Objective To explore the effect of vitamin Bl2 with JUC on skin protection in cervical cancer patients with radiation therapy.Methods A total of 60 patients who had radiodermatitis of degree Ⅱ and above were randomly divided into two groups:the treatment group and the control group,each with 30 patients.Patients in treatment group were treated with vitamin B12 combined with JUC,while patients in control group were treated with routine skin protection measures.Healing of skin damage was observed and compared between two groups.Results Skin repair in treatment group was more obvious than that in control group and radiation therapy was not interrupted.The total effective rate,degradation rate and stability rate were respectively l00％,83.3％ and 16.7％ in treatment group,and 73.3 ％,33.3％ and 40％ in control group,and the differences were statistically significant (x2 =4.00,P ＜ 0.05).Conclusions Vitamin B12 combined with JUC has good effect on radiodermatitis,as well as has advantages of little adverse reaction and convenience,thus is worthy promoting.