Non-receptor tyrosine kinase c-Abl has been implicated in the regulation of the cell cycle,adhesion, apoptosis and DNA damage responses.Its excessive activation is related with the development of chronic myeloid leukemia, and the relationship between c-Abl and leukemia is in depth and detailed research.In contrast to leukemia, the research between c-Abl and solid tumors is just at the early stage.This paper briefly reviews research progress of the c-Abl in solid tumors.

Objective To explore the morphology changes of spinal cord after nursing intervention on motor function repair spinal cord injuried rats. Methods 60 adult SD rats were randomly divided into normal control group, experimental control group, and experimental group ( n=20 for each group) . Each group were divided into four time phase points, that is 1 day, 7 days, 30 days and 60 days after spinal cord injury (n=5). The model of L4 plane with full transection of spinal cord were made in the rats in experimental control group and exper-imental group. Normal control group were of untreated normal rats, experimental control group were given routine nursing such as urination and defecation after spinal cord injury, and experimental group were given passive movement practices and muscle massage training twice a day (10 min each time) besides regular nursing. HE staining and immunohistochemistry method were applied to observe the morphology changes of spinal cord. Results In experimental control group and experimental group there was no significant changes in HE staning and NF-200 and GFAP immunohistchemistry staning in spinal cord section of rat at each time phase points, but compared to the normal control group, it was of significant difference. Conclusion There is no apparent change in morphology in injured spinal area after nursing intervention.

Objective To explore the effect of nursing intervention on degree of motor function recovery after spinal cord injury in rats. Methods 60 rats were randomly divided into three groups with 20 rats in each group. Group A was the control group,group B was the rou-tine nursing group,and group C was the nursing intervention group which was given nursing intervention such as muscle pressure,joint passive movement,and skin care. The ethology was evaluated by BBB score and inclined-plane score at different time points after spinal cord injury. Myoelectricity and wet weight of gastrocnemius muscle were observed at different time points after spinal cord injury through multi-channel physiological signal acquisition system and electronic weighing scales. Results BBB score and inclined-plane score were basically the same. Compared with group B,hind limb function of group C was significantly improved,but it was obviously lower than the control group. Amplitude of gastrocnemius myoelectrical fibrillation in group C was higher than that in group B and gastrocnemius muscle wet weight decrease in group C was lower than that in group B. Conclusion Nursing intervention can delay the speed of gastrocnemius muscle atrophy,improve motor function,and promote the recovery of partial function after the spinal cord injury in rats.

Leptin,the product of the obese gene,is a 16kDa secreted protein produced by white adipocytes.Because of its dual nature as a hormone and cytokine,leptin plays a role in regulating energy metabolism,inflam-marion,immune response,neuroendocrine and angiogenesis,and so on.The review focuses on the research and controversy of leptin's effect in osteoarthritis.

Cholesterol ; metabolism ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Metabolic Diseases ; prevention & control ; Phytotherapy

AIM: To assess the effect of two different suture methods on the degree of pain and corneal epithelium healing condition after pterygium excision combined with autologous conjunctival flap graft transplantation. ·METHODS: Retrospective case-series study. According to the suture method, a total of 92 patients (92 eyes) with pterygium who received treatment in the First Affiliated Hospital of Huzhou University from June 2015 to June 2016 were divided into two group. There were 48 patients ( 48 eyes) in Group A were received intermittent suture, and 44 patients ( 44 eyes ) in Group B were received continuous interlocking suture. The degree of pain after surgery were evaluated between the two groups at 2h, 1d and 1wk after surgery by visual analogue score ( VAS). The healing status of corneal epithelium were observed between the two groups at 1d and 1wk after surgery by fluorescent staining. ·RESULTS: There was no significant difference in the average pain value 2h after surgery between Group A and Group B (P>0. 05). The average pain values 1d and 1wk after surgery in Group B was lower than that in Group A respectively (P<0. 01). Mean scores of corneal epithelium healing condition at 1wk were significantly better in Group B than in Group A (0. 54 ± 0. 32 vs 0. 86 ± 0. 34, P<0. 05), while not significantly different at 1d after the surgery (4. 04±1. 46 vs 4. 30±1. 42, P>0. 05). · CONCLUSION: Compared to intermittent suture, continuous interlocking suture can release pain response after pterygium excision combined with autologous conjunctival flap graft transplantation and promote the healing status of corneal epithelium.

Objective To investigate the effect of informational support on disease uncertainty in liver cancer patients undergoing interventional therapy. Methods Sixty patients of liver cancer patients undergoing interventional therapy were randomly divided into the intervention group and the control group with 30 in each.The control group was treated with general treatment and care. The patients in the intervention group were given general treatment and care with a series of informational support interventions. Patients in the two groups were measured by uncertainty in illness scale (MUIS) at the day of admission,before operations and discharged from hospital. The measurement results were statistically analyzed. Results There was significant decrease about disease uncertainty scores both on the day before operation and the day before discharge in the intervention group compared to the day of admission. The decreasing score of uncertainty in illness in the intervention group was significantly greater than the control group on the day before operation and the day before discharge. Conclusions A series of informational support interventions could significantly reduce the diseases uncertainty in liver cancer patients undergoing interventional therapy.

Objective:Through the cases retrospective study, to analyze the correlation between the adjacent endodontic teeth and the retrograde implantitis. Methods: 32 patients were selected and there were 39 implants (ITI 28,MDIC 11), which adjacent teeth had received endodontic therapy. Record the time from endodontic therapy and the distance of the apex of implants to the adjacent tooth by X-ray photograph. Results: There were 10 implants with retrograde peri-implantitis of 39 implants. In 8 implants, their adjacent teeth received root canal therapy within 3 months(P

Epidermal growth factor receptor (EGFR), an important target for tumor targeted therapy, is overexpressed / mutated in the majority of tumors. Immune cells modified by chimeric antigen receptor , including T cells, NK cells and so on, is a new technology in recent years, which has showed an unique advantage in the treatment of malignant tumors. In this paper, the research progress of T cells and NK cells modified with chimeric antigen targeting for EGFR and its mutants will be reviewed.

Objective To study the radiographic findings of lymphoproliferative disorders of the lung. Methods Twenty five patients with lymphoproliferative disorders of the lung were examined by X ray film, tomography, and CT. Results Multiple and mediastinal lymphadenopathy were observed in 2 patients with pulmonary pseudolymphoma. Multiple nodules or masses were observed in 4 patients with pulmonary lymphomatoid granulomatosis. Hilar and mediastinal lymphadenopathy was observed in each patient with angioimmunoblastic lymphadenophathy, 2 patients had multiple nodules or masses, 8 patients had single or multiple patchy infiltrations, 10 had diffuse interstitial infiltrations. 3 patients with Castlemen′ disease had a mass in the mediastinum, and another patient had mediastinal lymphadenopathy. Conclusion Radiographic findings of lymphoproliferative disorders of the lung are varied, and the final diagnosis relies on pathology.