Objective To find out the clinical effects of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding.Methods 87 patients with perimenopausal dysfunctional uterine bleeding were received mifepristone treatment.The thickness of the endometrium and sex hormones indicators,including progesterone(P),estrogen (E2),the corpus luteum generated hormone (LH),follicle hormone (FSH),prolactin (PRL) and testosterone (T),were checked before and after treatment.Results The treatment efficiency was 90.8％.Endometrial thickness before treatment (10.9 ± 1.9) mm,endometrial thickness after treatment (5.4 ± 1.1) mm,with significant differences between them(t =0.684,P ＜ 0.01).After treatment,patients with hemoglobin (102.5 ± 7.1) g/L,significantly increased compared with before treatment (t =0.539,P ＜ 0.01).After treatment,the P,E2,LH,FSH levels were significantly lower than those of before treatment (t =0.690,0.552,0.513,0.376,all P ＜ 0.05) ; PRL,T levels after treatment compared with before treatment,there were no significant differences (all P ＞ 0.05).Conclusion The mifepristone treatment for perimenopausal uterine bleeding has high effective rate,less adverse reactions,and high clinical value.

Nonarteritic anterior ischemic optic neuropathy (NAION)is a common optic neuropathy seriously affecting the visual function in the middle-aged and elderly population.However,its pathogenesis is not completely clear,and therefore its treating efficacy is dissatisfactory.The current study on NAION is focused on the establishment of suitable animal model and the pathogenesis.In recent years,the relatively ideal animal models(including rodent and primate) have been established by photodynamic methods,which make people have more in-depth understanding on the pathophysiologic mechanism of NAION and lay the basis for the research of therapies.The selection of experimental animals,various induction methods and existing problems in the creation of NAION animal model were reviewed and analyzed in this artical.

Objective: To study the effect of different dietary fatty acid compositions on breast tumors induced by methyl-nitrosourea(MNU) in rats. Method: Female SD rats were fed diets containing 15% fat (wt/wt) in the experimental period. At age of 50d, rats were randomly assigned to 8 groups and each group was suldivided into tumor group and control group. The tumor group was given a single ip injection of MNU (50 mg/kg bw) and switched to one of 8 different diets containing following fatty acids: saturated fatty acid(SFA); monounsaturated fatty acid(MUFA); n-6 polyunsaturated fatty acid(PUFA); n-3 PUFA; 1∶1 n-6/n-3; 5∶1 n-6/n-3; 10∶1 n-6/n-3; 1∶2∶1 S/M/P(n-6/n-3 at 1∶1) for 18w. The control groups received the physiological saline only. The weight growth, mammary tumor incidence, tumor multiplicity, and tumor latency were observed. Results: Except the weight growth was arrested in rats fed on n-3 PUFA 6w later, there was no significant difference in weight growth among the other groups. Additionally, there was no mammary tumor occurrence in control groups, but in model groups, the incidence of mammary tumors in rats fed on SFA, MUFA, n-6 PUFA,5∶1 n-6/n-3, 10∶1 n-6/n-3 and 1∶2∶1 S/M/P diets was twice higher than that in rats fed on 1∶1 n-6/n-3 diet, although there was also no tumorin rats fed on n-3 PUFA diet. Moreover, tumor multiplicity in rats fed on 1∶1 n-6/n-3 diet was obviously decreased in comparison with those groups, and tumor latency was prolonged too. Conclusion: The different dietary fatty acid compositions can diversely influence MNU-induced breast tumors incidence in rats and 1∶1 n-6/n-3 has obvious inhibitory effect.

Along with the progressing of micro-electronics technology and the improving of FPGA's performance, it's more and more common to process digital signals using FPGA. In most cases, FPGA is used to do the preprocessing or postprocessing besides processor in order to get a higher processing speed. This article introduces how to construct the signal processing unit of Doppler measurement system with FPGA and universal digital signal processor.

Objective To discuss the application value of the treatment protocol of combining warm needling and atorvastatin in treating female cardiac syndrome X (CSX). Method Eighty female CSX patients were randomized into a control group and an observation group by the random number table, 40 cases in each group. The control group was intervened by atorvastatin in addition to the conventional treatment protocol, while the observation group was by warm needling plus atorvastatin in addition to the conventional treatment. The treatment efficacies and adverse events rates were compared between the two groups. Result There were no significant between-group differences in comparing the component and total scores of the Cardiac Anxiety Questionnaire (CAQ), NO, plasma endothelin (ET-1) and hypersensitive C-reactive protein (hs-CRP) levels before the intervention (P>0.05);after 8-week treatment, the component and total scores of CAQ, ET-1, and hs-CRP levels were significantly lower in the observation group than in the control group, and NO level was significantly higher in the observation group than in the control group (P<0.05). Meanwhile, at the end of the 8-week treatment, the total effective rate of the observation group was significantly higher than that of the control group (P<0.05). Besides, there was no significant difference in comparing the adverse events rate between the two groups during the 8-week treatment (P>0.05). Conclusion In the treatment of female CSX, warm needling plus atorvastatin can enhance the treatment efficacy.

ObjectiveTo implement two typical algorithms, Marching Cubes and Ray-casting, of medical image 3-D visualization using Visualization Toolkit (VTK) with VC++.MethodsSkull and scarfskin of brain were reconstructed based on CT data. Results and ConclusionVTK is a powerful tool with many advantages, such as easy to use, fast, good interaction ability, good results for image reconstruction and so on.

Objective To study the reliability of the four rating scales which are widely used. Methods 260 consecutive inpatients fromAug. 2007 to Oct. 2008 with white matter lesions were enrolled into the study. Interrater and intrarater reliability of four scales was analyzedby using kappa correlation. Internal consistency was expressed with Cronbach's α. Results All the scales have statistic significant interraterand intrarater reliability. Scale of Ylikoski has the best intrarater reliability and Cranach's α (intrarater reliability, kappa=0.656, P<0.01, Cranach'sα=0.901). Conclusion The four rating scales for white matter lesions have advantage and disadvantage. Disparate rating scales shouldbe used according to purpose of study.

OBJECTIVETo explore the intergrating of N-isopropyl oxamate and serum protein and establish a high performance liquid chromatography (HPLC) detection method of N-isopropyl oxamate (specific inhibitor of testis-specific lactate dehydrogenase (LDH-C4)) in the blood of plateau pikas.

METHODSTwenty highland pika 150-200 g, were randomly divided into two groups (n = 10): control group and inhibitor group. Different concentrations of N-isopropyl oxamate were added to examine the intergrating of N-isopropyl oxamate and serum protein. In order to determine its concentration in the pika blood accurately, we used the method of adding trypsin to incubate the serum first, followed by trichloroacetic acid treatment and detecting by HPLC. Results: When the concentrations of N-isopropyl oxamate in the pika serum were added to 0.05 mmol/L, 0.1 mmol/L, 1 mmol/L, 10 mmol/L, 16.7 mmol/L, 33.3 mmol/L and 100 mmol/L, the intergrating rates between N-isopropyl oxamate and plateau pika serum were 100%, 100%, 100%, 86.84%, 54.11%, 40.10% and 20.18%, respectively. The method established in this paper was good on recovery rates, precision and stability. A good linearity was obtained in the range of 0.0125-0.25 mmol/L. When the concentrations of N-isopropyl oxamate in the serum were added to 0. 15 mmol/L,0.3 mmol/L and 1 mmol/L, the recovery rates were 98.05%, 98.98% and 98.12%, respectively; the precision relative standard deviation( RSD) of concentrations were 1.17%, 0.92% and 0.83%, respectively; the stability relative standard deviation (RSD) of concentrations were 1.38%, 1.40% and 0.88%, respectively. The repeatability RSD of the method was 1.76%. Quantitative limit was 0.0125 mmol/L.

CONCLUSIONN-isopropyl oxamate has a strong affinity with plateau pika serum protein that can't be accurately determined with common HIPLC method. It can be accurately determined in the blood by adding trypsinto digest the serum protein first, followed by adding trichloroacetic acid to precipitate the protein.

Objective To investigate the pathophysiological distinction of the functional connectivity between right temporal parietal junction(rTPJ) and whole brain in children with attention-deficit/hyperactivity disorder(ADHD) on resting-state functional magnetic resonance imaging(fMRI) and explore the neurological mechanisms of ADHD at the point of functional connectivity.Methods Resting-state functional magnetic resonance imaging scans were obtained in 30 children with ADHD from The Third Affiliated Hospital of Soochow Univcrsity and another 33 with age and gender matched controls from a normal primary school over the same period, and then,blood oxygenation level dependent(BOLD) signal was acquired to calculate the functional connectivity of rTPJ with other brain regions.Significant differences of connectivity intra-class and between groups were analyzed.Also, the correlation between the connectivity strength and the ADHD rating scales were tested.Results The pattern of functional connectivity of the rTPJ for the ADHD group was similar to that of the normal control group.Compared with the normal controls, the left superior temporal gyrus (MNI coordinates-33,6,48) , the right anterior c ingulate coltex(MNI coordinates 6,39,-3) , the right inferior parietal lobule (MNI coordinates 42,-33,30) , the left medial frontal gyrus(MNI coordinates-3,63,-18) in children with ADHD sbowed an increased resting-state functional connectivity with the whole brain ,while the right middle temporal gyrus(MNI coordinates 57,-33,-12) , the right cingulate gyrus(MNI coordinates 18,-21,36) showed a decreased resting-state functional connectivity with the whole brain.The average connection strength between the rTPJ and the whole brain showed positive correlation with the ADHD scores,while in normal controls,it showed negative.The connection strength between the rTPJ and those 6 brain areas with significant statistical difference was relevant to the ADHD scores,but they had no statistical significance.Conclusion The functional connection abnormalities between tbc rTPJ and the whole brain in children with ADHD may be relevant to the clinical symptom of attention-deficit.

Objective To investigate the distribution and drug resistance of pathogens for hospital-acquired urinary tract infections between patients in internal medicine wards and in surgical wards .Methods A total of 586 midstream urine samples were collected from patients in the First Municipal Hospital of Qinhuangdao during January 2012 and December 2014.Vitek 2 Compact system was applied in bacteria identification and drug sensitivity tests .Excel and SPSS 11.5 software were applied for data analysis . Results A total of 661 strains were isolated , in which 404 strains were from internal medicine wards and 257 strains were from surgical wards .Escherichia coli (44.6%vs.33.1%) and Enterococcus (23.0%vs. 16.3%) infections were more common in the internal medicine wards (χ2 =8.620 and 4.309, P<0.05), while the occurrence of Pseudomonas aeruginosa infection (4.0%vs.24.5%) was higher in surgical wards (χ2 =63.056, P <0.01).Escherichia coli and Klebsiella pneumonia strains were highly sensitive to piperacillin/tazobactam, cefptetan, amikacin, imipenem, and meropenem, and the sensitivity rates were from 85% to 100.0%.The sensitivity rates of Escherichia coli to ampicillin/sulbactam, levofloxacin and ciprofloxacin were <30%, and strains from surgical wards had lower sensitivity rates to these drug than those isolated from internal medicine wards (χ2 =4.987, 4.575 and 5.359, P<0.05).The sensitivity rates of Klebsiella pneumonia isolated from internal medicine wards to ceftazidime , gentamicin and aztreonam were 68.8%, 60.6% and 69.7%, which were higher than those isolated from surgical wards (36.0%, 32.0%, and 40.0%), and the differences were of statistical significance (χ2 =6.068,4.661 and 5.115, P<0.05).Pseudomonas aeruginosa strains were highly sensitive to piperacillin/tazobactam and amikacin, and the susceptibilities of strains isolated from surgical wards (98.4%and 96.8%) were higher than those isolated from internal medicine wards (75.0% and 81.3%) (χ2 =11.797 and 5.221, P <0.05). Pseudomonas aeruginosa strains isolated from surgical wards were also highly sensitive to cefepime (92.1%), but the sensitive rate of strains from internal medicine wards was only 37.5%, and the difference was of statistical significance (χ2 =24.696, P<0.01).Enterococcus faecium and Enterococcus faecalis were sensitive to tigecycline , vancomycin and linezolid with the sensitivity rates over 95%.Except quinupristin/dalfopristin and tetracycline , the sensitivities of Enterococcus faecalis to other antibiotics were higher than Enterococcus faecium.Susceptibility of Enterococcus faecium from surgical wards (33.3%) to moxifloxacin was lower than those from internal medicine wards (70.8%), and the difference was of statistical significance (χ2 =4.629, P <0.05).Conclusion There are differences in distribution and antimicrobial susceptibility of pathogens isolated from internal medicine wards and from surgical wards .