1.Titanium Clips in the Treatment of Defects Caused by Endoscopic Mucosal Resection:Report of 62 Cases
Fangxian LI ; Zhining FAN ; Wei WEN
Chinese Journal of Minimally Invasive Surgery 2001;0(06):-
Objective To evaluate the therapeutic effects of titanium clips occlusion for the defects and complications caused by endoscopic mucosal resection(EMR).Methods Totally 62 patients with protuberant lesions in the esophagus or gastrointestinal tract(≤15 mm in diameter) were treated by EMR in our hospital.During the operation,69 lesions were cut and the surgical defects were clipped using titanium clips.The intra-and post-operative complications of the patients were reviewed.Six weeks after the treatment,the patients received re-examination by endoscopy to observe the healing of the mucosal defects.Results The 69 lesions in the 62 cases were resected completely.At each defect,1-3 titanium clips were used,no perforation or hemorrhage occurred in the patients.Endoscopy performed in 6 weeks showed that all the defects were healed without ulcer,stenosis or recurrence.The titanium clips dropped 65 of the defected mucosa.Conclusion Titanium clips is effective and safe for defects caused by endoscopic mucosal resection.
2.Design and Implementation of System for Health Examination and Health Monitoring in Medical Examination Center
Wen XIE ; Wei YU ; Kaizhou FAN ; Xutian ZHANG
Chinese Medical Equipment Journal 2009;30(7):57-58
Obiective To introduce the design and implementation of system for health examination and health monitoring according to the needs and workflow of the Health Examination Center. Methods The system has an effective configuration based on HL7 and smart client technology. Results The system can truly meet the actual needs and realize the digitizing management of the health examination center. Conclusion The system plays an important role in optimizing the wotkflow and can improve service quality and efficiency of health examination to promote digital construction in hospital.
3.National Comprehensive Cancer Network, Americal Society of Clinical Oncology and Oncology Nursing Society in the guide nursing enlightenment to our country related content
Xin PENG ; Qu WEN ; Xiaomeng LI ; Fan LIANG ; Wei CHEN
Chinese Journal of Practical Nursing 2015;31(14):1076-1079
We aimed to make comprehensive cancer care guidelines of China according to American guidelines of National Comprehensive Cancer Network,Ametican Society of Clinical Oncology and Oncology Nursing Society,and to guide clinical nurses to study and draw lessons from foreign latest guidelines,and combined with the actual situation in our country.The results of study and application were advantageous to the nursing profession,the security and interests of the patients.We should develop comprehensive cancer care guidelines of our country,eventually make nursing practice guide system of China constantly improve and perfect.
4.Clinical examination and evaluation of stereoacuity with multi-dimensional spacial perception model in children with strabismus and amblyopia
Wen, LIU ; Gang, YU ; Qian, WU ; Wen-hong, CAO ; Yun-wei, FAN ; Qi, LIN ; Hui-hui, CHU ; Ru, ZHANG
Chinese Journal of Experimental Ophthalmology 2012;30(9):806-810
Background There is multi-dimensional order of spatial stereopsis perception in human,however,current stereopsis examination is zero-order of position disparity.A multi-dimensional space perception model is very important for the detection of stereoacuity.Objective This study was to screen the deficit of zero-order,first-order,second-order multi-dimensional spatial stereopsis perception in amblyopia and strabismus children and to explore the association of zero-order,first-order,second-order spatial perception deficit.Methods Multidimensional spacial perception was examined in 79 children aged 4-14 years in Beijing Children' s Hospital.Nineteen normal children,19 children with ametropia amblyopia,12 children with anisometropic amblyopia,18 children with strabismus and 11 children with strabismus combined amblyopia were included this study.The random-dot and line spatial stereopsis perception in zero-order,first-order and second-order were examined with a new system of multidimensional space perception screening.Written informed consent was obtained from each subject or custodian before any ocular examination associated with this study.Results Absence of zero-order,first-order,second-order random-dot channel was found in 24 children (24/79,30.4%),18 children (18/79,22.8%) and 24 children (24/79,30.4%) respectively,with an average percentage of 27.9%.Absence of zero-order,first-order,second-order line channel was examined in 37 children (37/79,46.8%),37 children (37/79,46.8%),32 children (32/79,40.5%),with an average percentage of 44.7%.In the children with a deficiency of the zero-order spatial perception,the children who still remained the first-order or/and second-order spatial perception of random-dot accounted for 41.6% and that of lines accounted for 43.2%.In children without deficiency of zero-order random-dot or lines spatial space perception,deficiency of first-order and/or second-order spatial perception was in 37.5% children.Various order spatial perception deficiency was seen in children suffering from amblyopia or strabismus compared with normal group(P < 0.05).Conclusions There exists spatial perception deficiency in children with amblyopia or strabismus.The patients with zero-order spatial perception absence partially remain a first-order or/and second-order spatial perception;while the patients with normal zero-order spatial perception might have first-order or second-order spatial perception deficiency.The multi-dimensional space perception model has a directive role for the training of visual information process and the treatment of spatial perceptual learning in children with amblyopia or strabismus.
5.Isolation of endophytic fungi from Macleaya cordata and screening of sanguinarine-producing strains.
Chang-lil MIN ; Xue-jun WANG ; Meng-fan ZHAO ; Wen-wei CHEN
China Journal of Chinese Materia Medica 2014;39(22):4288-4292
Endophytic fungi were isolated from Macleaya cordata growing in Dabie Mountain by agar-block method, and then the endophytic fungi were grouped into different types based on their morphological characteristics, and thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) were employed to determine whether the metabolic substances contained sanguinarine or not, and then preliminarily identified by morphological method. The results showed that the leaves hosted the largest number of endophytes (96 isolates) followed by the stems (57 isolates) and finally the roots (28 isolates), respectively. Based on morphological characteristics the endophytic fungi were grouped into 26 types in our study. TLC and HPLC results showed that there was sanguinarine in the metabolic substances of BLH 51 strain. According to the morphological characteristic, the BLH 51 strain was identified as Fusarium proliferatum. All these indicated that the medicinal plant M. cordata harbors abundant endophytes, which could be a new source for the search of active secondary metabolites.
Benzophenanthridines
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metabolism
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Endophytes
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isolation & purification
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Fungi
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isolation & purification
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Isoquinolines
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metabolism
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Papaveraceae
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metabolism
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microbiology
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Plant Leaves
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microbiology
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Plant Roots
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microbiology
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Plant Stems
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microbiology
6.Research on Chinese medicine pairs (II)--Their data mining.
Er-Xin SHANG ; Wen-Lin LI ; Liang YE ; Wei ZHOU ; Yu-Ping TANG ; Xin-Sheng FAN
China Journal of Chinese Materia Medica 2013;38(24):4191-4195
Data mining technology has become a powerful tool in traditional Chinese medicine (TCM) research. In this paper, based on the principle and basic requirements of data mining, the mining methods and procedures were described. And then the application of data mining technology in Chinese medicine pair research was classified and summarized, such as the compatibility characters, characteristic pairs, dosage-effect relationship and property compatibility, which provide the direction and data base for modern research of Chinese medicine pair.
Cluster Analysis
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Data Mining
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methods
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Drug Interactions
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Drug Prescriptions
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Medicine, Chinese Traditional
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methods
7.Dynamic monitoring risk of anti-hepatoma new drug development.
Jing ZHANG ; Wei FAN ; Hong-Fa LI ; Shu-Li MAN ; Zhen LIU ; Wen-Yuan GAO
China Journal of Chinese Materia Medica 2014;39(20):4050-4053
Risk monitoring of new Chinese patent anti-hepatoma drugs is tracking recognized risks and residual risks, identifying emerging risk and ensure the implementation of the plan, estimating the process of reducing effectiveness. The paper is mainly through understanding the status of Chinese patent anti-hepatoma drugs, the content, characteristic and analysis method of dynamic risk monitoring, and then select the risk control indicators, collect risk information. Finally, puts forward the thought of anti-hepatoma drugs listed evaluation in our country, and try to establish the model of dynamic risk management of anti-hepatoma drugs.
Antineoplastic Agents, Phytogenic
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adverse effects
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economics
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therapeutic use
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Carcinoma, Hepatocellular
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drug therapy
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Drug Discovery
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economics
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legislation & jurisprudence
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organization & administration
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Drug and Narcotic Control
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economics
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legislation & jurisprudence
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organization & administration
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Drugs, Chinese Herbal
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adverse effects
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economics
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therapeutic use
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Humans
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Liver Neoplasms
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drug therapy
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Product Surveillance, Postmarketing
8.Flavonoids from root of Machilus wangchiana.
Wei CHENG ; Wen-Dong XU ; Xiao-Na FAN ; Jian-Gong SHI
China Journal of Chinese Materia Medica 2014;39(19):3794-3797
Twelve flavonoids were isolated from an ethanol extract of Machilus wangchiana by a combination of various chromatographic techniques including column chromatography over silica gel and Sephadex LH-20 and reversed-phase flash chromatography and HPLC. Their structures were identified by spectroscopic data analysis (IR, MS, and NMR) as (+)-catechin (1), (-)-epicatechin (2), 3'-O-methyl-(+)-catechin (3), 3'-O-methyl-(-)-epicatechin (4), 3, 5, 7, 2', 5'-pentahydroxy flavan (5), (-)-naringenin (6), (-)-eriodictyol (7), (-)-liquiritigenin (8), (2R,3R)-(+)-dihydrokaempferol (9), (2R,3S)-(-)-dihydro- kaempferol (10), (2R, 3R)-(+)-taxifolin (11), and quercetin (12). Compounds 1-10 are isolated from the genus Machilus for the first time.
Drugs, Chinese Herbal
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chemistry
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Flavonoids
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chemistry
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Lauraceae
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chemistry
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Mass Spectrometry
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Molecular Structure
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Plant Roots
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chemistry
9.The effect of HIFU ablation combined with UCA on normal tissue around VX2 liver tumor in rabbits
Zhiyong FAN ; Zhenshun SONG ; Wei ZHENG ; Sheng HUANG ; Fuqin ZHANG ; Wen LUO ; Xiaodong ZHOU
Chinese Journal of General Surgery 2008;23(5):364-367
Objective To explore the optimized range of normal tissue ablation around the tumor by HIFU in combination with UCA for VX2 liver tumors in rabbits. Methods In this study,51 rabbit models with implanted fiver VX2 tumors were randomly divided into 3 groups:ablating the tumor only(group A)、ablating the tumor and 2 mm eircumferential normal tissue(group B)、and 4 mm normal tissue around the tumor(group C).After HIFU+UCA treatment,the pathology of the targeting tissues,the level of serum ALT,the metastases in the liver、lungs and abdominal cavity,and the survival time were compared with each other. Results After treatment coagulative necrosis was observed in all the target tissues.Serum ALT level between each two groups were statistically different on d3 and d5(F=12.933、18.37,P<0.01、<0.01),and the level of ALT in group C was the hightest.The ALT level in group A was significantly higher than group B or group C on the 14th day(F=17.2,P<0.01).Metastases in group A was significantly higher than group B or group C,and there were no statistically different between group B and C (P=0.353、0.332、0.380).The survival time both in group B and group C were significantly longer than group A(48±13.6,51±12.1 vs 29±5.4),and there were no statistically difference between group B and C(P>0.05). Conclusions Tumor eradication can be significantly promoted when 2mm normal liver tissue around the tumor is ablated by HIFU+UCA.
10.Monitoring rehabilitation system for the cervical spine based on computer software
Na CHEN ; Jin FAN ; Wei WANG ; Jianming WANG ; Jin WEN ; Xinling SHI
Chinese Journal of Tissue Engineering Research 2008;12(39):7755-7758
BACKGROUND:Conventional rehabilitation evaluation call not provide more objective data for analysis,so all innovative method to monitor rehabilitation of the cervical spine is introduced.OBJECTIVE:The monitoring rehabilitation system of the cervical spine develops independently under Visual Basic 6.0 environment.It can gather both video and photos at dynamic and static states.According to the suitable feature points of the video,the system could calculate characteristic parameters,such as moving angles,distances,speed,acceleration,and integral curves.Thus,the system could create patients'database.RESULTS:The system could calculate different kinds of patients'characteristic parameters through data recording.Through the objective comparison of characteristic parameters,the turning flexibility of head and controlling capability for head turning could be reflected.CONCLUSl0N:The design is an innovation in the monitoring rehabilitation systems of the cervical spine.It makes up the shortcomings of conventional rehabilitation evaluation and objectively reflects the rehabilitation status of patients.