Objective To investigate the diagnostic value of diameter ratio of pulmonary artery or ascending aorta in chronic obstructive pulmonary disease (COPD)patients with pulmonary hypertension.Methods 60 COPD patients with secondary pulmonary hypertension were selected as the study group,then 60 cases of normal pulmonary artery pressure COPD patients were selected as the control group.By comparing the pulmonary artery and aorta diame-ter ratio rose of the two groups to judge the value slow lung disease in patients with pulmonary hypertension of the resistive prompt action.Results The MAPD and MAD ratio of the study group was significantly higher than in the control group[(1.04 ±0.01)vs (0.83 ±0.02),t =12.572,P =0.000],and pulmonary artery high pressure ratio was positively correlated with the relative coefficient of r =0.743.Conclusion MAD ratio MAPD in the diagnosis of pulmonary artery hypertension have relatively high specificity,and the risk of an exacerbation of COPD future have prompted role in helping COPD patients with pulmonary hypertension of early detection and early treatment.

Recently, vasculogenic mimicry, a new form of tumor blood supply has been discovered,which is completely different with the classic model of tumor blood supply. It has important significance which perfect the mechanism of tumor blood supply, improve the treatment and prognosis of tumor. In the paper, its structure, mechanism, and clinical significance of tumor treatment are reviewed.

Endometriosis, an oestrogen-dependent disorder, is related to inflammation, p38 Mitogen activated protein kinases (p38 MAPK) can be activated by sex hormone and inflammatory factors, which plays an important role in many cellular reactions such as apoptosis, proliferation, inflammation and stresses, etc. Many studies showed that p38 MAPK was participated directly in regulating the pathogenesis of endometriosis. The special regulatory action of p38 MAPK on sex hormone and inflammation may help us to understand the intricate endometriosis pathological hypothesis. p38 MAPK inhibitors play a key role in the the study of endometriosis, and show great promise for the future. Blocking and regulating the expression of p38 MAPK on the signal transduction pathway level may hope to be a new strategy to prevent and treat endometriosis.

Objective To explore the efficacy of intratympanic dexamethasone injection in treating acute low-frequency hearing loss(ALHL).Methods Thirty-seven ALHL cases not responsive to intravenous dexamethasone and vasodilator medications were enrolled in the study and divided into two groups.In the treatment group,dexamethasone was injected intratympanically once per day to 18 cases for a seven-day history with unilateral ALHL and 1 case with bilateral ALHL.In the control group,18 cases with unilateral ALHL were given intravenous vasodilator medications for 7 days.All patients were followed up for 1～ 2 years.Results In the treatment group with unilateral ALHL,8 cases achieved complete recovery,7 cases achieved partial recovery and no change was observed in the other 3 cases.The efficiency was 83.3 %.2 cases showed recurrent low-frequency hearing loss during the follow-up period.One case with bilateral ALHL did not respond to the treatment and no recurrence was observed.No side effect was observed in the study.In the control group,3 cases completely recovered,5 cases partially recovered and 10 cases showed no improvement.The efficiency was 44.4%.5 cases recurred and one of them progressed to Meniere's disease.There was a statistically significant difference in efficiency of patients with unilateral ALHL between two groups(P＜0.05).Conclusion Intratympanic dexamethasone application was an effective and safe treatment option for ALHL.

Objective:To investigate the changes of occlusal plane in the process of retracting maxillary anterior teeth with different vertical traction force.Methods:The three dimensional finite element model of maxillary anterior teeth en-masse retraction by micro-implant was constructed with cone beam CT scanning and MIMICS and ANSYS software.Then the movement tendency of tooth and the changes of the maxillary occlusal plane was calculated when the vertical traction force was 0,0.5,0.75 and 1 N in the process of en-mass retraction,respectively.Results:Lingual tipping of anterior teeth,distal tipping of the first molar and the maxillary occlusal plane clockwise rotation by the retraction forces were observed.With the vertical traction force increasing,lingual tipping of anterior teeth and distal tipping of the first molar were decreased,and the occlusal plane clockwise rotation was prevented.Conclusion:The upper dentition movement and occlusal plane rotation can be changed effectively by the vertical traction with different force.When retract anterior teeth,0.5-0.75 N vertical traction force is beneficial to prevent clockwise rotation of the maxillary occlusal plane.

Objective To study the expression of dihydrodiol dehydrogenase (DD) in prostate cancer and its significance. Methods With reference to expression of ?-actin gene,the expression level of a human dihydrodiol dehydrogenase isoform (DD2) mRNA was examined in prostate cancer tissues (11 cases) and normal prostate tissues (10 cases) by reverse transcriptive-polymerase chain reaction(RT-PCR). Quantitative determination of relevant band densities was performed using densitometry-scanning techniques. Results Strong expression of DD2 mRNA was detected in prostate cancer tissures with absorbance in the range of 0.550 to 1.018 (median,0.726),and low expression of DD2 mRNA in normal prostate tissues with absorbance in the range of 0.248 to 0.420 (median,0.333). The difference of the expression of DD2 mRNA between cancer and normal prostate was significant ( P

Objective To investigate the method and the effect of posterior approach low lumbar spinal nerve root sheath decompression under microendoscope (MED-Ⅱ). Methods Thirty-nine patients with low lumbar disc herniation, accompanying severe preoperative limb numbness and radiculalgia, who were found obvious edema of nerve root with adhesion during surgery, entered the study. In the course of lumbar discectomy, a self-made mini-scalpel was used for the incision and decompression of the nerve root sheath, in which a 3～5 mm longitudinal incision was made along the dorsal side of the nerve root. Results Decompression was achieved under microendoscope (MED-Ⅱ) in all the 39 patients. Limb numbness and radiculalgia subsided completely in 17 patients within 24 postoperative hours, while the symptoms trailed off within 2 weeks following the surgery in the remaining patients. The time to complete disappearance of the symptoms was 1～14 d (mean, 6 5 d). Conclusions Minimally invasive spinal nerve root sheath incision and decompression can give a prompt relief from limb numbness and radiculalgia, improving the recovery of nervous system. Lumbar spinal nerve root sheath incision and decompression under microendoscope (MED-Ⅱ) is a safe and effective procedure.

BACKGROUND: Osteogenesis-related molecules were detected in osteosarcoma tissues, which have closely association with the occurrence, development and prognosis of osteosarcoma. OBJECTIVE: To study the expression of bone morphogenetic protein 7 (BMP-7), vascular endothelial growth factor (VEGF) and core binding factor ?1 (RUNX2) in osteosarcoma cell Lines MG63. DESIGN, TIME AND SETTING: A molecular biology observation was performed at the Central Laboratory of Changhai Hospital between March 2007 and November 2007. MATERIALS: Osteosarcoma cell line MG63 was purchased from Institute of Biochemistry and cell biology, ISBS, CSA. METHODS: Cell line MG63 was counted with blood cell counting, inoculated in 100 mL culture flask with density of 1?104/cm2, stimulated at 37 ℃ with 5% CO2 air and saturated humidity. Then adherent cultured with DMEM containing 10% fetal bovine serum. When the cells reached 70%-80% confluency, the cells were digested with 0.25% pancreatic enzyme for 5 minutes, followed by terminating the digestion with adding DMEM containing 10% fetal bovine serum, and passaged at a ratio of 1:3. MAIN OUTCOME MEASURES: The expressions of BMP-7, VEGF and RUNX2 in MG63 were detected by RT-PCR and immunohistochemistry. RESULTS: BMP-7, VEGF and RUNX2 were positive expressed in MG63. CONCLUSION: The expression of BMP-7, VEGF and RUNX2 in MG63 was confirmed by gene and protein levels, which suggested that osteogenesis-related molecules may play important roles in the development of osteosarcoma.

Objective To discuss the timing and methods of operative treatment of acetabular fractures of AO Type C (double- column fractures). Methods From February, 1999 to January, 2004, we treated operatively 46 cases of AO Type C acetabular fractures, including 23 cases of C- 1 type, 14 cases of C- 2 type, and 9 cases of C- 3 type. 15 cases were treated through ilioinguinal approach, 10 cases through improved Kocher- Langenbeck approach, and 21 cases through combined anterior and posterior approaches. There were 3 groups of patients according to the time from injury to operation: 15 cases got operation within 1st week after injury (Group A); 23 cases within 2nd week (Group B); 8 cases within/after 3rd week (Group C). All of them were checked with radiography and 3D CT scan before and after operation. Results 34 cases( 73.9% ) obtained anatomical reduction, 8 cases( 17.4% ) got imperfect reduction, and 4 cases( 8.7% ) had unsatisfactory reduction. All the patients were followed up for 1 year to 4 years, averaging 31 months. According to D' Aubigne and Postel Hip Score, joint function was rated as excellent in 32 cases( 69.6% ) , good in 5 cases( 10.9% ) , fair in 5 cases ( 10.9% ) and poor in 4 cases ( 8.7% ) . As far as reduction was concerned, there was a significant difference (P0.05). As far as joint function was concerned, there was a significant amelioration in Groups A and B compared with Group C (P0.05) between group A and Group B. Conclusions Good knowledge of AO classification of acetabular fractures combined with particular radiological data can result in correct diagnosis of Type C acetabular fractures. Operations should be carried out within 2 weeks after injury and efforts should be made to ensure anatomical reduction. To achieve good clinical results in treatment of Type C acetabular fractures, suitable approaches and correct reduction and internal methods are essential

From the treatment of respiratory failure, the method of breathing heliox is presented. This paper introduces the heliox-recirculating respirator based on ADuC848 which realizes PID control of heliox output through the measurements of the pressure in gas path, oxygen concentration, temperature and so on. The electronic measurement & control unit is described in detail.