Purpose: To observe the clinical therapeutic effect in the treatment of infantile persisting diarrhea with the spine-pinching manipulation plus moxibustion.Methods: 110 cases of the sick children were randomly divided into 68 cases in the treatment group and 42 cases in the control group for comparative observation. The treatment group was treated by the spine-pinching manipulation and the control group was given the expectant treatment of western medicine. Results: The total effective rates were 97.0% and 81.0% in the treatment group and control group respectively, and the therapeutic effect in the treatment was better group than in the control group (P＜0.01). Conclusion: The treatment of infantile persisting diarrhea by the spine-pinching manipulation plus moxibustion could remarkably enhance the therapeutic effect and shorten the courses of the treatment.

The S100 protein family is a key component of damage-associated molecular patterns(DAMP), which play a vital role in regulating inflammation in the body's innate immune response. S100A8/S100A9 proteins play a wide range of antibacterial and anti-infective functions in many diseases, and promote the occurrence and development of the body's immune and inflammatory responses. In various retinal degenerative diseases, S100A8/S100A9 proteins are significantly upregulated at the transcription and translation stages, promoting the activation of inflammatory factors in ocular tissues, the activation and recruitment of immune cells such as macrophages and neutrophils, and the occurrence and development of ocular inflammation. This review aimsat explaining the biological functions of S100A8/S100A9 proteins and their roles and possible mechanisms in retinal degenerative diseases such as diabetic retinopathy, age-related macular degeneration and ischemic retinopathy.