OBJECTIVE:To investigate the effect of compound glycyrrhizin(SNMC)combining artificial liver on severe hepatitis.METHODS:58patients with severe hepatitis were randomly divided into two groups,for the control group,apart from the basic treatment,each of them was also given plasmapheresis or hemoperfusion every3d～5d for5～10times ac?cording to their state of illness;For the treatment group,they were treated with SNMC apart from the therapy of the control group.RESULTS:The total effective rates of the treatment group and the control group were64.52%and40.74%,respec?tively,thus significant differences existed between the2groups(P

Despite the continued development of radiotherapy and chemotherapy,surgery is still the first choice for the treatment of colorectal cancer.Complete mesocolic excision (CME) based on anatomy and embryology,the sharp separation is carried out along the embryonic development.A large number of clinical trials have confirmed that the operation can significantly reduce the local recurrence rate and improve survival rate.The technique may become a standardized surgery for colon cancer.To learn about the research progress of the application of complete mesocolic excision,this paper collected relevant literatures of CME for reviewing.

Objective To explore the prognostic value of long-time EEG monitoring and the clinical examination index in comatose patients.Methods The long-time EEG monitoring and the modified Glasgow coma scale were done in 26 comatose patients(15 patients were male;11 patients were female;17—40 years old)in acute phase.The complexity of cerebral hemisphere was analyzed by computer.The patients were followed-up for 2 months and evaluated by Glasgow outcome scale.The correlation between the long-time EEG monitoring,clinical examination index and the prognosis of the patients was analyzed.The time- variation of hemisphere complexity and the relationship between prognosis and entropy were observed. Results The specificity(77.8%)and accuracy rate(92.3%)of long-time EEG monitoring in predicting the outcome of the acute comatose patients were higher than those of clinical examination.The EEG index appeared more closed-up with prognosis than clinical examination.The correlation coefficient between the EEG index and the modified Glasgow prognosis scoring was r=0.81(P

Objective To observe the effect of facilitation techniques of breathing combined with acupuncture on post-stroke hiccup.Methods 68 post-stroke hiccup patients were divided into 2 groups, 34 cases in each group. The observation group was treated with the facilitation techniques of breathing combined with acupuncture, while the control group was treated with acupuncture only. The two groups were evaluated on the 3rd and 7th day after treatment. Results The total efficacy was higher in the observation group than in the control group (P<0.05). Conclusion Facilitation techniques of breathing may release the post-stroke hiccup.

Objective To statistically analyze clinical research literature on acupuncture treatment of gouty arthritis, explore regularities in its point selection and provide a basis for clinical point selection and reasonable point combination.Method Gouty arthritis, acupuncture, warm needling moxibustion, electroacupuncrue and fire needling were used as key words. January 1990 to May 2014 China HowNet (CNKI) full-text database and Wanfang academic periodical full-text database were searched to retrieve, sort out and analyze clinical literature on acupuncture treatment of gouty arthritis at home and abroad. Acupoints included in the literature were sorted out. Statistical analysis was made of the categories, meridians, use frequencies and positions of selected acupoints.Result One hundred and thirty-five articles with a total of 120 acupoints were included. From the analysis of point selection, the acupoints most frequently used to treat gouty arthritis were, arranged in order, Taichong (91), Sanyinjiao (87), Zusanli (80), Yinlingquan (58), Quchi (52), Taixi (51), Yanglingquan (45), Xuehai (44), Taibai (44) and Hegu (44). From the analysis of pertaining meridians, the meridians of more frequently used acupoints were the spleen meridian of foot-taiyin (323), the stomach meridian of foot-yangming (209), the large intestine of hand-yangming (143), the liver meridian of foot-jueyin (140), the gallbladder meridian of foot-shaoyang (134), the kidney meridian of foot-shaoyin (84) and the bladder meridian of foot-taiyang (80). From the analysis of point selection from different places, the part where acupoints were most distributed was the lower limb.Conclusion For acupuncture treatment of gouty arthritis, local and along-meridian point selections are main ones, selected points are relatively scattered and often located in the lower limb, and point selection is partly combined with syndrome differentiation, which provide a clinical reference.

Adenocarcinoma ; diagnosis ; therapy ; Guidelines as Topic ; Humans ; Thyroid Neoplasms ; diagnosis ; therapy

Objective To evaluate the diagnostic value of computer-aided diagnosis with three-dimensional volumetric measurement in solid pulmonary nodules on follow-up CT. Methods Forty-six patients with 58 solid nodules were evaluated.Each patient underwent chest CT at least twice.The volume, doubling times(DTs) and volumetric growth rates(VGRs) of nodules were calculated with three-dimensional volumetric measurement software. If there were significant statistical differences in DTs between malignant and benign nodules, Nonparametric test was used to make the analysis.If there were significant statistical differences in upper DTs'values between malignant and benign nodules, X2 test was used to make the analysis.Final diagnosis of all nodule were confirmed by pathology or by response to diagnostic therapy or by clinical follow-up.Results The DTs of 13 malignant nodules were <400 days in 12 nodules, with a range from 45 to 465 days (median, 159 days) ; the VGRs ranged from 8% to 329% (median, 30.0%).The VGRs of 45 benign nodules ranged from -38% to 24% (median, 0%).The DTs of 24 benign nodules that increased or not changed in size were >400 days in 22 nodules, with a range from 302 days to 55 158 days (median, 2 704 days); the VGRs ranged from 0 to 24% (median, 6.5%. Twenty-one nodules that decreased in size had the VGRs ranging from -38% to -4% (median, - 16.0%), and the DTs of these nodules could not be calculated by software.There were significant statistical differences in DTs between malignant and benign nodules(P <0.05).Taking 500 days, 400 days and 300 days as the upper value for malignancies there were statistically significant differences in these values between malignant and benign nodules(P < 0.01).Their sensitivities were 100.0%, 92.3%, 76.9% respectively and specificities were 87.5%, 91.7%, 100.0% respectively.Accuracies were 91.9%, 94.6% ,91.9% respectively and positive predictive values were 8,11,0.Conclusions Taking 400 days as the upper DTs'value for malignancies has important diagnostic value. Computer-aided diagnosis with three-dimensional volumetric measurement is sensitive to the volume changes of solid pulmonary nodules on follow-up CT, and is useful in the differential diagnosis of pulmonary nodules.

Objective To investigate the effect of life style combined with dietary intervention on non-alcoholic fatty liver disease(NAFLD).Method One hundred and twenty five subjects of NAFLD with overweight and obesity,aged 30-60 years,were enrolled in the study from the group for physical examination in Health Administration Center of our hospital during 2006-2007.They were diagnosed to be 48 mild,70 moderate and 7 severe cases by ultrasonic tomography.A regime of dietary intervention combined with exercise was planned according to 3 d dietary survey before intervention.They were asked to follow the therapeutic menus and exercise instruction during 12 mon of the study.We followed up the subjects and gave them instructions regularly in the whole period of study.Results After 12 mon interven-tion,the body weight(BW),body mass index(BMI),waist-hip ratio(WHR),serum total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C) and alanine glutamate aminotransferase(ALT) of the subjects were decreased significantly.High density lipoprotein cholesterol(HDL-C) was not changed.By ultrasonic tomography,16% of the subjects recovered to normal,and 77 moderate to severe cases deceased to 31,with reduction rate 59.7%.Conclusion Good therapeutic effects were observed after 12 mon of dietary intervention combined with rational exercise.

Objective To study the rule with the treatment based on the pattern differentiation of systemic lupus erythematosus, by analyzing the literature of traditional Chinese medicine for the treatment of systemic lupus erythematosus from January 1999 to July 2014 included in China National Knowledge Infrastructure(CNKI) and summarizing the frequency of TCM pattern and medicine.Methods The frequency statistics and classified analysis were used to describe the patterns and medicines.Results There were 14 patterns, the common patterns are pyretic toxicity with 23(15.13%), deficiency of both qi and yin with 21(13.82%), qi and blood stasis with 20(13.16%). The disease was involved with liver, spleen and kidney. Pattern factors were mainly sthenia factors, accounting for 65.30% of the total, including hot, blood stasis, toxin, damp-heat, qi stagnation, phlegm; asthenia factors were accounted for 34.70% of the total, including deficiency of yin, deficiency of qi, deficiency of yang and deficiency of blood. There were 201 medicines included, the total frequency was 1 669, which could be into 17 categories. The top three were heat-clearing, tonic and stasis-dissolving medicines. Medicine tropisms are mainly lung tropism, stomach tropism, liver tropism, heart tropism, spleen tropism and kidney tropism, accounting for 88.12% of the total.Conclusions Pyretic toxicity is responsible for the sthenia factors of systemic lupus erythematosus, and deficiency of qi and yin is the main responsibility for asthenia factors, treatment should pay attention to both sthenia and asthenia factors.

After a description of research contents and methods in scientific literature novelty assessment and tech-nical competitive intelligence , the necessity and feasibility to add technical competitive intelligence analysis into scientific literature novelty assessment were analyzed , followed by an elaboration on adding technical competitive in-telligence analysis into scientific literature novelty assessment in aspects of the contents , types and report of scientific literature novelty assessment in combination with case analysis , which showed that technical competitive intelligence analysis is an effective method for searching literature and writing scientific literature novelty assessment report .