1.Research progress in applying spectral -domain OCT to explore retinal microstructure changes of diabetic macular edema
International Eye Science 2015;(4):625-629
Diabetic macular edema ( DME ) is a major cause of visual impairment in patients with diabetes mellitus, the central retinal thickness ( CRT ) is correlated with the visual impairment and the changes of visual function before and after treatment. Furthermore, CRT is related to the changes of macular microstructure. The subtle changes of retinal microstructure can be qualitative and quantitative analyzed by spectral- domain OCT ( SD -OCT) . In this study, the changes of retinal microstructure in patients with DME are reviewed, what is of great meaning to explore mechanism, observe disease progress, guide clinical treatment and prospect prognosis of DME.
3.Research progress of chemistry and anti-cancer activities of natural products from Chinese Garcinia plants.
Wen-Wei FU ; Hong-Sheng TAN ; Hong-Xi XU
Acta Pharmaceutica Sinica 2014;49(2):166-174
Garcinia plants are one of the rich sources of natural xanthones and benzophenones which have attracted a great deal of attention from the scientists in the fields of chemistry and pharmacology. Recently, many structurally unique constituents with various bioactivities, especially anti-tumor activity, have been isolated from Garcinia plants. This concise review focused on the anti-cancer activity natural products isolated from Chinese Garcinia plants, and the research finding by authors and collaborators over the past several years were cited.
Antineoplastic Agents, Phytogenic
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chemistry
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isolation & purification
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pharmacology
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Benzophenones
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chemistry
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isolation & purification
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pharmacology
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Cell Line, Tumor
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Cell Proliferation
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drug effects
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Drugs, Chinese Herbal
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chemistry
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isolation & purification
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pharmacology
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Garcinia
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chemistry
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classification
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Plants, Medicinal
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chemistry
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classification
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Structure-Activity Relationship
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Terpenes
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chemistry
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isolation & purification
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pharmacology
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Xanthones
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chemistry
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isolation & purification
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pharmacology
6.CT features of mesenteric lymphadenopathy in active Crohn’s disease
Wen LIU ; Wei WANG ; Longlong XIE ; Yuequn HU ; Sheng LIU
Journal of Practical Radiology 2016;32(4):610-613
Objective To investigate the CT features of mesenteric lymph nodes in patients with active Crohn’s disease.Methods The CT findings in 54 patients with active Crohn's disease proved by histology were analyzed,and the anatomic distribution,size, number,shape and enhancement ratio (ER)of the mesenteric lymph node were assessed.Results Mesenteric lymphadenopathy in 38 patients (70.4%)was found with a total number of 242,83.5%(202/242)of whom were located at the mesenteric root and 16.5%(40/242) at mesenteric edge.The size of the lymph nodes at the mesenteric root was larger than that at the mesenteric edge (8.57 mm±2.26 mm versus 5.38 mm±0.1 9 mm,the mean maximum short diameter),and 73.6% (1 78/242 )of the lymph nodes were oval in shape.The lymph nodes showed significant enhancement after contrast injection with an ER of 0.53 ±0.09.Conclusion Active CD often leads to mesenteric lymphadenopathy,which is more obvious at the mesenteric root.
7.Effect of ACEI on Insulin Sensitivity of Acute Myocardial Infarction Treated with Thrombolytic Therapy
jing, SHENG ; jin-rong, LOU ; wen-wei, CAI
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(11):-
Objective To observe the effect of angiotensin-converting enzyme inhibitor(ACEI) on insulin sensiti-(vity) in dogs with acute myocardial infarction(AMI) after thrombolytic treatment. Methods Twenty dogs were made as AMI models and then underwent thrombolytic treatment.The dogs were divided into the control group(n=10) and the captopril group(n=10) randomly.Insulin,plasma glucose,erythrocyte insulin receptor(EIR),nitrogen(NO) and angiotensin Ⅱ(AT Ⅱ) were(detected) and insulin sensitivity index(ISI) was calculated.The changes of these values in the two groups were contrasted. Results After reperfusion for 120 min,in the control group,ISI and AT Ⅱgot much more rise while EIR and NO fell much more(P
8.Research on the Policy of Standardized Training Program for the Fundamental Medical Practitioners
Sheng-Guo TAN ; Wei-Wen CHEN ; Ji-Na LIAO ; Zhao-Sheng HUANG ;
Chinese Journal of Medical Education Research 2006;0(07):-
It is crucial to improve the health care quality during the progress of constructing the new health care system in both urban and rural area.On the condition of increasing government commonweal investment for the basic health care,the standardized training program for the district medical practitioners will become the pivotal step to improve district health care in urban and rural area,standardize medical service,reduce the medical cost and optimize the accessibility to medical care for the mass.Taking the consideration on the personal resource of district medical service in the urban and rural area in China,certain strategic proposals related to the standardized training program for the fundamental medical practitioners are discussed.
9.Cloning and analysis of STR gene and its promoter from Uncaria
Hao ZHOU ; Xing-xing LU ; Wen-wen AO ; Hai-min LIAO ; Ming-sheng ZHANG ; Wei QIANG
Acta Pharmaceutica Sinica 2022;57(5):1526-1536
On the basis of the
10.Research on Chinese medicine pairs (II)--Their data mining.
Er-Xin SHANG ; Wen-Lin LI ; Liang YE ; Wei ZHOU ; Yu-Ping TANG ; Xin-Sheng FAN
China Journal of Chinese Materia Medica 2013;38(24):4191-4195
Data mining technology has become a powerful tool in traditional Chinese medicine (TCM) research. In this paper, based on the principle and basic requirements of data mining, the mining methods and procedures were described. And then the application of data mining technology in Chinese medicine pair research was classified and summarized, such as the compatibility characters, characteristic pairs, dosage-effect relationship and property compatibility, which provide the direction and data base for modern research of Chinese medicine pair.
Cluster Analysis
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Data Mining
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methods
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Drug Interactions
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Drug Prescriptions
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Medicine, Chinese Traditional
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methods