Effect of 10% lard diet on lipid compositions and the activity of cyto-chrome oxidase of cardiac mitochondria from guinea pigs was observed. The results showed that after feeding the diet for 50 days, the activity of cyto-chrome oxidase of the experimental animals tended to be lowered; the total cholesterol content was increased; in contrast, the total phospholipid content was decreased. As a result, the molar ratio of total cholesterol to total phospholipid was significantly raised (P

Aim To study effects of vigabatrin on absence-like seizures and tonic convulsions in spontaneously epileptic rats (SERs). Method Electrcorticogram and depth electroencephalographic activity in hip- pocampus of SERs were recorded with implanted electrodes after administration of vigabatrin. Results The number of absence-like seizures was significantly reduced from 100% to (54?5)%, (41?9)% and (34?4)% (P

0.05). But typeⅢsodium channel expressed higher than that in control groups in hippocampus, restriction mapping analysis showed thatⅢN increased significantly (P