This article discusses the important effect of language techniques in the pharmacology teaching,according to the peculiarity of this speciality and the experience of author,and the concrete language techniques to activate the class to attract the students' attention and to improve teaching effect from the aspects of the basic request of language expression in class,the scientificity and the logicality and the enlighten and techniques of teaching language in pharmacology class.It also explains the importance of language techniques in the pharmacology teaching from many aspects.

[Objective] To mensurate and compare with the mensuration of alkaloid and saponin in the flower,pedicel and bulb of fritillariae thuubergii,make full use of all parts of fritillariae thuubergi.i[Method]To mensurate the mensuration of alkaloid and saponin in the three parts of fritillariae with the twophase titration method and gravimetric method.[Result]The mensuration of alkaloid in the flowers of fritillariae thuubergii is 0.182%,while it is 0.047% and 0.341% in the pedicel and bulb separately,and the mensuration of saponin in the flowers of fritillariae thuubergii is 5.112%,while it is 8.840% and 1.724% in the pedicel and bulb separately.[Conclution] The difference of major component in the fritillariae thuubergii offers the foundation to make full use of the flowers,pedicel and bulb.

Objective To summarize the main nursing point and experience of allogeneic small bowel transplantation.Methods One case underwent allogeneic small bowel transplantation in our hospital on the first of December 2010,the nursing measures were summarized.Results The patient passed the operation well-off,and survived the infection phase and repulsion phase in the transplantation ward.Conclusions Valid preoperative evaluation,taking active measures to prevent intraoperative hypothermia and infection,using self-made vacuum pads to prevent pressure sores during operation,are the guarantees for successful operation.

Misoprostol, a prostaglandin E1 analogue, have variety clinical applications. In early 80's, misoprostol is currently licensed primarily to prevent non-steroidal anti-inflammatory drug-associated gastric and duodenal ulcers. Further work shows the drugs have protection to hepatic and renal and prevention of inflammatory and allergic disorders. When combined with mifepristone,complete abortion rate is 95%. On the other hand, misoprostol is also an effective agent for cervical ripening and labor induction. It have no serious side effect, as a result, misoprostol is a drug of high effect and low toxicity, deserving popularization, but man and pregnant woman must prudent.

γ-Secretase is aⅠtransmembrane protease associated with Alzheimer disease(AD), and including four subunits:presenilin,presenilin enhancer-2,anterior-pharynx-defective1 and nicastrin. In recent studies,the ultra-high-resolution cryo-electron microscope has been used for the first time, revealing the humanγ-secretase″horseshoe″,the three-dimensional structure and the arrangement of the subunits. This technique has shed light on the regulation of the enzyme pathway and mechanism. In addition,the γ-secretase modulators,including non-steroidal anti-inflammatory drugs,have been shown in vitro to inhibit γ-secretase activity and selectively reduce the level of Aβ42 against AD. They have provided an effective approach,with broad prospects for development. Studies in this area have become a hot topic in recent years. Here we summarized the γ-secretase subunits regulatory pathways, humanγ-secretase fine three-dimensional structure andγ-secretase modulators .

Objective To explore and compare the effect of sevoflurane and disoprofol to inflammatory factors in patients received abdominal surgeries.Methods Patients with sevoflurane and disoprofol respectively were anaesthetized and detected IL-6,IL-8,IL-10 and TNF-α in their serum at T1 (when anesthesia induction),T2 (after anesthesia induction),T3 (30min after beginning of operations) and T4 (after operations).Results Compared with T1,the serum level of IL-6,IL-8,IL-10 and TNF-α increased significantly in all patients(all P ＜ 0.05) ; Compared with disoprofol group,the serum level of IL-6,IL-8 and TNF-α increased significantly (all P ＜ 0.05) ; Compared with sevoflurane group,the serum level of IL-10 increased significantly(all P ＜ 0.05).Conclusion Intravenous anesthesia with disoprofol in patients receiving abdominal operations is proper for maintenance of inflammatory balance.

Objective To probe the changes of nitric oxide (NO) content and caspase-3 mRNA expression in hippocampus and the correlation between NO and caspase-3 mRNA expression post-status epilepticus (SE). Methods The models of SE were induced by pilocarpine. The nitric oxide content was detected by chromatometry and caspase-3 mRNA expression was observed by reverse transcription polymerase chain reaction (RT-PCR) method. Results The level of NO increased rapidly at 6~72 h post-SE,and was still significantly higher than that of the controls (all (P)0.05).Conclusions The peak expression of nitric oxide is earlier than caspase-3 mRNA post-SE, although they have the similar diversity tendency. Nitric oxide pathway is definitely involved in the seizure initiation and correlated with caspase-3 activation.

OBJECTIVE To investigate distribution status and drug-resistance of pathogens from infected urinary tract and offer scientific evidence for reasonably clinical usage of antibiotics.METHODS A total of 336 strains of pathogenic bacteria isolated from urinary tract infection from 2003 to 2007 were identified,and antibiotic susceptibility test was performed by K-B methods.RESULTS The total isolating rate of Gram-negative bacilli was 78.3%.And that of Gram-positive cocci was 16.4%.Escherichia coli accounted for 64.9%,ranking the first.Except for 100% sensitive to vancomycin in Gram-positive cocci and 100% sensitive to imipenem in Gram-negative bacilli,all pathogens were resistant to the other antibiotics in different degrees.The detection rate of extensive-spectrum beta-lactamases(ESBLs) producers in E.coli and Klebsiella pneumoniae were 25.7% and 28.0%,respectively.CONCLUSIONS The drug-resistance of pathogenic bacteria from infected urinary tract emergs in Yinshan County.We should adopt effective measurement to prevent and control it.

Objective To investigate the protective effect of exogenous oxygen and superoxide dismutase (SOD) on acute spinal cord injury. Methods A rabbit model of L2 spinal cord injury was produced by Allen's method, and then the rabbits were randomly divided into experimental group and control group. In the experimental group, the rabbits received exogenous oxygen, SOD or both 30 min after injury. 12h after injury, the amount of MDA and SOD of spinal tissues were determined, and pathological changes of spinal cord were observed at the fourth weeks after injury. Results Combinant administration of exogenous oxygen and SOD could inhibit MDA production and increase SOD activities, effect of which was stronger that single administration (P

Modern management is in essence management of people and the idea and strategy of humanistic management infiltrate into various management activities of a hospital. Our hospital has attempted to enhance the ideological quality and vocational level of the nursing staff by the theory of humanistic management. As a result of such measures as stimulating the nursing staff's thirst for knowledge, enlarging the scope of rewards, increasing the work pressure of young nurses in a proper way, providing room for the free development of head nurses, implementing dynamic management, and adopting democratic management with a high degree of openness, the ideological quality of the nurses has been greatly enhanced. At the same time, measures have been taken to ensure from 3 links that their vocational level keeps improving as well.