Objective To investigate the seroprevalence of hepatitis D virus in Foshan of Guangdong province,to provide the data for the study about it in China.Methods ELISA kits from two different companies were used for detecting anti-HDV IgG of all the serum samples,and then RT-PCR was carried out about the selected serum to ensure the results.All the serum samples were collected in 2011 in The First People's Hospital of Foshan.Results The results from two ELISA kits and RT-PCR were identical.Eight samples were positive.Conclusions The seroprevalence rate of HDV in Foshan is higher than that in China.It has no statistically significant difference between female and male.Morever,the older with HBsAg are susceptible to HDV.