Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the intestine mediated by abnormal immunological mechanism caused by multiple etiological factors.The main treatment at present is anti-inflammation and immunosuppression,but with severe side effects and poor efficacy.Vitamin D3 has immunoregulatory,anti-inflammatory,and antineoplastic functions.Vitamin D,as a novel immunoregulator,may provide a new treatment option for patients with IBD.This article will review the research progress on the following four aspects:the relationship of vitamin D with innate immunity,adaptive immunity,and pathogenesis of IBD,and vitamin D supplement in IBD patients.

The stem cell technology has a broad prospect for human health,but it would also give rise to ethical issues which cannot be ignored.To deal with these issues,we ought to adopt new approaches.The traditional vertical government approaches ought to be replaced with horizontal governance.Based on the new governance approaches,this paper proposes four suggestions for relieving the ethical impacts imposed by stem cell technology.These suggestions will be helpful for developing healthy stem cell technology.

Objective To compare the medium-term clinical effects of oblique T-shaped volar locking compression plate (LCP) and external fixation (EF) treating type C distal radial fractures.Methods Data of 60 patients with type C distal radial fractures who underwent surgery in our hospital from May 2010 to November 2012 were retrospectively analyzed.36 patients received open reduction with LCP fixation (LCP group),among which there were 21 males and 15 females,and there were 20 left wrists and 16 right wrists with an average age of 45.94±16.29 years old (range,17-80 years old).24 patients received close reduction and external fixation (EF group),among which there were 16 males and 8 females,and there were 15 left wrists and 9 right wrists with an average age of 43.63±14.55 years old (range,16-79 years old).The clinical results of wrist joint were assessed by range of wrist activity,VAS,Gartland-Werley wrist score,postoperative radial tilt angle,radial inclination angle and radial height.Results All the 60 patients were followed up successfully.The LCP group was followed up for 24 to 55 (42.03 ± 8.62) months.The EF group was followed up for 24 to 54 (37.24±9.77) months.In the LCP group,the average VAS score was 1.28±0.78,Gartland-Werley score 2.28±0.78,wrist flexion angle 50.89°±5.53° and wrist dorsiflexion angle 50.69°±5.38°.In the EF group,the average VAS score was 1.38±0.71,Gartland-Werley score 2.92± 1.69,wrist flexion angle 50.96°±5.01° and wrist dorsiflexion angle 51.08°± 5.73°.No statistically differences were found in wrist joint function between two groups.In LCP group,radiological evaluation 2 years after operation showed that the average radial tilt angle was 10.69°±2.29,radial inclination angle 22.53°± 1.95° and radial height 10.63±1.14 mm.In the EF group,radial tilt angle was 6.63°±2.76°,radial inclination angle 16.96°±4.41° and radial height 9.06±0.98 mm.Significant differences were found in radial tilt angle,radial inclination angle and radial height.No statistically differences were found in postoperative complication rates.Conclusion Locking compression plate (LCP) fixation and external fixation (EF) can obtain similar satisfactory medium-term clinical outcome in treating type C distal radial fractures.Comparison with EF,LCP can achieve anatomic reduction under direct vision,and its radiological assessments including radial tilt angle,radial inclination angle and radial height were significantly better than external fixation.

Objective To investigate the related risk factors of prognosis in patients with systemic lupus erythematosus (SLE) complicated with lung infection.Methods The clinical data of 84 cases with SLE complicated with lung infection were analyzed retrospectively.Multivariate Logistic regressive analysis was made with death and survival as the independent variable.Results There were 23 out of 84 patients dead,and fatality rate was 27.38％.Multivariate Logistic regressive analysis showed that the urine volume,immune globulin treatment,cyclophosphamide pulse therapy,plasma albumin and SLE disease activity (SLEDAI) score were the risk factors that influenced the prognosis (OR =0.53,0.72,4.29,0.94,1.58,respectively,P＜0.0l or ＜0.05).Conclusions The prognosis of patients with SLE complicated with lung infection is the result of the joint action of many factors.The higher SLEDAI score and cyclophosphamide pulse therapy are the independent risk factors of the prognosis.The increase of plasma albumin level and urine production and immune globulin treatment are helpful to decrease the fatality rate.

Objective To compare the morphology and histology about the chronic atrophic gastritis (CAG) narrow-band imaging (NBI),in order to improve the rate of final diagnosis.Methods The clinical data of 100 CAG patients who diagnosed by NBI from September 2011 to December 2012 were analyzed retrospectively.The morphological diagnosis by NBI and histodiagnosis by endoscopy were compared.Results In 100 patients,94 patients were diagnosed by histodiagnosis among whom 28 patients were with mild dysplasia,8 patients were with moderate dysplasia,7 patients were with severe dysplasia.In the NBI mode,gastric pits were divided into 6 kinds of types,dysplasia mainly expressed for Ⅳ and Ⅴ 1 type.In 7 severe dysplasia patients,2 patients of microvascular morphology were regular,the others were anomalism,and found neovascularization.Conclusions Endoscopic NBI technology has the advantage of simple operation,and can clearly observe the gastric pit and microvascular morphology after amplification.It can help to improve the accuracy rate of CAG and dysplasia targeted biopsy.

Objective To detect the expression of selenium binding protein 1 ( SBP1 ) in gastric cancer cell line SGC7901, BGC823, normal gastric epithelial cell line GES-1, gastric cancer tissues and normal gastric tissues, explore the relationship between SBP1 and pathologic features, and discuss the feasibility of SBP1 as an diagnostic marker of gastric cancer. Methods The clinical data of 135 patients with gastric cancer who were admitted to Zhongnan Hospital of Wuhan University from 2006 to 2007 were retrospectively analyzed. The expression of SBP1 in the gastric cancer tissues and 16 cases of normal gastric tissues were detected by immunohistochemistry. The mRNA and protein expressions of SBP1 of SGC7901, BGC823 and GES-1 were determined by Western blot and RT-PCR. All data were analyzed by using chi-square test and one-way analysis of variance.Results The mRNA expressions of SBP1 in BGC823 and SGC7091 were 0. 120 ± 0. 020 and 0. 133 ± 0. 015,respectively, which were significantly lower than 0. 907 ± 0. 015 in GES-1 ( F = 2106. 462, P ＜ 0.05 ). The protein expression of SBP1 in BGC823 and SGC7901 were 0.253 ±0.015 and 0.273 ±0.015 ,respectively, which were significantly lower than 0.877 ±0.025 in GES-1 ( F = 1026. 758, P ＜0.05 ). A strong positive reaction of SBP1 was observed in 3 cases of gastric cancer tissues and 16 cases of normal gastric tissues. The decrease of the protein expression of SBP1 was correlated with clinical stages of the patients ( x2 = 12. 629, P ＜ 0.05 ), rather than the sexes, ages, tumor histological types, tumor differentiation, infiltration depths and lymph node metastasis (x2 =2. 142, 0.860, 1.838, 5.001,4.858, 1.994, P＞0. 05). Conclusions The decrease of SBP1 expression could be used as a marker in diagnosing gastric cancer. Down-regulation of SBP1 expression may play an important role in the genesis and prognosis of gastric cancer.

Objective To explore the clinical significance of cytokeratin(AE1/AE3) immunohistochemical staining in detecting the lymph node micrometastasis of gastric cancer.Methods Immunohistochemical S-P method was used to examine AE1/AE3 in 118 lymph nodes in 64 cases of primary gastric cancer.Results Among 118 lymph nodes,micrometastasis was found in 13 lymph nodes of 8 patients with primary gastric cancer by AE1/AE3 staining.The positive rate of micrometastasis was 12.5% and the positive rate of lymph nodes was 11.02%.The incidence of micrometastasis was related with the depth of invasion,and in the cancer with deep invasion,the positive rate of micrometastasis was higher than that in the cancer with superficial invasion(P

Objective: To discuss the effect of volatile organic compounds to the potential of embryonic development. From the angle of the laminar flow process, we found ways to control VOCs to ensure that the potential of embryonic development. Methods:To collect the air from the outdoor, laboratory hundred and thousand grade level central corridor three VOCs for testing;we used raw, medium effect filter to replace the original filter and got different results. Results:The indoor VOCs were higher than outdoor;Changes in concentrations of VOCs can affect embryonic development potential. The effect of replaced filter is bigger. After a period of time in a laminar flow system, it gradually getting better and finally change more than before. Conclusion:The embryo laboratory has volatile organic compounds VOCs. VOCs have larger influence on embryonic development potential and can be effectively controlled.

Objective To monitor pulse oxygen saturation(SpO_2)continuously in patients with chronic obstructive pulmonary disease (COPD) so as to study its clinical implication.Methods SpO_2, thoracic and abdominal respiratory activity was continually recorded during meal time by PSG in 19 patients with COPD. Body mass index and lung function were measured respectively. Results SpO_2 was lower after meal(P

Objective To study PFSDQ-M in evaluating meal-induced hypoxemia in patients with chronic obstructive pulmonary disease.Methods PFSDQ-M scores were collected from 63 COPD patients;49 of them were performed spirometry and meal-related SpO2 monitoring.On the basis of different lung function parameters,data analysis was used to assess the relationship between PFSDQ-M and meal-induced hypoxemia.Results The SpO2 fluctuation during eating period was of significant difference in COPD patients with 3 respective levels of pulmonary function parameters (P