Objective To evaluate the efficacy and safety of topamax combined with sodium valproate for treatment of refractory epilepsy. Methods A total of 110 cases of refractory epilepsy admitted and treated in our hospital from May 2010 to April 2013 were selected and randomly assigned to the observation group and the control group. The observa-tion group(55 cases) was treated by topiramate combined with sodium valproate and the control group (55 cases)was treated by topiramate alone. The clinical efficacy, EEG change and incidence of adverse reactions were compared be-tween the two groups. Results The total cases with therapeutic effectiveness were 49 in the observation group with total effectiveness rate of 89.09%. The total cases with therapeutic effectiveness were 41 in the control group with total effec-tiveness rate of 74.55%. The two groups had statistical difference in total effectiveness rate (P<0.05). The observation group and the control group also had statistical difference in excellent effectiveness rate and ineffectiveness rate (χ2=3.9111, P<0.05). 7 cases of adverse reactions were observed in the two groups during treatment, with incidence of 6.36%, including dizziness, headache, fatigue, anorexia, nausea and vomiting. The adverse reactions were gradually remitted with progress of treatment. No severe adverse reactions were observed, including rash, damage of liver, kid-ney or other important organs. The two groups were comparable in the incidence of adverse reactions,without statistical difference. Conclusion Topamax combined with sodium valproate has good efficacy for treatment of refractory epilepsy,which is worthy of clinical promotion.

Objective:To observe the effect of Yi Jin Jing(Sinew-transforming Qigong Exercises)intervention on anxiety in asymptomatic patients with Corona Virus Disease 2019(COVID-19)infection during quarantine.Methods:A total of 160 asymptomatic patients with COVID-19 infection were stratified by gender and divided into an observation group and a control group by the stratified randomization method,with 80 cases in each group.The control group was given basic nursing in the cabin,and the observation group was given additional Yi Jin Jing exercises once a day,20 min each time,and trained continuously until 1 d before leaving the cabin.The Hamilton anxiety scale(HAMA)score was compared between the two groups.Results:A total of 154 cases were included for data analysis in this study,including 74 cases in the observation group and 80 cases in the control group.After intervention,the HAMA scores in both groups increased(P<0.05),while the score in the observation group was lower than that in the control group(P<0.05).In the control group,the HAMA score of females after intervention was higher than that of males.The scores of mental anxiety and somatic anxiety in both groups were higher than those before intervention,while the score of mental anxiety in the observation group was significantly lower than that in the control(P<0.05).However,there was no statistical difference in the somatic score between the two groups(P>0.05).Conclusion:Patients with COVID-19 infection will get anxious during quarantine.Yi Jin Jing exercise can effectively reduce the aggravation of anxiety in asymptomatic patients with COVID-19 infection during concentrated quarantine.

Existing antidepressant treatments are generally suboptimal for patients with bipolar disorder(BD).Several studies have explored the efficacy of light therapy(LT)in patients with bipolar depression,along with investigating parameters,devices,and safety aspects of LT.This paper provides a review of these aspects.Numerous meta-analyses and randomized controlled trials have indicated that LT could significantly improve depressive symptoms in BD patients,with both low and high intensity white light having this effect,while the antidepressant effect of blue light remains unclear.LT takes effect rapidly,preferably in the morning,with each session lasting between 30 to 60 minutes,but there is no consensus on the most beneficial LT course for BD patients.The most commonly used device for LT is a lightbox.However further exploration is need regarding the safety of LT glasses.When LT devices that meet safety standards is selected,the overall safety of LT will be high and risk of manic or hypomanic switch will be low for BD patients.In conclusion,LT holds promise for patients with bipolar depression,and further research on LT for BD patients should be conducted to explore LT strategies and develop LT prescriptions.