forepassed socialized medicine system for urban workers has many ethical faults. The institutional reform on the social medical insurance for urban workers will readjust the relationships between government, hospitals, employers and patients. It means much to ethics, and impulses the basic health service towards self-determination, duty and justice. But it has some problems about the responsibility of government,the sanction of hospitals and the burden of patients. At last,the paper offers some suggestions for improvement.

0.05).CONCLUSION:Group C is the preferable one among the three groups.

OBJECTIVE:To evaluate the economic effects of artesunate(ART)versus Quinine MAX(QUI)in treating malaria.METHODS:A total of 64 patients with malaria were randomly assigned to receive ART or QUI for 7 days,with cost-minimization analysis conducted on the 2 therapeutic scheme.RESULTS:The average cost for ART vs.QUI scheme was 341 yuan vs.485 yuan,showing significant differences between the 2 schemes(P0.05).CONCLUSION:The artesunate is preferable compared with QUI and could be popularized in poverty-striken area such as Africa.

Objective To study the correlation between the polymorphism of Interferon γ( IFN-γ) ( + 874 T/A) gene and susceptibility to the development of lung cancer. Methods The polymorphism of IFN-7 gene( + 874 T/A) in 42 patients with lung cancer and 60 healthy control subjects was detected by using sequence-specific primers polymerase chain reaction( PCR-SSP) and their susceptibility to development of lung cancer was analyzed. Results The genotypic frequencies of AA of IFN -γ Gene( + 874 T/A) in the control group and the patient group were 0. 533, 0.786 .respectively and the genotypic frequency of AA in control group was significantly lower than that in the patient group ( P < 0. 01) , in contrast with which the genotypic frequencies of AT and TT in the control group were significantly higher than those in the patient group (P < 0. 01 ,P < 0.05). The A allele frequency of IFN-γ gene in the patient group was statistically higher compared with that in the control group(0. 869 vs. 0.7 ,P <0.01 ) ,in which the relative riskrate(RR) was 2.84,95%CI 1. 31 ~6.15 ,P<0. 01. Conclusion The polymorphism of IFN-γ gene ( +874 T/ A) could be associated with susceptibility to the development of lung cancer,so it could be considered one of the genetic markers to be used to early identify individuals at high risk of lung cancer.

OBJECTIVE:To evaluate the physiochemical characteristics of resin restorative material and its clinical application in repairing dental caries.METHODS:Related papers published between January 1995 and January 2010 were searched using key words of "dental caries,resin,restoration,dental pulp,wear resistance and hardness" both in English and Chinese from databases of Medline and Chinese Journal Full-text Database.RESULTS:As a kind of cosmetology repair material,the color of resin restorative material is similar to the natural teeth,and exhibits strong bonding force to enamel.But,the mechanical features of which is smaller than dental amalgam.The composite resin commonly comprised crystalline quartz and fumed silica,which had advantages of insufficient mechanical strength,poor wear resistance and great polymerization shrinkage.Recently,the research of resin gained breakthrough and newly typed composite resin was developed.Though the mechanical strength has been notably improved,it is still far from the requirement.The polymer-metal nano-resins,such as tantalum oxide nanoparticles and zirconia-based resin,can not only enhance the strength,decrease polymerization shrinkage,but also exhibit good appearance and surface properties,therefore are themost promising materials.CONCLUSION:At present,plenty of resin restorative materials were used in caries fillings with own advantages and disadvantages.Novel composite resin would be widely used in future due to its unique superiority.