Objective To investigate the diagnostic value of diameter ratio of pulmonary artery or ascending aorta in chronic obstructive pulmonary disease (COPD)patients with pulmonary hypertension.Methods 60 COPD patients with secondary pulmonary hypertension were selected as the study group,then 60 cases of normal pulmonary artery pressure COPD patients were selected as the control group.By comparing the pulmonary artery and aorta diame-ter ratio rose of the two groups to judge the value slow lung disease in patients with pulmonary hypertension of the resistive prompt action.Results The MAPD and MAD ratio of the study group was significantly higher than in the control group[(1.04 ±0.01)vs (0.83 ±0.02),t =12.572,P =0.000],and pulmonary artery high pressure ratio was positively correlated with the relative coefficient of r =0.743.Conclusion MAD ratio MAPD in the diagnosis of pulmonary artery hypertension have relatively high specificity,and the risk of an exacerbation of COPD future have prompted role in helping COPD patients with pulmonary hypertension of early detection and early treatment.

Endometriosis, an oestrogen-dependent disorder, is related to inflammation, p38 Mitogen activated protein kinases (p38 MAPK) can be activated by sex hormone and inflammatory factors, which plays an important role in many cellular reactions such as apoptosis, proliferation, inflammation and stresses, etc. Many studies showed that p38 MAPK was participated directly in regulating the pathogenesis of endometriosis. The special regulatory action of p38 MAPK on sex hormone and inflammation may help us to understand the intricate endometriosis pathological hypothesis. p38 MAPK inhibitors play a key role in the the study of endometriosis, and show great promise for the future. Blocking and regulating the expression of p38 MAPK on the signal transduction pathway level may hope to be a new strategy to prevent and treat endometriosis.

Recently, vasculogenic mimicry, a new form of tumor blood supply has been discovered,which is completely different with the classic model of tumor blood supply. It has important significance which perfect the mechanism of tumor blood supply, improve the treatment and prognosis of tumor. In the paper, its structure, mechanism, and clinical significance of tumor treatment are reviewed.

Objective To explore the efficacy of intratympanic dexamethasone injection in treating acute low-frequency hearing loss(ALHL).Methods Thirty-seven ALHL cases not responsive to intravenous dexamethasone and vasodilator medications were enrolled in the study and divided into two groups.In the treatment group,dexamethasone was injected intratympanically once per day to 18 cases for a seven-day history with unilateral ALHL and 1 case with bilateral ALHL.In the control group,18 cases with unilateral ALHL were given intravenous vasodilator medications for 7 days.All patients were followed up for 1～ 2 years.Results In the treatment group with unilateral ALHL,8 cases achieved complete recovery,7 cases achieved partial recovery and no change was observed in the other 3 cases.The efficiency was 83.3 %.2 cases showed recurrent low-frequency hearing loss during the follow-up period.One case with bilateral ALHL did not respond to the treatment and no recurrence was observed.No side effect was observed in the study.In the control group,3 cases completely recovered,5 cases partially recovered and 10 cases showed no improvement.The efficiency was 44.4%.5 cases recurred and one of them progressed to Meniere's disease.There was a statistically significant difference in efficiency of patients with unilateral ALHL between two groups(P＜0.05).Conclusion Intratympanic dexamethasone application was an effective and safe treatment option for ALHL.

Objective: The activity of nitric oxide synthase(NOS)in nasal mucosa of normal guinea pigs was compared with that of allergic rhinitis(AR)guinea pigs to investigate the relationship between NOS and AR. Methods: Localization of NOS in nasal mucosa of normal and AR guinea pigs was examined by means of NADPH diaphorase (NADPH d) histochemical stain. Results: Nasal mucosa of both normal and AR groups was positive for NADPH d, though the AR group reacted more strongly. Reaction was localized to the cytoplasm of glandular cell, epithelium and vascular endothelium. Conclusion: There is distribution of NOS in nasal mucosa of normal guinea pigs. The activity of NOS in guinea pig AR model was significantly stronger than that in normal group. NOS is related to AR. [

Objective: To investigate the pathogenesis of allergic rhinitis at cell level by determing basophil histamine releasability in guinea pigs and attempt to find an objective way for the diagnosis of allergic rhinitis. Methods: A model of allergic rhinitis was established after healthy guinea pigs were randomly divided into 2 groups. The basophil histamine releasability to the stimulant of concanavalin A between normal and experimental guinea pigs was compared by means of fluorometric assay of histamine. Results: Basophil histamine release to various concentrations of concanavalin A in allergic rhinitis group was significantly enhanced as compared with that in normal control ( P

Objective To study the expressions of XIAP and survivin in breast carcinoma tissues and their(value) in predicting the recurrence of breast carcinoma.Methods The expression of XIAP and survivin in 65 benign and 65 malignant breast paraffin-embedded specimens was detected by using immunohistochemical assay and the results were compared.Results The positive rate of XIAP and survivin in recurrent breast carcinoma(recurrent group) was 82.2% and 85.7% respectively,and in non-recurrent breast carcinoma tissue(non-recurrent group) was 54.5% and 45.5% respectively,and in both groups were increased significantly as compared with that of benign breast tissues(20.0%,and 13.3% respectively).The positive expression of XIAP and survivin was increased significantly in recurrent group as compared with non-recurrent group(P

Objective To investigate the factors of hospitalization expense in patients with type 2 diabetes mellitus undergoing non-emergency surgery.Methods A retrospective study included diabetic (109 cases) and control (162 cases) groups.Hospitalization expense and other observation indices were compared between two groups and subgroups.The factors that contribute to hospitalization expense were analyzed with multifactor regression analysis model.Results The median hospitalization expense was 12 014.74 yuan in the diabetic group,1.24 times than that in the control group (P =0.001).Diabetic group has higher American Society of Anesthesiologists (ASA) classification,longer wound healing time,higher postoperative infection rate,and longer hospital stay (P ＜ 0.01).Multifactor analysis revealed that the significant factors that influence the hospitalization expense were ASA classification (β =0.442,P =0.000),postoperative fasting plasma glucose (β =0.204,P =0.020),and postoperative infection (β =0.204,P =0.019).No significant difference was found in postoperative infection rate and hospitalization expense between two groups,when patients had received minimally invasive surgeries (P ＞ 0.05).Conclusions Type 2 diabetes patients have higher hospitalization expense;ASA classification,postoperative fasting plasma glucose,and postoperative infection are the main influence factors.Giving priority to minimally invasive surgeries and enhancing perioperative glucose control can help to reduce hospitalization expense in patients with type 2 diabetes mellitus.

Objective To discuss the timing and methods of operative treatment of acetabular fractures of AO Type C (double- column fractures). Methods From February, 1999 to January, 2004, we treated operatively 46 cases of AO Type C acetabular fractures, including 23 cases of C- 1 type, 14 cases of C- 2 type, and 9 cases of C- 3 type. 15 cases were treated through ilioinguinal approach, 10 cases through improved Kocher- Langenbeck approach, and 21 cases through combined anterior and posterior approaches. There were 3 groups of patients according to the time from injury to operation: 15 cases got operation within 1st week after injury (Group A); 23 cases within 2nd week (Group B); 8 cases within/after 3rd week (Group C). All of them were checked with radiography and 3D CT scan before and after operation. Results 34 cases( 73.9% ) obtained anatomical reduction, 8 cases( 17.4% ) got imperfect reduction, and 4 cases( 8.7% ) had unsatisfactory reduction. All the patients were followed up for 1 year to 4 years, averaging 31 months. According to D' Aubigne and Postel Hip Score, joint function was rated as excellent in 32 cases( 69.6% ) , good in 5 cases( 10.9% ) , fair in 5 cases ( 10.9% ) and poor in 4 cases ( 8.7% ) . As far as reduction was concerned, there was a significant difference (P0.05). As far as joint function was concerned, there was a significant amelioration in Groups A and B compared with Group C (P0.05) between group A and Group B. Conclusions Good knowledge of AO classification of acetabular fractures combined with particular radiological data can result in correct diagnosis of Type C acetabular fractures. Operations should be carried out within 2 weeks after injury and efforts should be made to ensure anatomical reduction. To achieve good clinical results in treatment of Type C acetabular fractures, suitable approaches and correct reduction and internal methods are essential

From the treatment of respiratory failure, the method of breathing heliox is presented. This paper introduces the heliox-recirculating respirator based on ADuC848 which realizes PID control of heliox output through the measurements of the pressure in gas path, oxygen concentration, temperature and so on. The electronic measurement & control unit is described in detail.