B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation. However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmune disorders. In the paper, we introduced the mechanisms of BLyS and a proliferation-inducing ligand (APRIL) regulating T cell responses and their roles in rheumatoid arthritis (RA).

Objective: To evaluate the effectiveness of minocycline at subantimicrobial dosage in the treatment of experimentally induced periodontitis in rats.Methods: Periodontitis was induced by silk ligature technique on 4 second molars in each of 16 adult male Sprague-Dawley rats and the animals were fed with 100 g/L sucrose drink. The rats were divided into 2 groups: (1)periodontitis group without treatment;(2)treatment group, the rats with periodontitis were treated by systemic administration of minocycline at 5 mg/(kg?d).Another 8 normal rats were used as the controls. Assessment was carried out at day 28 and 56 using a number of different visual, histological and ultrastructure approaches.Visual assessment included tooth mobility(TM), gingival index(GI), and alveolar bone loss. Histological examination included monocyte effusion,resorption lacunae with osteoclasts and percentage of the periodontal collagen.The collected data were statistically analyzed using variance test.Results: Systemic administration of minocycline at subantimicrobial dosage can significantly reduce GI, TM, resorption lacunae with osteoclasts and alveolar bone loss either at day 28 or at day 56; significantly inhibited monocyte effusion and the collagen degradation in the periodontium at day 56 in rats with periodontitis. Conclusion: Minocycline at subantimicrobial dosage may decrease alveolar bone loss and osteoclasts formation in periodontium with periodontitis.

Drug treatment is one of the most important parts in t he therapeutics of periodontal disease. This review discusses the purpose, signifi cance、pharmacological mechanisms, administration methods and announcements of c linic medication in periodontal disease and summarized clinical commonused drug as well as the reseach progress in drug therapeutics of periodontal disease.

Objective To study the effects of laparoscopic radical gastrectomy for gastric cancer on serum inflammatory cytokines and intestinal barrier function in patients.Methods Retrospective analysis was used to investigate a total of one hundred and forty gastric cancer patients in Ezhou Central Hospital from January 2014 to September 2016,including 66 cases with laparoscopic radical gastrectomy (laparoscopic group) and 74 cases with traditional open radical gastrectomy (traditional group),the perioperative indexes,inflammatory factors and intestinal barrier function of the two groups were compared.Results In the laparoscopic group,the amount of bleeding loss in the laparoscopic group ((86.8 ± 15.2) ml),the incision length ((6.2 ± 1.4) cm),the first anal exhaust time ((3.0 ± 0.6) d),the fluid diet time ((4.6 ± 0.9) d),the postoperative hospitalization ((8.8 ± 1.7) d) were all lower than those in the traditional group ((158.2±25.0) ml,(16.3±2.7) cm,(3.6±0.7) d,(5.1±0.8) d,(10.3±2.5) d),the differences were statistically significant (P=0.000,0.000,0.000,0.014,0.001);the operation time of the traditional group was (196.5±27.8) min,the number of lymph nodes was (21.6±2.8),compared with those in the laparoscopic group ((192.5±30.3) min,(22.0±3.1),P=0.421,0.137).The levels of WBC,IL-6,CRP,TNF-ɑ,COR,plasma D-lactic acid and diamine oxidase in the laparoscopic group were lower than those in the traditional group (P=0.000).Conclusion The effect of laparoscopic radical gastrectomy on serum inflammatory cytokines and intestinal barrier function in patients is not obvious.

Objective:To compare the clinical factors and physical parameters between 3-fields and 4-field 3-dimensional con-formal radiotherapy(3DCRT)for mid-thoracic or upper-thoracic esophageal carcinoma.Methods:Patients with mid-thoracic or upper-thoracic esophageal carcinoma were chosen at random and treated with 3DCRT.Contouring and treatment planning were performed with VARIAN Eclipse treatment planning system(TPS).The target volume was determined according to guidelines from ICRU Report No.50.The three-beams treating plan and the four-beams treating plan were performed and a 8mm isotropic mar-gin was added for the planning target volume(PTV)in beam setting.The different plans were evaluated with dose volume histograms(DVH)in terms of dose coverage of PTV and protection of organs at risk(OAR).The prescribed dose was 60 Gy/30 F to the PTV.Results:There was no significant difference in the dose coverage to PTV and the explored dose to spinal cord with the two model of 3DCRT.When the three-beams treating plan was compared with four-beams treating plan,lungs V20 and V30 were significantly better,and at the same time lungs V5 was higher.Conclusions:3-fields 3DCRT is better than 4-fields 3DCRT with lower lungs V20 and V30 so as to prevent acute radial injury of lungs in radiotherapy of mid-thoracic or upper-thoracic esophageal carcinoma.

The diagnosis of the hip diseases and the judgment of the treatment are based on the measurement parameters with X-rays that mainly defined as anterposterior pelvis radiographs of the hip joint.The data of the measurement changes in different ages due to the growth and development of children's bodies.There are varies of parameters attempt to improve the evaluation of the hip joint.The review focuses on the Chinese and English literature since 1930s,and summarizes the introduction of the history and current condition,modified progress of methods and data analysis of measuring results.

Cerebral Cortex ; growth & development ; physiology ; Evoked Potentials, Visual ; physiology ; Humans ; Infant, Newborn ; Infant, Premature ; growth & development ; Sensory Thresholds ; physiology ; Vision, Ocular ; physiology ; Visual Acuity ; physiology ; Visual Perception ; physiology

Biliary tract cancer(BTC) is a malignart tumor which originates from biliary epithelia.Most patients with BTC present locally advanced stage or distant metastasis.Although the standard systemic chemotherapy approaches are emerging,the prognosis remains poor.Combination of gemcitabine and cisplatin can significantly prolong survival for patients,which is the standard treatment for locally advanced or metastatic BTC.Application of molecularly targeted therapies in advanced BTC is the new trend of clinical research.

In view of the increased incidences of cardiac arrest outside hospital year by year and younger tendency of the patients,foreign medical education practice showed that school-age children accepting cardiopulmonary resuscitation (CPR) skill training will benefit most from this survival skill in the future.This article elaborated on the meaning and methods of promoting CPR training in primary and middle school based on the present situation of CPR in order to promote its further development.

Objective To investigate the clinical effect of alendronate sodium on bone metabolism and bone mineral density (BMD) for treating the elderly female with osteoporotic distal radius fractures.Methods Ninety elderly female with osteoporotic distal radius fractures patients were divided into treatment group and control group with 45 cases each according to the method of random number list.The two groups were given the medication treatment after 3 d of external fixation stenting.The control group was given calcium dimension D and the treatment group was given alendronate sodium and calcium dimension D.The course of treatment was 6 months.Before and after treatment,the BMD and bone metabolism [bone alkaline pbosphatase(BALP),tartrate-resistant acid phosphatase-5b(TRACP-5b)] were detected in both groups.The wrist function of two groups was evaluated.Results Before treatment,the level of BMD of treatment group and control group were (0.472 ± 0.157),(0.519 ± 0.173) g/cm2,there was no significant difference (P ＞0.05).After treatment,the level of BMD of treatment group and control group were (0.893 ±0.298),(0.571 ± 0.184) g/cm2,the BMD of treatment group after treatment was significantly higher than that before treatment and control group after treatment(P ＜ 0.05).The level of BMD of control group after treatment had no significant difference compared with before treatment (P ＞ 0.05).Before treatment,the level of BALP,TRACP-5b of treatment group and control group were (53.76 ± 17.92),(5.61 ± 1.87) U/L and (51.86 ± 17.29),(5.54 ± 1.85) U/L,the level of BALP,TRACP-5b after treatment had significant difference compared with before treatment and control group after treatment (P ＜0.05).There was no significant difference in control group before treatment and after treatment (P ＞ 0.05).The good rate of rehabilitation of wrist function in treatment group was 91.1％ (41/45),significantly higher than that in control group [51.1％ (23/45)] (x2 =17.524,P ＜0.01).Conclusions The alendronate sodium has a role to suppress bone resorption and increase BMD.It can promote the recovery of wrist function.