Objective To observe the effectiveness and salty of Xiaoer Dingfeng Decoction(Decoction to stop wind in children con- vulsion)in the treatment of syndrome of primary infantile convulsion due to phlegm-heat in tonic-clonic epilepsy.Methods Totally 90 infantile patients were randomized into three groups,which were treated by Xiaoer Dingfeng Decoction,Kangxian(Capsule to treat epilepsy)and Xifeng Capsule(Capsule to calm the wind)respectively.Frequency of seizure,lasting duration,and change of electroen- cephalogram(EEG)were observed 12 months later.Results The total effective rate of Xiaoer Dingfeng Decoction group was 86. 67%,better that that of Kangxian Capsule group(P0.05). It could greatly reduce the frequency of seizure,shorten the lasting duration,and improve the EEG.Conclusion Xiaoer Dingfeng De- coctions is effective and safe for the syndrome of primary infantile convulsion due to phlegm-heat in tonic-clonic epilepsy.

0.05). The expression of IL－ 1, IL－ 6, TNF－? in fibromatosis and the periosteum of CPT was higher than that in normal periosteum and traumatic pseudarthrosis (P

As the application of e-medical record in clinical practice,patients' privacy has been challenged due to the unsafe factors in programming system,administration and usage of records,and data share of network,etc.The paper comes up some countermeasures to protect patients' privacy including refining technological specification of the formation,storage,and utilization of e-medical records,reducing program flaws and hidden dangers,and enhancing e-medical record users' legal consciousness and patients' consciousness of self-protection,in order to protect the patients' privacy and promote the healthy development of e-medical record.

Objective To study the cognitive tendencies in recognizing negative emotional faces.Methods The experiment used the traditional flanker paradigm for reference.Forty-eight university students (19 males,29 females) finished the flanker tasks deigned by E-Prime, and their accuracy rate and reaction time were recorded in the study.Results ANOVA revealed that,in all cases,the accuracy rate of anger was significant higher than fear and sadness (96.60% ,94.50% ,94.40% ) (P＜0.05).And when the flanking stimuli were fear faces or there were no flanking stimuli, the reaction time of anger was much shorter than fear and sadness ( respectively,fear(801.27 ± 140.99) ms,anger(723.94 ± 151.37 ) ms, sadness(812.21 ± 148.85 ) ms; fear(788.17 ±148.81 ) ms, anger ( 694.28 ± 111.99 ) ms, sadness (763.57 ± 133.91 ) ms, P ＜ 0.05 ).When the flanking stimuli were anger or sadness faces, the reaction time of anger was significant shorter than fear( respectively, fear( 824.09 ± 164.42) ms, anger (721.48 ± 124.06 ) ms, sadness ( 760.50 ± 131.12 ) ms; fear ( 798.95 ± 146.40) ms, anger (702.55 ± 136.07 ) ms, sadness (750.48 ± 133.86) ms, P ＜ 0.05).Conclusion There are no flanker effects in recognizing different negative emotional faces, but there are anger superiority effects of face recognition and cognitive tendencies, which is helpful for clinical diagnosis and treatment of some diseases associated with emotional disorders.

OBJECTIVETo study the correlation between lacunar cerebral infarction and level of serum uric acid in elderly male hypertension patients.

METHODSNinety-eight elderly male hypertension patients were enrolled in this study. They all underwent cerebral magnetic resonance imaging (MRI) scan, and their clinical and laboratory data were collected. The patients were divided into the 1st group (n = 32), the 2nd group (n = 32) and the 3rd group (n = 34) according to the level of serum uric acid.

RESULTSThe numbers of lacuner infarction, serum creatinine, urea and high density lipoprotein(HDL) were significantly diferrent from the other groups. The numbers of lacuner infarction were positively related with serum uric acid and urea. Multiple variant analysis showed that serum uric acid was the independent factor of the numbers of lacuner infarction.

CONCLUSIONThe elevated level of serum uric acid may contribute to the risk factors of lacuner infarction.

Aged, 80 and over ; Cerebral Infarction ; etiology ; Humans ; Hypertension ; blood ; complications ; Male ; Regression Analysis ; Risk Factors ; Uric Acid ; blood

Aims Tocomparethepharmacokineticsof ephedra alkaloids,cinnamic acid and cinnamic alcohol in Ephedrae, Cinnamomi and Ephedrae-Cinnamomi herb couple through UPLC-MS/MS in rats respective-ly,and to investigate the effect of combination on phys-iologicaldisposition.Methods Plasmasampleswere collected at different times after oral administration of Ephedrae,Cinnamomi and Ephedrae-Cinnamomi herb couple extracts.The concentrations of ephedra alka-loids,cinnamic acid and cinnamic alcohol in plasma samples were determined by UPLC-MS/MS.DAS 3. 0 was used to calculate pharmacokinetic parameters.The differences of samples in two groups were conducted with univariate statistical analysis using SPSS 13. 0. Results ComparedwithEphedraegroup,theCmaxof norephedrine hydrochloride, norpseudoephedrine hydrochloride,ephedrine hydrochloride,pseudoephed-rine hydrochloride,and methylephedrine hydrochloride in Ephedrae-Cinnamomi herb couple group were signif-icantly greater (P<0. 05 );the AUC0-t of norpseudo-ephedrine hydrochloride was significantly greater (P<0. 05 );the MRT0-t of norephedrine hydrochloride, phedrine hydrochloride, pseudoephedrine hydrochlo-ride,and methylephedrine hydrochloride were signifi-cantly less (P <0. 05 );the T1/2z of norephedrine hydrochloride,phedrine hydrochloride,and methyl-ephedrine hydrochloride were significantly less (P <0. 05 ).The AUC0-t and MRT0-t of cinnamic acid and cinnamic alcohol were significantly greater than those inCinnamomigroup(P<0.05).Conclusion The combination of Ephedrae and Cinnamomi improves the absorption concentration of five ephedra alkaloids, Slows down the elimination of norephedrine hydrochlo-ride,phedrine hydrochloride,pseudoephedrine hydro-chloride,and methylephedrine hydrochloride,and in-creases the bioavailability of cinnamic acid and cin-namic alcohol.

Objective To observe the clinical efficacy of acupuncture plus contralateral needling in treating post-stoke myodystonia. Method Totally 120 patients with post-stroke myodystonia were randomized into group A, B, C and D, 30 in each group. Group A was intervened by yin-reducing and yang-tonifying needling method plus contralateral needling; group B was by ordinary acupuncture plus contralateral needling, group C was by yin-reducing and yang-tonifying needling alone, while group D by ordinary acupuncture. Clinical Spasticity Index (CSI) was observed before and after intervention. Result After treatment, the CSI scores (tendon reflex, muscle tension, episodic spasm scores and total score) were significantly changed in the four groups (P<0.01, P<0.05). The tendon reflex score, muscle tension score and total score in group A were significantly different from that in the other three groups after intervention (P<0.01,P<0.05). There was a significant difference in comparing the episodic spasm score between group A and D after intervention (P<0.01). There were significant differences in comparing the tendon reflex score, muscle tension score and total score between group B and D after intervention (P<0.05). The total score in group C was markedly different from that in group D after intervention (P<0.05). Conclusion Yin-reducing and yang-tonifying needling method plus contralateral needling is an effective method in treating post-stroke myodystonia.

Objective To discuss the clinical application value of ultrasound contrast on evaluating fallopian tube patency.Methods Ultrasound contrast examination was conducted on 84 patients suffering from infertility and the flowing status of contrast agent in the uterine cavity and the fallopian tube and the distribution condition in the pelvic cavity were observed under the real -time ultrasound to judge the patency condition of the fallopian tube.Results After 84 patients receiving ultrasound contrast,38 cases'bilateral fallopian tubes were unobstructed,26 cases'lateral fallopian tube were unobstructed and 20 cases'bilateral fallopian were obstructed.Comparing the result of ultrasound contrast with laparoscopy,the diagnosis accuracy was 89.5%,the specificity 86% and the sensitivity 94%.Conclusion Fallopian tube ultrasound contrast technique can make an accurate and objective evaluation on the fallopian tube patency,it is an effective method to check fallopian tube patency and it is of high clinical application value.

The microbial transformation of buflomedil by Cunninghamella blakesleana AS 3.153 was studied, as well as a microbial model which can be used to mimic metabolism of buflomedil in mammal was established. Experiments were conducted to screen the capabilities of four strains of Cunninghamella species to transform buflomedil, in which C. blakesleana AS 3.153 was selected for a preparative biotransformation. Furthermore, the microbial model was established based on the transformation condition optimization. The parent drug and its metabolites produced by C. blakesleana AS 3.153 were detected by liquid chromatography-mass spectrometry method and three metabolites were identified while two of them were new found metabolites. Two major metabolites, para-O-desmethyl buflomedil and 12-C-oxidated buflomedil, were isolated by semi-preparative HPLC. Based on the comparison between different species, the microbial transformation of buflomedil by C. blakesleana AS 3.153 is more similar to the metabolism of buflomedil in human and Beagle dog than that in rat.

BACKGROUND:The incidence of complications folowing conventional repairing for the ruptured tendon is up to 73%, such as delayed healing, adhesion, secondary rupture. These complications severely affect ankle joint function of the patients. OBJECTIVE:To reduce the complications folowing the repair and investigate the role of hernia repair materials in the repairing of ruptured Achiles tendon. METHODS:Eleven patients who underwent repair of ruptured Achiles tendon were retrospectively studied. Among them there were eight males and three females with the mean age of 42 years (26-58 years). Three cases were injured in left side and eight cases were in right side; four cases were open injury by sickle-induced damage and seven cases were closed injury by exercise-induced damage. The hernia repair materials after pruning was applied with a “wrap” method to strengthen the anastomosis repair of Achiles tendon after the conventional repair surgery had been completed. At the time of folow-up, al patients were observed for postoperative local appearance and function recovery, and assessed with Arner Lindholm standards. RESULTS AND CONCLUSION:The folow-up interval was 6-45 months (average 24.5 months). Two cases were lost to folow-up. According to the Arner Lindholm standards, the effects were excelent in seven cases (78%) and good in two cases (22%). Local appearance and function recovered wel postoperatively, and no complications occurred such as wound infection, secondary rupture and so on. A “wrap” method with hernia repair materials is suggested to strengthen the anastomosis repair of ruptured Achiles tendon after the conventional repair surgery is completed, it can significantly promote the healing of Achiles tendon ruptured end anastomosis, prevent Achiles tendon recurrent ruptures, local adhesion and infection.