Statins,the inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)reductase,are mostly prescribed for the treatment of hyperlipidemia and prevention of cardiovascular events. Several studies have suggested that statins can reduce the risk of colorectal cancer,however,there is still a debate on its chemopreventive effect. This article summarized the local and overseas studies focusing on this issue,and made a brief overview on the effect of statins in prevention of colorectal cancer and adenoma and its potential mechanisms.

Objective To design and apply the nursing quality management system of our hospital in order to strengthen nursing informationization construction, and improve management efficiency of nursing quality. Methods Based on the original design of nursing management system, the quality management system which take nursing as the main part was researched and developed by us and applied to the clinical. Our nursing management department combined PDCA cycle with our nursing quality management, and developed nursing unit quality evaluation criteria, each ward were checked by evaluating group of nursing quality management, the analysis and corrective measures should be asked to put forward. Results From July to December in 2016, nursing accidents, pressure ulcer, tumbling, pipe slippage, medication, errors and all adverse events incidence compared with 2015 year dropped 60.00％(0.03/0.05), 43.33％ (0.13/0.30), 50.00％ (0.04/0.08), 40.00％ (0.04/0.10), 33.33％ (0.01/0.03),43.85％(0.25/0.57), and all adverse events in 2016 compared to the period of 2015 had statistically difference (χ2=7.266, P<0.05), and the problem rectification rate was significantly higher than before(χ2=-3.212--2.637,P<0.05). Conclusion The construction and application of nursing quality management system realized the informationization and resource sharing of nursing quality management, it will help the quality of management to upgrade continuously and improve the efficiency of nursing quality management.

The modification of proteins with ubiquitination is closely related to the occurrence and development of chronic liver disease and hepatocellular carcinoma. The tripartite motif (TRIM) family of proteins is one of the E3 ubiquitin ligase subfamily, which participates in various biological processes such as intracellular signal transduction, apoptosis, autophagy, and immunity by regulating the ubiquitination of target proteins. A growing body of research shows that the TRIM family of proteins plays an important role in chronic liver disease. This article systematically reviews the role and molecular mechanism of TRIM protein in the process of chronic liver disease, with the aim of exploring its potential application in the clinical diagnosis and treatment.