Objective To investigate the clinical characteristics of non-motor symptoms ( NMS) in early stage newly diagnosed Parkinson 's disease ( PD) patients in different age group and different subtypes .Methods Total 96 newly diagnosed PD patients without taking any drugs and 102 normal controls were collected in outpatient visits , and their clinic information and related scales were evaluated and compared .Results Ninety-one(93.83%) PD patients had at least one NMS, common symptoms were, in order, recent memory (70.83%,68 cases)、constipation (48.96%,47 cases)、attention dysfunction (47.92%,46 cases), and they were significantly higher than PD group (all P<0.01).The incidence of anxiety and panic in patients≤60 years old was significantly higher than that in patients>60 years old (P<0.01).The incidence of urgency in rigidity type was significantly higher than in tremor type(P<0.01).Conclusions NMS in patients with newly diagnosed PD are complex and diverse .The performance in different age groups and different clinical subtypes are also different .

Objective To study the prevalence and progression of non-motor symptoms (NMS) during 2 years follow-up in idiopathic PD patients,and to investigate the relationship of NMS with quality of life and motor symptoms.Methods A total of 82 idiopathic PD patients were involved in the survey.Unified Parkinson's Disease Rating Scale (UPDRS) and Non-Motor Symptoms Questionnaire for Parkinson's disease (NMSQuest) and Mini Mental State Examination (MMSE) were used to assess non-motor symptoms.Results The NMS total scores were higher at the end of follow-up than at baseline [(11.97±5.54) vs.(9.45±5.13),r=0.620,P=0.007].The scores of 6 symptoms including daytime salivation,constipation,photism or auditory hallucination,depression,sleep walking or somniloquy,diplopia,and 4 syndromes including digestive system,hallucination and delusion,cardiovascular system and other system were significantly increased.The symptoms of hallucination and delusion,and the decrease of recent memory at baseline had significant correlations with the decline of quality of life and the aggravation of motor symptoms (r=0.625,0.578,P=0.016,0.035).Conclusions NMS present in the whole course of PD and show rapid changes.NMS have correlations with the decline of quality of life and the aggravation of motor symptoms.

Objective To investigate the clinical features and outcome of retroperitoneal fibrosis (RPF).Methods Thirty-three cases of RPF treated in the Department of Rheumatology and Immunology were analyzed retrospectively,including the clinical characteristics and laboratory data.Results RPF occurred predominantly in elderly men with untypical clinical manifestations such as back pain,abdominal pain and lower limb edema.In laboratory tests,the inflammatory parameters such as erythrocyte sedimentation rate and C-reactive protein increased significantly,and renal function failure was frequent finding in patients with urethral obstruction.All patients had retroperitoneal soft tissue image or urethral obstruction on computed tomography or magnetic resonance imaging,four of which had histological diagnosis of idiopathic RPF.Twenty-three patients received surgical interventions.Eighteen patients received medical treatment alone including corticosteroids,immunosuppressants,and tamoxifen.Nine patients received corticosteroids after surgical intervention.Surgery and medical treatments are effective for idiopathic RPF.Conclusion Image examination is valuable in diagnosis and differential diagnosis of PRF.Pathological diagnosis is the golden standard.Long-term low dose corticosteroids and immunosuppressants may prevent relapse of idiopathic RPF.

The stem cell technology has a broad prospect for human health,but it would also give rise to ethical issues which cannot be ignored.To deal with these issues,we ought to adopt new approaches.The traditional vertical government approaches ought to be replaced with horizontal governance.Based on the new governance approaches,this paper proposes four suggestions for relieving the ethical impacts imposed by stem cell technology.These suggestions will be helpful for developing healthy stem cell technology.

BACKGROUND: People, with various live patterns, have different impacts when walking, while the impact type always takes effects on shock attenuation of people. Foreign researches had shown shock attenuation during walking had been linked to many kinds of injuries.OBJECTIVE: This study aimed to examine whether dancers with different dancing patterns would show different impact shock attenuation when walking.DESIGN: A controlled observation.SETTING: Sports College, Guangxi Normal University; College of Human Movement Science, Beijing Sports University.PARTICIPANTS: Fourteen old social dancing exercisers who had 3 years of dancing exercises and exercised 1.0-2.0 hours per day were selected from family members' area of Beijing Sports University and recruited for this study. Seven subjects dancing with smooth rises and falls were selected into one group (namely group A) by a professional social dance teacher and another seven retires dancing with abrupt rises and falls were selected into another group (namely group B). The age, body height and body mass of subjects between two groups could be comparable. METHODS: The BK4393 uni-gain miniature accelerometers (Denmark) were attached to the skin of 3 cm below the tubercle of tibia and median line of frontal bone in subjects to test their the impact acceleration during normal speed. At the same time, retires' gaits were filmed by a normal speed camera to get the kinematic variables. All variables related to shock attenuation were compared by statistical means, and the difference of shock attenuation between two groups were analyzed.MAIN OUTCOME MEASURES: Related extremity gait kinematic parameters, peak acceleration of tibia and head, and impact shock attenuation during normal walkingRESULTS: Fourteen subjects participated in the finial analysis. Group B showed significant higher values of the maximum knee angle, maximum ankle angle and total angle change of ankle joint statistically than group A (P ＜ 0.05). There were no significant differences in impact acceleration of tibia stance phase between two groups (P ＞ 0.05), impact acceleration of head in the group A was lower than that in the group B (P ＜ 0.05), and shock attenuation between tibia and head was better in the group A than in the group B (P =0.007). CONCLUSION: Dancing with smooth rises and falls is beneficial to enhancing shock attenuation ability and improving ankle dorsiflexion control and the whole coordinated ability in social dancing exercises.

Objective To study the effects of the effective composition of Angelica sinensis injection on the functional state of platelet in patients with ulcerative colitis (UC),and its significance of therapy.Methods In 64 patients with UC and 30 healthy people, a-granule membrane protein (GMP-140), thromboxane B 2(TXB 2), 6-keto-PGF 1a were detected by means of ELISA.Platelet adhesion rate was detected by the platelet adhesion meter, von willebrand faetor related antigen (vWF:Ag) was also detected by the means of monoclonal -ELISA.Results The indexes of platelet activation and vWF:Ag in patients with UC were significanrly higher than those in the control group (P

HIV-1 fusion inhibitors are a new class of anti-HIV compounds, which block the entry of HIV into target cells through preventing the fusion between viral and cell plasma membrane and thus interrupt the initial steps of viral replication. T-20 (enfuvirtide), which has been clinically approved as the first fusion inhibitor of HIV-1 by U.S. FDA in 2003, can suppress replication of HIV variants with multi-drug resistance to reverse transcriptase and protease inhibitors. Peptides and small molecules display potent anti-HIV fusion activities by targeting gp41 thus inhibit its fusogenic function. In recent years, with the development of studies on the molecular mechanism of HIV membrane fusion process and the function of gp41, many new fusion inhibitors are found and some have been in advanced clinical trials. This review discusses recent progress in the development of HIV-1 fusion inhibitors targeting the gp41.

Objective To study the chemical composition of traditional Chinese medicine Xiasangju compound extract.MethodsThe ethanol extract of different organic solvent extraction,silica gel column chromatography,chromatography separation and purification technology for the separation of compounds,the structures were elucidated by chemical and spectral data.ResultsSix fiavonoid components were isolated from the ethyl acetate extract,respectively, kaempferol( Ⅰ ),quercetin( Ⅱ ),luteolin( Ⅲ ),quercetin-3-O-β-D-glucoside (Ⅳ),luteolin-7-O-β-D-glucoside ( Ⅴ ) and rutin (Ⅵ).ConclusionThe obtained compounds were isolated from compound Xiasangju for the first time.

BACKGROUND:Lumbar fusion surgery as an important and effective means of treating degenerative diseases is widely used in clinical application for almost a century. However, long-term clinical evidence showed that lumbar fusion also brought some problems, such as the loss of waist flexibility, complications of donor site, fusion segment motion loss and accelerating the adjacent segment degeneration. In recent years, the theory of spinal dynamic stabilization had spread widely, and a variety of non-fusion surgery is becoming more broadly used in treatment of lumbar degenerative disease. OBJECTIVE:To review the application of non-fusion surgery in the treatment of lumbar degenerative diseases and explain application perspectives and experiences. METHODS:Databases including PubMed and CNKI were retrieved to col ect clinical application and views about non-fusion internal fixation in the treatment of lumbar degenerative diseases from 2007 to 2016. The key words were“lumbar, non-fusion, bone fusion, dynamic stabilization, adjacent segment degeneration”. RESULTS AND CONCLUSION:Thirty papers were included in the final analysis after screening by two independent researchers. We summarized the lumbar non-fusion technology, including artificial nucleus replacement, total disc replacement and posterior lumbar dynamic stabilization device. The philosophy of these new technologies is to provide stability and physiological activity, reducing the abnormal stress that leads to adjacent segment degeneration. These methods can be applied to the step of treatment of lumbar degenerative diseases and to reduce the fusion of diseased segments. Simultaneously, it is needed to strictly grasp the indications for surgery, to identify the cause of the pain caused by low back pain and lumbar spine instability, and to select the most suitable non-fusion device for individual treatment.

OBJECTIVE:To explore the prognosis effect of Shengmai injection to the rt-PA thrombolysis on broadened thera-peutic window patients of mild-to-moderate cerebral infarction under the guidance of computer tomography(CT). METHODS:168 patients with mild-to-moderate cerebral infarction were randomly divided into control group (84 cases) and observation group (84 cases). Control group received rt-PA(0.9 mg/kg),and 10% of the total rt-PA was mixed and injected into patients within 1 min, the rest 90% adding into 250 ml 0.9% Sodium chloride injection (no less than 1 h),CT was performed after 24 h thrombolytic therapy,and the patients with no intracerebral hemorrhage in re-examination received 300 mg/d aspirin for 10 d,then 100 mg/d for 90 d,and appropriate statins,calcium antagonists,β-blockers and nitrates;observation group additionally received 40 ml Sheng-mai injection,adding into 250 ml 5% Glucose injection,intravenous infusion,once a day,for 28 d. National Institutes of Health Stroke Scale (NIHSS) score,Rankin score,daily living-Barthel Index (Barthel) score,rate of symptomatic intracranial hemor-rhage,rate of secondary hemorrhage,hospitalization time,3-month postoperative mortality and incidence of adverse reactions in 2 groups were observed. RESULTS:Before treatment,there were no significant differences in the NIHSS score,Rankin score and Barthel score(P>0.05). The NIHSS score in 2 groups after 6 h,24 h and 7 d were significantly lower than before,and observa-tion group was lower than control group after 24 h and 7 d;Rankin score after 3 months was significantly lower than before,and observation group was lower than control group;Barthel score after 3 months was significantly higher than before,and observation group was higher than control group,The differences were statistically significant (P<0.05). The hospitalization time in observa-tion group was significantly shorter than in control group,and 3-month postoperative mortality was significantly lower than control group,the differences were statistically significant(P<0.05). There were no obvious adverse reactions during treatment. CONCLU-SIONS:Based on conventional treatment,Shengmai injection has improvement in the rt-PA intravenous thrombolysis on broadened therapeutic window patients of mild-to-moderate cerebral infarction under the guidance of CT,it can reduce NIHSS score and Rankin score,increase Barthel score,shorten hospitalization time and reduce the 3-month postoperative mortality,with good safety.