Objective To investigate the effect of Astragalus membranaceus on the antioxidant capacity and liver and kidney function in patients with chronic schizophrenia and metabolic syndrome.Methods 110 cases of patients with chronic schizophrenia and metabolic syndrome were selected as subjects.They were randomly divided into the control group and the observation group by random number table method.Both groups were treated with routine antipsychotic drugs, and the observation group were additionally treated with Astragalus injection, once per day.10~14 d as a course of treatment, they were treated for a total of 6 courses.The antioxidant capacity and the liver and kidney function were compared between the two groups.The mental symptoms was evaluated with the positive and negative symptoms scale(PANSS).Results After treatment, the antioxidant capacity of the two groups was significantly increased while MDA was significantly decreased, and the changes were more obvious in observation group than the control group.After treatment, indexes of liver and kidney function were significantly increased.Except BUN and SUA, the other indicators were better in the observation group than the control group(P<0.05).After treatment, PANSS score (61.4±7.8)in the control group was significantly higher than that of the observation group(54.5±8.2)(P<0.05).Conclusion Astragalus membranaceus can be used as an assisted drug for treating chronic schizophrenia and metabolic syndrome.It can effectively improve the antioxidant capacity, reduce the damage to liver and kidney function and improve symptoms of mental illness, so as to improve the quality of life.

OBJECTIVETo compare the difference in the clinical efficacy on mild and moderate female stress urinary incontinence (FSUI) between transcutaneous acupoint electrical stimulation and oral administration of midodrine hydrochloride tablets.

METHODSNinety cases of mild and moderate FSUI were randomized into an observation group and a control group, 45 cases in each one. In the observation group, the transcutaneous acupoint electrical stimulation was applied to Ciliao (BL 32), Shenshu (BL 23), Zigong (EX-CA 1), Guanyuan (CV 4) and Qihai (CV 6), once a day. In the control group, midodrine hydrochloride tablets were prescribed for oral administration, 2. 5 mg per treatment, three times each day. The duration of treatment was 4 weeks. The score of international consultation on incontinence questionnaire-urinary incontinence short form (ICI-Q-SF) and leakage of urine in 1 h urinal pad test were observed before and after treatment in the patients of the two groups, and the efficacy was compared between the two groups.

RESULTSThe score of ICI-Q-SF and leakage of urine in urinal pad test after treatment were all improved apparently as compared with those before treatment in the two groups (all P<0. 01), and the results in the observation group were better than those in the control group (both P<0. 01). The total effective rate was 86. 7% (39/45) in the observation group, which was better than 68. 9% (31/45, P<0. 05) in the control group.

CONCLUSIONThe transcutaneous acupoint electrical stimulation achieves the better efficacy on FSUI as compared with the oral administration of midodrine hydrochloride tablets. This therapy effectively improves the patient's urine control ability and reduces leakage of urine.

Acupuncture Points ; Adult ; Female ; Humans ; Middle Aged ; Transcutaneous Electric Nerve Stimulation ; Treatment Outcome ; Urinary Incontinence, Stress ; physiopathology ; therapy

Objective To compare the clinical features and treatment between elderly onset rheumatoid arthritis(EORA)and young onset rheumatoid arthritis(YORA).Methods The EORA patients (n=60)and the YORA patients (n =90)were compared regarding sex ratio,activity of pathogenetic condition,disease severity,extra-articular manifestations,complications,laboratory indexes,and therapeutic schedules.Results The female/male ratio was 36/24(1.50 ∶ 1.0)in group EORA,and 69/21(3.3 ∶ 1.0)in group YORA,with higher female/male ratio in in group YORA.The frequency of morning stiffness,proximal interphalangeal joint involvement and metacarpophalangeal joint involvement were lower in group EORA(53.3 ％,46.676％ and 61.67 ％) than in group YORA (72.2 ％,77.8 ％,81.11％) (x2 =5.521,15.385,6.960,P =0.018,0.000,0.008 respectively).Large joints involvement at onset of rheumatoid arthritis was higher in group EORA(38.33 ％)than in group YORA(18.89 ％)(x2=6.960,P=0.008).The joint swollen and tender counts were comparatively less (16.51 ± 7.34) and (15.92 ± 8.44) in group EORA than in group YORA(22.46 ± 7.58) and (23.8 ± 8.93) (t =5.080、5.740,all P =0.000) respectively.The accumulated disease activity score(DAS28)was higher in group EORA(5.86± 1.57)than in YORA(4.92± 1.64) (t=3.360,P =0.001).HAQ score was lower in group EORA(0.83 ± 0.85)than in group YORA (1.16±0.91) (t=2.43,P =0.02).Comorbid conditions such as osteoarthritis,osteoporosis,cardiovascular disease and chronic renal insufficiency were more frequent in group EORA (51.7 ％,31.7 ％,18.3 ％ and 15.00％)than in group YORA(27.8％,15.6％,5.6％ and 4.4％)(x2 =11.722,5.445,6.168,5.067,P=0.001,0.020,0.013,0.024).The positive rate of RF were more higher in YORA(70.00％)than in group EORA (48.33％)(x2 =7.126 P=0.008).The synthetic or biologic traditional DMARDs (disease modifying antirheumatic drugs)were widely used in group YORA(78.9％ and 31.1％)than in group EORA(40.0％ and 10.0％)(x2 =14.940,9.153,P =0.000,0.002).The more frequently used program with glucocorticoids hormonal therapy was received in group EORA(38.3 ％)than in group YORA(20.00 ％)(x2 =6.092 P=0.014) Conclusions EORA patients differs from YORA patients in many of ways,including a more balanced gender distribution,atypical presentation at onset of disease,more frequent involvement of large joints,seronegativity in a higher percentage,and less frequent positivity of anti CCP-antibody,which makes diagnosis more difficult in the earlier period.Therapy of EORA with DMARDs should be instituted based on disease activity,if there is no contraindication.

On the basis of summarizing association rules algorithm and algorithm optimization,the paper explores the rules of prescription compatibility in the scheme for apoplexy diagnosis and treatment through Traditional Chinese Medicine (TCM),establishes the TCM Electronic Medical Records (EMR) database,processes and analyzes the data based on the classical association rule-Apriori algorithm,introduces the parameter optimization mining results of correlated measurement parameters Kulc and IR,eliminates pseudo strong association principle,gets the drug compatibility with strong correlation and theoretical significance,and provides theoretical guidance and reference for apoplexy medication through TCM.

Objective To compare the effect of different sources extracted scutellaria (Hebei, Shanxi and Dalian) on the death-protection and inhibition of FM1 infected mice. Method As animal model, FM1 infected mice was treated an hour after infection. Indexes including mortality, average survival time, lung index were observed to evaluate the effect of different sources extracted scutellaria on anti-influenza virus. Result Different sources extracted scutellaria reduced mortality (P

Objective To study the feature extraction methods for the event related potential (ERP) evoked by mental arithmetical tasks through the sample entropy, in order to enhance the features of electroencephalograph (EEG) signals for brain computer interface (BCI).Methods Three types of mental arithmetic tasks including a simple counting, a random number and a stroke of Chinese character counting were proposed and 16 channel EEG signals were recorded from eight healthy subjects.The sample entropy method was then applied in characteristic signal complexity analysis.The characteristic and difference of signal complexity of ERP evoked by three types of mental arithmetical tasks were explored.Results The entropy value for EEG signal evoked by non-target stimulus was higher than that by the target stimulus with the significant difference (P＜0.01).The entropy of the mental arithmetic based on the Chinese characters counting task was significandy higher than that of the other two tasks (P＜0.05).EEG signals evoked by target/non-target were fundamentally signals under the state of attention or non-attention.Conclusions For the Chinese characters counting task, more complex information have been processed by the brain and the non-linear connection between nerve cells are much more complicated and a higher entropy value is achieved.In summary, the mental arithmetic task can effectively activate the relevant brain regions and the sample entropy can distinguish signals evoked by target or non-target stimuli.

Objective　To study the radiographic findings in the diagnosis of pulmonary lymphoma and pseudolymphoma. Methods　Eight patients with pulmonary lymphoma and 2 with pseudolymphoma were examined by X-ray film, tomography, and CT. Results　Single or multiple nodules or masses were observed in 8 patients with pulmonary lymphoma, shaggy borders or halo of ground-glass attenuation in 7 patients, 2 patients had multiple patchy infiltrates bilaterally, 2 had diffuse interstitial infiltrates and 1 had miliary nodules. Multiple consolidations with air bronchogram and without hilar and mediastinal lymphadenopathy were observed in 2 patients with pulmonary pseudolymphoma. Conclusion　Radiographic findings of pulmonary lymphoma were varied, the most common findings were the nodules or masses with shaggy borders or halo of ground-glass attenuation. The specific findings of pulmonary pseudolymphoma were multiple consolidations with air bronchogram and without hilar and mediastinal lymphadenopathy. The final diagnosis relied on pathology.

Objective To present a new method of osteotomy for malar complex hypertrophy .Methods The operative procedures was transpositional osteoplasty of the malar complex by coronal approach. A lateral orbital osteotomy began at the level of the frontozygomatic suture line,preserving the lateral orbital rim. It continued far down inferoposteriorly across the zygomaticomaxillary suture line. The zygomatic arch was obliquely cut at 1 cm anterior from the articular tubercle. The bone was not separated from the soft tissue to preserve the blood supply to the zygoma and slid upward, inside and setback. The single microplate,screw and steelwire fixation was done on the repositioned zygomatic body.To zygomatic body prominence,it was obtained a satisfactory effect that only shaved the protruded zygomatic body with chisels by means of an intraoral approach.Operative procedures for reductive malar complex plasty were performed in 12 cases. The patients consisted of 3 males and 9 females whose ages ranged from 21 to 36 years.Results Postoperative follow up for 3～24 months showed satisfactory results using this procedure.Conclusion This modified method has an ideal effect without the possibility of bone resorption of the malar complex.

Objective To study the variation of serum IL-1?, Hs-CRP, the monocytes infilitrating into the intima, the expression of HSP-70 in diet-induced hyperlipidemic and chronic Cpn-infected mice and the intervention of berberine. Methods Mice were inoculated intranasally with Cpn three times, every 2 weeks over a 6-week period and fed with high cholesterol diet. C57BL/6J mice were divided randomly into 6 groups:Ber1 group, Ber2 group, azithromycin group, atorvastain group, model group, and normal group. Ber1 group were given berberine at the beginning of Cpn infecting, while Ber2 group, azithromycin group and atorvastain group were given the drug after the 3rd Cpn infecting. The serum index, HE dye of the aortas and immune-histochemistry index were observed. Results The level of serum IL-1?, Hs-CRP, the monocytes infilitrating counting and the expression of HSP-70 in model group were increased. All of the index in Ber group, azithromycin group and atorvastain group declined to some extent. Conclusions Berberine has effect of decreasing inflammatory indexes of diet-induced hyperlipidemic and chronic Cpn-infected mice.

AIM: Supercritical CO_2 extraction of Rhizoma Chuanxiong volatile oil was studied under conditions of extraction temperature between 33-48 ℃,pressure between 10-25 MPa and CO_2 flow rate between 2-4 L?min -1 .Influence of extraction conditions on solubility and mass transfer rate were analyzed. METHODS: Based on plug flow in fixed bed,experimental extraction curves were evaluated using a model put forward by Stastova.And the effects of extraction conditions on mass transfer coefficients were also analyzed. RESULTS: Coefficient of mass transfer was slowly increased as the extraction temperature elevated,and was in accord with flow and in contrast with pressure. CONCLUSION:The method has a practical use value in the extraction of Rhizoma Chuanxiong volatile oil.