1.Relationship beween cerebrospinal fluid changes and prognosis in patents with neurosyphilis
Hongkai QIU ; Weibin LIU ; Lina MEN
Journal of Clinical Neurology 1995;0(04):-
Objective To investigate the relationship between cerebrospinal fluid (CSF) changes and prognosis in patients with neurosyphilis.Methods The CSF and the clinical data of 55 syphilis patients were analysed retrospectively,including 30 neurosyphilis cases and 25 syphilis cases during incubation period.The CSF leukocyte, protein and pressure of the two groups were measured,meanwhile, rapid plasma regain circle card(RPR) and treponema pallidum particle assay (TPPA) were simultaneous determination. All cases were treated with penicillin G normally during the whole range.Two groups of patients were followed-up by telephones or outpatient department in two year and the prognosis were evaluated. Function Independent Measure (FIM) were scored at the same time.Results The seum RPR and TPPR in two group patients were all positivity CSF leukocyte and protein were higher in neurosyphilis than that of in syphilis incubation period, There was significant difference between the two groups (all P
2.Comparison of Validity of the Methods for Estimating Target Height
Weibin ZHU ; Peizheng CHEN ; Longmei QIU
Journal of Chinese Physician 2002;0(S1):-
18 years(n=160) were included. CMH method and FPH model were applied to analyse statistically final height of Shanghai children and their midparental height. Results There was a considerable disparity in stature between the Chinese and the Swedish study populations(P
4.Influence of family function and social support intervention on insulin treatment compliance in patients with diabetes mellitus
Hui QIU ; Yan WANG ; Bing LIU ; Weibin ZHANG ; Yueying WANG ; Qiujin HUANG
Chinese Journal of Modern Nursing 2016;22(3):322-326
Objective To discuss the influence of family function and social support on insulin treatment compliance in patients with diabetes mellitus. Methods A total of 368 diabetic patients diagnosed using insulin treatment were selected between March 2013 and May 2014 in outpatient department of endocrinology department. Situations of Insulin treatment compliance, family function, social support were investigated by questionnaire. Results Insulin treatment compliance were good in 202 cases (54. 9%), poor in 120 cases (32. 6%) and very poor in 46 cases (12. 5%). The cases of different levels of family function were 183 (49. 7%) with a high level, 82 (22. 3%) with a general level and 103 (28. 0%) with dereliction of duty level. The cases of low, a general and a high level of social support were 119 (32. 3%), 108 (29. 3%) and 141 (38. 3%). Multiple regression analysis showed that the main factors influencing the compliance of insulin treatment were age, education degree, marital status, occupation, monthly income, payment methods, disease duration, family function and social support. Conclusions When the scores of family function and social support are higher, the treatment compliance is higher too. The nursing staff should improve patient's family function and social support in order to improve the patients' insulin treatment compliance, so as to improve patients'quality of life.
5.GBA1 Thr408Met mutation in a patient with Parkinson’s disease
Yi ZHAO ; Junwen LI ; Chunlian JU ; Weibin QIU ; Bo ZUO ; Zhigang YANG ; Yansheng LI
Chinese Journal of Clinical Medicine 2025;32(3):524-528
GBA1 gene mutation is an important genetic risk factor for Parkinson’s disease (PD). This paper reports a case of a 43-year-old male PD patient carrying a rare heterozygous Thr408Met mutation in the GBA1 gene identified through whole-exome sequencing, leading to a diagnosis of GBA1-associated PD. The patient’s motor symptoms were primarily characterized by bradykinesia and rigidity, without significant cognitive decline. Treatment with low-dose levodopa combined with a dopamine agonist resulted in significant symptomatic improvement.
6.Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes
Jie ZHUYE ; Chen CHEN ; Hao LILAN ; Li FEI ; Song LIJU ; Zhang XIAOWEI ; Zhu JIE ; Tian LIU ; Tong XIN ; Cai KAIYE ; Zhang ZHE ; Ju YANMEI ; Yu XINLEI ; Li YING ; Zhou HONGCHENG ; Lu HAORONG ; Qiu XUEMEI ; Li QIANG ; Liao YUNLI ; Zhou DONGSHENG ; Lian HENG ; Zuo YONG ; Chen XIAOMIN ; Rao WEIQIAO ; Ren YAN ; Wang YUAN ; Zi JIN ; Wang RONG ; Liu NA ; Wu JINGHUA ; Zhang WEI ; Liu XIAO ; Zong YANG ; Liu WEIBIN ; Xiao LIANG ; Hou YONG ; Xu XUN ; Yang HUANMING ; Wang JIAN ; Kristiansen KARSTEN ; Jia HUIJUE
Genomics, Proteomics & Bioinformatics 2022;20(2):304-321
The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical micro-biome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenor-rhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.