10.3969/j.issn.2095-4344.2013.25.018

Objective To observe clinical effect of treating chronic obstructive pulmonary disease(COPD) in exacerbation stage with aerosol inhalation of budesonide combined with Chinese herbal enema. Methods 36 cases with COPD were randomly recurited into a control group and a treatment group. The control group was treated with routine western medicine, and the treatment group was treated with aerosol inhalation of budesonide combined with Chinese herbal enema. The clinical effect was observed in both groups, Results The total effective rate in the treatment group and the control group was 88.9% and 72.2%, respectively, showing significant difference between the two group. (P<0.05) .Conclusion The treatment of aerosol inhalation of budesonide combined with Chinese herbal enema on COPD is better than routine western medicine.

Objective To observe the clinical curative effect of SCH 1000 combined with Tanreqing on chronic obstructive pulmonary diseases(COPD). Methods 96 patients with COPD were randomly recruited into a control group and a treatment group. The control group was treated with SCH 1000 aerosol and the treatment group was treated with SCH 1000 aerosol combined with Tanreqing injection. Results The treatment group had better clinical curative effects than the control group, with (P<0.05) .Conclusion The treatment of SCH 1000 combined with Tanreqing on COPD is effective.

Objective To observe the effects of treating pulmonary infection of the aged people with the combination of TCM and WM.Methods A total of 120 the aged patients with pulmonary infection were randomly recruited into a control group and a treatment group,60 patients in each.The control group was treated with cefoperazone,sulbactam intravenously drop and inhalation of low flow oxygen(1～2L/min,2～4h,once/day),while the treatment group was added modified Xiaocaihu decoction and Shengmai injection on the basis of the control group.Both groups were treated for 14 days.Results The significant effective rate was 63.3%and 45.0%in the treatment group and the control group respectively,showing significant difference(U=0.5248,P<0.01).The effective rate was 96.7%and 83.3%in the treatment group and the control group respectively,also showing significant difference(U=0.5314,P<0.05).Conclusion It is effective to treat pulmonary infection of the aged patients with modified Xiaocaihu decoction and Shengmai decoction together with western medicine.

Objective To study the clinical effect ofprednisone combined with Shuxuening injection on pulmonary interstitial fibrosis. Methods 120 cases were randomly recruited into a treatment group and a control group. The control group was treated with prednisone, and the treatment group was additionally given Shuxuening injection on the basis of the control group. The changes of vital capacity (VC), PO_2, PCO_2 and imaging were observed. Results The total effective rate was 81.67% and 66.67% in the treatment group and the control group Respectively, showing significant difference (P<0.05). VC and PO_2 were raised in both groups after the treatment (P<0.05), while the treatment group showed better results than the control group (P<0.05). PCO2 were also raised in both groups after the treatment (P<0.05), while there was no significant diference between the two groups (P > 0.05). There were 27 cases (45.00%) and 19 cases (31.67%) showed improvement in imaging in the treatment group and the control group respectively, manifesting a significant difference (P<0.05) . Conclusion Treatment of prednisone with Shuxuening injection is better than prednisone on pulmonary interstitial fibrosis. This method is worthy of clinic promotion.

Objective To observe attenuation and synergy of postoperative chemotherapy combined with Tianzhicao capsule in patients who suffered from breast cancer. Methods 66 cases after radical mastectomy were randomly divided into treatment group 31 cases and 35 cases of control group. The patients of control group were treated with chemotherapies of CAF and TA. Treatment group patients were given Tianzhical capsule orally at the same time. Nausea and vomitting,the arrest of bone marrow before and after treatment were observed. The grade of life quality about every patient was evaluated. Results Myelosuppression and the occurrence of nausea and vomitting in treatment group was obviously lower than control group (P ＜ 0.05). The proportion of improvement and stabilization for the quality of life in treatment group was markedly higher than control group (P ＜ 0.05). Conclusion Traditional Chinese drug Tianzhicao capsule had attenuation and synergy to postoperative chemotherapy in breast cancer.

Objective To observe the curative effects of Jawei-Wendan decoction in treating acute exacerbation of COPD due to phlegm blocking in lung. Methods From July 2010 to June 2013, 66 enrolled cases were randomly divided into a treatment group and a control group with 33 in each. Aside from receiving anti-infection and symptomatic treatment as the control group did, the treatment group was also given orally Jawei-Wendan decoction. The symptoms, pulmonary function and the variety of the laboratory indexing were observed before and after the treatment. Results ①The treatment group attained better curative effects(P<0.05) and got shorter symptomatic relief time of cough, expectoration and breathless(The T-value is respectively 16.770, 8.635, 16.762, P<0.05). ②After 7-days treatment, the cure rate of the treatment group was 63.64%, and the control group was 39.39%. Their difference was conspicuous(P<0.05). The total effective rate in treatment group was 96.97%, which was 90.91% in control group. Their difference was inconspicuous(P>0.05).③The pulmonary function indices increased significantly in the treatment group[The values of FEV1、FVC and FEV1/FVC% are (1.41±0.46)L, (2.18±0.63)L and (66.41±6.33)% before treatment, which were (2.21± 0.55)L, (2.83±0.53)L and (77.37±7.64)%after treatment, P<0.01]. A comparison of the two groups showed significant differences regarding the pulmonary function indices(P<0.05). Conclusion Jawei-Wendan decoction had good curative effect in treating acute exacerbation of COPD due to phlegm blocking in lung.

OBJECTIVETo study the effect of Compound Ezhu Powder (CEP) on serum levels of CA125 and CA19-9, and the expression of cyclin D protein in endometriosis patients, thus providing theoretical evidence for clinical application of CEP.

METHODSTotally 69 all endometriosis patients underwent surgical treatment at Department of Gynecology and Obstetrics, Tianjin Nankai Hospital from January 2011 to January 2013 were randomly assigned to group A (35 cases) and group B (34 cases). Meanwhile, 30 patients with uterine fibroids who prepared for surgical treatment during the same period were recruited as the control group. Patients in group A took EZP 3 months before surgery. No treatment was given to patients in group B and the control group. The serum CA125 level and the expression of cyclin D in the ectopic endometrium and the eutopic endometrium were detected in the 3 groups before surgery.

RESULTSThe expression of cyclin D was higher in group A and group B than in the control group (P < 0.05). The serum levels of CA125 and CA19-9 were significantly lower in group A than in group B (P < 0.05). The expression of cyclin D in the ectopic endometrium was lower in group A than in group B, but with no statistical difference (P > 0.05). The expression of cyclin D in the eutopic endometrium was significantly lower in group A than in group B with statistical difference (P < 0.05). Meanwhile, the serum CA125 level was positively correlated with the serum CA19-9 level (r = 0.45, P < 0.05).

CONCLUSIONSThe expression of cyclin D obviously increased in endometriosis patients, which was associated with the occurrence of endometriosis. CEP could lower serum levels of CA125 and CA19-9, and down-regulate the expression level of cyclin D, indicating its roles in inhibiting the cell cycle.

Adult ; Antigens, Tumor-Associated, Carbohydrate ; blood ; CA-125 Antigen ; blood ; CA-19-9 Antigen ; blood ; Cyclin D1 ; metabolism ; Drugs, Chinese Herbal ; pharmacology ; Endometriosis ; blood ; drug therapy ; Female ; Humans

2.0 mmol/L(44.83?14.13,45.95?13.21,allP