1.Protective effects of jujube polysaccharide on liver injury model mice induced by ethionine or paracetamol
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(08):-
Objective: To explore the protective effects of jujube polysaccharide on liver injury model mice induced by ethionine and paracetamol. Methods: Liver injury mice model was induced by gavage with ethionine suspension or intraperitoneal injection of parcharide. ALT levels in serum and liver histopathological changes were measured, the protective effect of jujube polysaccharide on liver injury model mice induced by ethionine or paracetamol was observed. Results: Mice liver injury model can be successfully established by gavage with ethionine or intraperitoneal injection of paracetamol. High and low-dose jujuba polysaccharide and the glucurolactone groups can significantly lower the ALT levels in serum and significantly improve pathological changes in liver injury model. Conclusion: Jujube polysaccharide had good protective effects on liver injury model mice induced by ethionine or paracetamol.
2.Value of CT Scanning in Diagnosis of Pancreatic Carcinomal and Its Clinical Significance
Chinese Medical Equipment Journal 1989;0(04):-
Objective To evaluate the CT manifestation of pancreatic carcinoma proved by patholoical results. Methods The patients were supine. Both plain and three-phase dynamic contrast-enhanced CT scan were performed. 100 ml of Ominipaque was injected at a rate of 2~4ml/s, with 5~10 mm slice thickness and interval. Results CT scanning clearly showed the direct signs or indirect signs of pancreatic carcinomal, which include: pancreatic mass, obstructive dilatation of the bile duct and pancreatic duct, the visualization of the abnormal large peripancreatic vessels, lymph node metastasis, etc. Conclusion Plain CT scanning shows clearly manifestation of pancreatic carcinomal and the surrounding tissue, and three-phase dynamic contrast-enhanced CT scan can clearly display the tiny changes of pancreatic parenchyma. Therefore it is valuable for diagnosis of pancreatic carcinomal.
3.Efficacy evaluation of the resection of nasal inverted papilloma under nasal endoscope
China Medical Equipment 2016;13(8):60-62,63
Objective:To evaluate the efficacy of the resection of nasal inverted papilloma (NIP) under endoscope.Methods: A total of 100 patients with NIP from April 2008 to December 2013 in our hospital were randomly divided into endoscopic surgery group (endoscopic group) and conventional surgery group (conventional group), each with 50 cases. All patients were followed up for 2 years, whose recurrence, complications and satisfaction were observed. Results: The patients were followed up for 2 years, and the recurrence rate between the two groups was not statistically significant (x2=0.96,P>0.05). The traditional group had a higher incidence of complications than the endoscopic group, and the difference was statistically significant (x2=4.16,P<0.05). Endoscopic patients’ satisfaction was higher, and the difference was statistically significant (x2=5.02,P<0.05).Conclusion: The resection of (NIP) under endoscope can reduce the incidence of complication, improve patient satisfaction, and will not increase the recurrence rate, which is an effective means of treatment to the NIP.
4.Correlations of endoplasmic reticulum stress and cancer drug resistance
Yuanyuan YAN ; Miao HE ; Mingjie WEI
Chinese Pharmacological Bulletin 2015;(4):461-464
Endoplasmic reticulum is an important organelle in eu-karyotic cells.Endoplasmic reticulum stress (ERS)is usually triggered under cell hypoxia,carbohydrate undersupply or medi-cal treatment.Now,present studies show that ERS could activate several cell signal pathways and the UPR pathway is most widely researched.When UPR activates cell signal pathway,it can reg-ulate cancer drug resistance by involving with DNA damage re-pair,apoptotic suppression and autophagy.
5.Role of hypoxia-induced factors in cancer development mediated by cancer stem cells
Linlin WANG ; Minjie WEI ; Miao HE
Tianjin Medical Journal 2015;(6):690-693
Hypoxia and hypoxia-induced factors (HIFs) are main regulators for tumor stem cells, metastasis-initiating cells and their differentiated progenies to adapt to the environment which lacks oxygen and nutrient in the process of cancer development. HIFs are up-regulated in many tumors, including leukemia, glioblastoma, melanoma, prostate cancer, breast cancer and pancreatic cancer, in where they are especially highly expressed in hypoxic regions. HIFs activation can induce expression of numerous stem cell related genes and multidrug resistance genes, which may play important roles in tumour and stem cell-mediated self-renewing, energy metabolism alternation, invasion, metastasis, angiogenesis and treatment resis?tance of neoplastic cells. Consequently, it will provide new clues for cancer therapy after investigating the role of HIFs in tar?geted regulation and metabolic pathway modulation in various stem cell-mediated tumor cells.
6.The Construction of the Continuous Adding Test for Nationwide Conscription
Wei XIAO ; Danmin MIAO ; Jingjng GONG
Chinese Mental Health Journal 2002;0(08):-
Objective: To develop the continuous adding test for Nationwide Conscription.Method: The computer-based continuous adding test was developed and was administered to 24019 recruited young people among China and 1900 new recruits. When the 3-month-depot training finished, the 228 supervisors of the soldiers were investigated on the soldiers' working performance based on intelligence. Through the data, the test mode and cut-off scores were developed, and the reliability and validity was analyzed. Results: the cut-off scores were that finishing 26 items successfully in 120 seconds and the correct rate was higher than 30%. The retest reliability was 0.78 and the academic statues and the predicting congruence rate of the test was 94.7%.Conclusion:The continuous adding test was applicable as one of enlistee's primary qualification test.
7.Psychological Selection of Pilots in Civil Aviation with Uchida-Kraepelin Test
Wei XIAO ; Danmin MIAO ; Jingshen WANG
Chinese Mental Health Journal 1991;0(04):-
Objective: To investigate the relationship between score of Uchida-Kraepelin test, achievement and stability of emotion Method: 353 cadets received Uchida-Kraepelin test and EPQ, their academic achievement and flying performance were also recorded Results: According to Uchida-Kraepelin test, those with high ability and low disorder had better flying performance than those with low ability and high disorder (t=2 23, P
8.Effect of conjugated linoleic acid on reducing obesity in obese Wistar rats
Hongqi SHI ; Jinlai MIAO ; Wei JIANG
Chinese Journal of Marine Drugs 2000;0(06):-
To explore the effects of dietary conjugated linoleic acid(CLA) on body fat accumulation in male Wistar rats. The obese rat model was established by feeding high lipid forage. The rats were fed a semi-purified diet containing 0.5,1.0,3.0g?kg -1 CLA for 36 days. Low dose group, middle dose group and high dose group all could remarkably reduce the gain of body weight. Low dose group could reduce the body adipose, middle and high dose group could remarkably decrease the body adipose. There were significant differences in the fat and protein contents in the rats thigh between the control group and the group fed high dose CLA. These results suggested that CLA can reduce the body fat in obese Wistar rats.
9.A Follow-up Study on Recovery Process of Postpartum Depression
Xin ZHANG ; Wei XI ; Rujuan MIAO
Chinese Mental Health Journal 1988;0(06):-
Objective: To explore the recovery process and the influence factors of post-partum depression (PPD) .Methods:22 women with PPD and 34 women of non-PPD were investigated with the Edinburgh Postnatal Depression Scale (EPDS) and the Delivery Woman General Situation Questionnaire (DWGSQ) at 18 months and 30 months after childbirth.Results:The EPDS scores of PPD (11.27?3.49 at 18 months;10.91?4.59 at 30 months) were significantly higher than that of non-PPD (7.59?3.83 at 18months;7.47?4.09 at 30 months) (t 1=3.636, P 1
10.The Effect of 32h Sleep Deprivation on the Ability of Mental Rotation
Wei WANG ; Xufeng LIU ; Danmin MIAO
Chinese Mental Health Journal 1989;0(03):-
Objective: To explore the effect of 32h sleep deprivation on the ability of mental rotation. Methods: During 32h sleep deprivation, 8 healthy male college students were tested polygon mental rotation tests and POMS tests at 0800?2000?2400?0200?0400?0600?1000 and 1400 hour. Results: During sleep deprivation, the performance of polygon mental rotation test was decreasing significantly and it reached the bottom on SD24 (p