1.Pulmonary sequestration: a literature review of 2625 cases
Chinese Journal of General Practitioners 2010;09(10):714-715
Total 2625 cases of pulmonary sequestration were collected from literatures of Chinese National Knowledge Infrastructure from 1998 to 2008. The age, gender, clinical symptoms, chest CT scan,chest X-ray findings, lesion location, supplying artery, venous reflux, and preoperative misdiagnosis of 2625 cases were retrospectively reviewed. The male: female ratio of all cases was 1.58: 1. The main clinical symptoms of pulmonary sequestration were cough, sputum, fever, hemoptysis and chest pain, but 13.36% patients were asymptomatic. Chest CT scan showed pulmonary massive lesions (49.00%), pulmonary cystic lesions (28.57%), pulmonary cystic-solid lesions ( 11.57% ), and flaky shadows (7.96%). Pulmonary sequestration mainly located in the lower lobe; 66. 43% located in the left posterior basal segments, and 20. 16% located in the right posterior basal segments. Pulmonary sequestrations were divided into three types, intralobar sequestration (83. 84% ), extralobar sequestration ( 16.03% ), and mixed sequestration (0.13% ). The arterial supply was mainly from branches of thoracic aorta (76. 55% ) and abdominal aorta (18.47%). The clinical manifestations of pulmonary sequestration were various, so the preoperative misdiagnosis rate was as high as (59 ± 20) %. We should take full advantage of clinical symptoms, imaging findings and location characteristics to improve the preoperative diagnosis rate.
2.How we diagnose and treat chronic lymphocytic leukemia.
Chinese Journal of Hematology 2018;39(7):529-532
4.Advances in study of dioscin--a natural product.
Li-Na XU ; Yong-Li WEI ; Jin-Yong PENG
China Journal of Chinese Materia Medica 2015;40(1):36-41
Dioscin, a typical saponin, is widely present in the family of Dioscoreaceae, Liliaceae, Caryophyllaceae and Rosaceae, especially in Dioscoreaceae, including Discorea nipponica Makino, Dioscorea zingiberensis C. H. Wright and Dioscorea panthaica Prain et Burkill. Traditional Chinese medicine reported that dioscin plays a role in expectorant, relaxing the muscles and stimulating the blood circulation, aiding digestion and diuresis. With the development of science and technology in recent years, some new extraction and separation techniques and methods have been applied to the study of dioscin, and more and more pharmacological effects were found. Modern pharmacology studies have confirmed that dioscin had some activities on desensitization, anti-inflammatory, lipid-lowering, anti-tumor, hepatoprotection and anti-viral. After oral administration, dioscin is metabolized to diosgenin, which is the true active ingredient and is an important raw material to synthesize steroid hormone drugs. Therefore, the studies on dioscin are valueable and promising. In this review, we make a summary on the researches of dioscin including the extraction technology, separation and prepara- tion, chemical synthesis, drug metabolism, determination and pharmacological researches.
Animals
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Biological Products
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adverse effects
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chemistry
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pharmacology
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Diosgenin
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adverse effects
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analogs & derivatives
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chemistry
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pharmacology
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Humans
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Plant Extracts
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adverse effects
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chemistry
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pharmacology
5.Protective effects and mechanism of activin in neonatal rats with hypoxic ischemic brain damage.
Li AN ; Wei-wei ZHU ; Ping WANG ; Yong-li CAO
Chinese Journal of Pediatrics 2005;43(6):465-466
Activins
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administration & dosage
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pharmacology
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Animals
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Animals, Newborn
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Apoptosis
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drug effects
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Cerebral Cortex
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drug effects
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pathology
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ultrastructure
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Female
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Hippocampus
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pathology
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ultrastructure
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Hypoxia-Ischemia, Brain
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drug therapy
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pathology
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Injections, Intraperitoneal
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Male
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Microscopy, Electron
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Neuroprotective Agents
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administration & dosage
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pharmacology
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Rats
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Rats, Wistar
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Treatment Outcome
6.Clinical analysis of chronic cough caused by postnasal drip syndrome.
Yong-Dong YAN ; Li HUANG ; Wei JI
Chinese Journal of Contemporary Pediatrics 2008;10(1):79-80
Adolescent
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Child
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Child, Preschool
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Chronic Disease
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Cough
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etiology
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Female
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Humans
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Male
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Rhinitis
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complications
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diagnosis
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drug therapy
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Sinusitis
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complications
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diagnosis
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drug therapy
7.Study on effect of Xiaoaiping in enhancing efficacy of neoadjuvant chemotherapy for breast cancer and its mechanism.
China Journal of Chinese Materia Medica 2015;40(4):749-752
Traditional Chinese medicine (TCM) Xiaoaiping shows a pharmacological activity in treatment of breast cancer. Although neoadjuvant chemotherapy has been more and more widely used in treatment of breast cancer in recent years, no report has been made about the clinical efficacy and mechanism of the combined application of neoadjuvant chemotherapy and Xiaoaiping in treatment of breast cancer. In this study, 66 patients with breast cancer were selected and divided into the control group and the treatment group evenly with the random number table method. All patients received TEC neoadjuvant chemotherapy. On that basis, the treatment group also received the adjuvant therapy of Xiaoaiping injection (60 mL, i. v. , qd). The short-term response rate and the follow-up survival rate of the two groups were observed and compared. Surgical specimens of the patient were collected to observe and compare their expressions of estrogen receptor ER-α36 in breast cancer tissues with the immunohistochemical method. According to the findings, the overall response rate of the treatment group was 78.79%, which was significantly higher than that of the control group (57.58% , χ2 = 5.48, P < 0.05). Compared with the control group, the treatment group showed significant increases in the disease-free survival (DFS) rate and the total survival rate at the 3rd year and 5th year (all P < 0.05) , and a notable reduction in ER-α36 expression in breast cancer tissues (P < 0.05). Based on the our results, Xiaoaiping can significantly enhance short-term ad long-term efficacies of neoadjuvant chemotherapy for breast cancer. Its mechanism may be correlated with the inhibition of ER-α 36 expression in breast cancer tissues.
Adult
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Aged
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Antineoplastic Agents
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administration & dosage
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Breast Neoplasms
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drug therapy
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genetics
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metabolism
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mortality
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Combined Modality Therapy
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Drug Therapy, Combination
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Drugs, Chinese Herbal
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administration & dosage
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Estrogen Receptor alpha
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genetics
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metabolism
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Female
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Humans
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Middle Aged
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Neoadjuvant Therapy
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Treatment Outcome
10.Simultaneous Determination of Chlorogenic Acid and Cefazolin in Rat Plasma With HPLC
Ping WEI ; Jianhuai LI ; Yong ZHAO
China Pharmacy 2001;12(4):208-209
OBJECTIVE:To establish a HPLC method for simultaneous determination of chlorogenic acid and cefazolin in rat plasma.METHODS: Chromatographic determination was performed on spherisorb C18 column with methyl alcohol- 0. 1mol/L potassium ethydrogen phosphate(30: 70v/v, pH 3.0)as the mobile phase and a flow rate of 1.2ml/min.Detection wavelengthes were UV 275nm for chlorogenic acid and 326nm for cefazolin.The concentrations of chlorogenic acid and cefazolin in rat plasma were detected.RESULTS: The calibration curves were linear with the correlation coefficients of 0.997 and 0.998, repectively.The RSDs for the between- day and within- day were both lower than 4% for chlorogenic acid and 6% for cefazolin, respective.The mean recoveries were 93.30%, 93.35% and 96.40% for chlorogenic acid, and 93.41%, 96.60% and 92.36% for cefazolin at large, middle and low dosages, respectively.The concentrations of cefazolin in rat plasma were decreased in coadministration with chlorogenic acid.CONCLUSION: The study provides a simple method for simultaneous determination of the plasma levels of chlorogenic acid and cefazolin.