OBJECTIVE:To observe the effects of praeruptorin A for brachial plexus block anesthesia in patients receiving up-per extremity fractures surgery. METHODS:68 patients receiving upper extremity fracture surgery were randomly divided into trial group and control group with 34 cases in each group. Trial group was given praeruptorin A 0.2 mg/kg intravenously before brachial plexus block anesthesia,and control group was given equivalent volume of 0.9% sodium chloride injection. The anesthesia induc-tion time,the pain reflex disappearance time and postoperative recovery time were compared between 2 groups,and hemodynamic parameters and RPP were recorded in 2 groups before anesthesia (T0),immediately after anesthesia (T1),5 min after anesthesia (T2),10 min after anesthesia (T3),20 min after anesthesia (T4) . RESULTS:Anesthesia induction time,pain reflex disappear-ance time and postoperative respiratory recovery time in trial group were all significantly shorter than in control group,with statisti-cal significance(P<0.05). SBP,DBP,HR and MAP of trial group were lower than those of control group at T2,T3,T4,with sta-tistical significance(P<0.05). RPP of trial group was significantly lower than that of control group at T1,T2,T3 and T4,with sta-tistical significance (P<0.05). CONCLUSIONS:For brachial plexus anesthesia of upper extremity fractures surgery,preoperative application of praeruptorin A can shorten anesthesia induction time,pain reflex disappearance time and postoperative respiratory re-covery time,and reduce the fluctuation of hemodynamics.

Objective To explore the operation effect of isometric reconstruction of the medial patellofemoral ligament with the semitendinosus tendon and direct suture rehabilitation of the medial patellofemoral ligament in the treatment of patellar dislocation,and provide some reference for the surgical treatment of this disease.Methods Forty patients with patellar dislocation included 20 patients with suture repair (suture group) and 20 patients with reconstruction (reconstruction group).The erythrocyte sedimentation rate,C-reactive protein were determined at 3,14 d after operation in two groups.The congruence angles (CA),lateal patellofemoral angle (LPA),lateral patellar displacement(LS) before and after operation,knee joint function,efficacy after operation were observed and compared.Results There was no significant difference in CA,LPA,LS between two groups (P ＞ 0.05).CA,LPA,LS after operation were improved compared with before operation in two groups [suture group:(9.13 ± 1.88)° vs.(16.50 ±2.83)°,(8.48 ± 1.19)° vs.(-1.28 ± 2.12)°,(0.52 ± 0.43)° vs.(0.78 ± 0.32)° ;reconstruction group:(6.69 ± 1.83)° vs.(16.95 ±3.17)°,(6.24 ± 1.33)° vs.(-0.91 ±2.00)°,(0.32 ±0.23)° vs.(0.70 ±0.16)°],and there was significant difference (P＜ 0.01).The improvement of CA,LPA,LS in reconstruction group were better than that in suture group,and there was significant difference (P＜ 0.01).The knee joint function score by Lysholm was (38.27 ± 17.06) scores in suture group,(79.44 ±9.86) scores in reconstruction group,and there was significant difference (P ＜ 0.05).There was no significant difference in the erythrocyte sedimentation rate,C-reactive protein at 3,14 d after operation between two groups (P ＞0.05).Conclusions The operation effect of isometric reconstruction of the medial patellofemoral ligament with the semitendinosus tendon method is better than the direct suture rehabilitation of the medial patellofemoral ligament method,the former can effectively restore the relationship between patella and femoral trochlea,and cure the dislocation of patella from the root.

Objective To evaluate the hemorrheological changes after tourniquet deflation.Methods Twenty rabbits were subjected to lower extremity tourniquet inflation for 3 h. Venous blood samples were taken before tourniquet inflation and 2min after tourniquet deflation for measurement of hemorrheological parameters: low-shear viscosity and high-shear viscosity of whole blood; plasma high-shear viscosity , hematocrit; fibrinogen; aggreability,deformability and stiffness of erythrocyte; and blood sedimentation K value. The levels of parameters before tourniquet inflation served as baseline values. The gastrocnemius muscle samples were taken before tourniquet inflation and 5 min after torrniquet deflaion for observation of ultrastructure of small blood vessel.Results Compared with the baseline values, the levels of low- and high- shear viscosities of whole blood, plasma viscosity, fibrinogen, blood sedimentation K value, and aggreability and stiffness of erythrocyte increased significantly (P

Objective To explore the influence of intermittently inhaled budesonide on wheezing improvement and recurrent in infants,assess their body height and weight development status.Methods 138 wheezing infants were selected.They were randomly divided into the treatment group and the control group,69 children in each group.The treatment group received budesonide therapy when upper respiratory infection symptoms infection,the control group was given ribavirin injection spray treatment.After two weeks treatment,the number of severe wheezing and systemic corticosteroids were observed,the asthma relapse frequency in one year and height and weight were assessed.Results The severe wheezing number and the application of systemic corticosteroids number of the treatment were 1 case (1.50%)and three cases (4.35%),which were lower than the control group 8 cases (11.59%)and 11 cases (15.94%).The difference was statistically significant (χ2 =8.71,P <0.05).The frequency of wheezing within one year of the treatment group was (2.39 ±0.41)times,which was lower than (4.56 ±0.45)times of the control group, the difference was statistically significant (t =9.06,P <0.05).Comparison of height and weight of the two groups after one year,the differences was not statistically significant (t =1.45,1.18,all P >0.05).Conclusion Budesonide in the treatment of intermittent wheezing infants can significantly improve the wheezing and reduce the use of systemic corticosteroids,reduce the relapse rate.It has no effect on the growth and development of infants.

● AIM: To explore the role that hepatocyte growth factor plays in proliferative vitreoretinopathy (PVR) after retinal detachment.● METHODS: The contents of hepatocyte growth factor in subretinal fluid (SRF) in 49 cases with retinal detachment were measured with enzyme-linked immunosorbent assay.● RESULTS: With the worsening of PVR and vitreous opacity and prolonging of disease course, the content of hepatocyte growth factor increased (P＜0.05), the difference being statistically significant.● CONCLUSION: The change of hepatocyte growth factor in SRF had a close relation ship with the occurrence and development of PVR after retinal detachment.

Diamicron group. Conclusion Modified Taohe Chengqi Decoction and its diferent extractions maybe effective on raising or stabilizing the activity of Na+-K+-ATPase and Ca2+-ATPase in cadiocyte of diabetic rats, so it could prevent myocardium hypertrophy and patho-change by heart function failure in variably extent. Ethyl-acetate group and n-butyl alcohol group showed rather good effect among these extractions.

OBJECTIVE:To promote the education and research of social pharmacy in China METHODS:This article introduces the definition of social pharmacy,the history and current situation in foreign countries,and to analyse the history and development of pharmacy administration in China RESULTS & CONCLUSION:Some preliminary suggestions about the promotion of education and research of social pharmacy in China are put forward

Objective To study the mechanism of different forms of ST-segment elevation in acute myocardial infarction(AMI),and to investigate the distribution of its traditional Chinese medicine (TCM)syndrome types.Methods Two hundred and twelve hospitalized AMI patients with ST-segment elevation from March of 2015 to July of 2017 were divided into group A and group B.Group A had 102 cases with the elevation of concavity of STsegment,and group B had 110 cases with the elevation of arch of ST-segment.The correlation of ST-segment elevation in different forms with TCM syndrome types was analyzed.Results (1) Patients of group B were usually male,young and middle-aged,with or without short-term medical history of coronary heart disease,and coronary angiography results indicated the stenosis or occlusion of the vessels without collateral circulation.Patients in group A were usually female,aged,with medical history of coronary heart disease,and coronary angiography results indicated the existence of collateral circulation.(2) Group A was dominated by Qi-deficiency and blood-stasis syndrome,and the frequency of its syndrome types was in decreasing sequence:Qi-deficiency and blood-stasis syndrome,Qi-yin deficiency syndrome,heat-toxicity and blood-stasis syndrome,phlegm blended with bloodstasis syndrome,syndrome of cold stagnation in heart vessels.Group B was dominated by heat-toxicity and bloodstasis syndrome,and the frequency of its syndrome types was in decreasing sequence:heat-toxicity and bloodstasis syndrome,Qi-deficiency and blood-stasis syndrome,Qi-yin deficiency syndrome,syndrome of cold stagnation in heart vessels,phlegm blended with blood-stasis syndrome.The difference of the distribution of syndrome types was significant between the two groups (P ＜ 0.01).(3) In respect of the differentiation of deficiency and excess syndromes,group A was dominated by deficiency interweaved with excess syndrome,while group B was dominated by excess syndrome.The difference of the distribution of deficiency and excess syndrome was significant between the two groups (P ＜ 0.01).Conclusion AMI patients with different forms of ST-segment elevation have different TCM syndrome types.The investigation results will provide a new vision for the clinical trial of AMI treated with Chinese medicine integrated with western medicine,and will supply evidence for the syndrome differentiation and treatment of AMI patients with different forms of ST-segment elevation,which will contribute to enhancing clinical efficacy,saving life and improving prognosis.

Objective:To obtain the optimal conditions for separating catalpol from leaves of Rehmannia by selecting appropriate macroporous adsorption resins.Methods:The detection indication was the content of catalpol, which was determined by HPLC method. Twelve different kinds of macroporous adsorption resins were studied on the static capacity of adsorption and desorption, and H103 resin was selected for the research of separation and purification.Results:The H103 resin had a good capacity for adsorption and desorption.The best process of purifying catalpol by H103 resin was 1mg/ml concentration, the adsorption rate of 1-2 BV/h,the flow rate of 1-3 BV/h, and 8 BV with 10% alcohol.Conclusion:The method is simple and available, which can simplify the production process and lower costs.

Background and purpose:Physical and psychological trauma has been a challenge for both clinician and patients with breast cancer after modified radical mastectomy,and now more and more patients have begun to accept breast reconstruction,especially Ⅰ stage reconstruction after surgery.The aim of our study was to investigate a breast reconstruction procedure that can not only achieve radical tumor excision but also retain the aesthetic appearance of breast.Methods:15 patients from January 2006 to April 2007 were enrolled with early stage breast cancer have received surgical treatment with conservation of breast skin,breast tissue excision and axillary lymph nodes;latissimus dorsi muscle flap has been used for breast reconstruction.Results:The results of the 15 cases:excellent in 11 cases(83.3%),good in four cases(16.7%).Conclusions:Immediate breast reconstruction after radical mastectomy with conservation of skin has shown good results in terms of aesthetic appearance of breast,this procedure has been proved to be a safe and feasible method of treatment for the patients with early stage breast cancer.