Objective To investigate the expression of vascular endothelial growth factorC(VEGF-C),its receptor3(VEGFR-3) and podoplanin in tissue of esophageal cancer,and the relationship between their expression and tumor lymphatic metastasis.Methods Expression of VEGF-C,VEGFR-3 and podoplanin in 76 cases of ESC was detected by immunohistochemical SP method and lymphatic vessel density(LVD) was calculated.Results Positive immunostaining of VEGF-C in esophageal cancer tissue was 63.1%;the expression of VEGF-C was significantly associated with the depth of lymph node metastasis and tumor invasion(P

Objective To investigate the expression of vascular endothelial growth factor C(VEGF-C ) in tissue, serum and lymph fluid in esophageal cancer patients, and the relationship between its expression and tumor lymphatic metastasis. Methods Expressions of VEGF-C in 76 cases of ESC was detected by immunohisto-chemical SP method and VEGF-C levels in lymph fluid and serum were assessed by enzyme-linked immunosorbent assay. Results Positive immunostaining of VEGF-C in esophageal cancer tissue was 63.1%,The expression of VEGF-C in tissue was significantly associated with lymph node metastasis and TNM stage ( P<0.01, P<0.05 respectively), but not to patient age, tumor length or differentiation; VEGF-C in lymph fluid is significantly higher than in serum( P<0.05) ; The expression of VEGF-C in lymph fluid end serum were significantly associated with lymph node metastasis( P<0.05). Conclusion There are cliuical significance between VEGF-C expression and lymph node metastasis、TNM stage in tissue of esophageal cancer. The level of VFGF-C in lymph fluid is higher than that in serum, both associate with lymph-node metastasis closely.

Objective To analyze the epidemiological characteristics of hospital admission cases with chemical poisoning in Guangdong Province from 2016 to 2020. Methods Data of hospital admissions for chemical poisoning in Guangdong Province from 2016 to 2020 were collected through Guangdong Province Health Statistics Network Reporting System，and descriptive analysis was conducted. The seasonal characteristics of the number of hospitalized poisoning cases were analyzed by the concentration method，the seasonal index（SI）was calculated by the weighted annual ratio averaging method，and the spatial auto-correlation of regional poisoning trend was analyzed by the global and local spatial autocorrelation. Results From 2016 to 2020，the number of hospital admissions for chemical poisoning in Guangdong Province was 54 656，showing a general decreasing trend. The sex ratio（male to female）was 0.90 ∶1.00. The top three types of hospitalization rates were carbon monoxide poisoning，alcohol poisoning and organic solvent poisoning. The main poisoning groups were students and children， farmers，workers and unemployed people，accounting for 31.74%，18.53%，13.91% and 10.39%，respectively. The 74.37% of poisoning cases were cured or improved and discharged，and the case fatality rate was 0.48%. The top three hospitalization rates in age group of 0-<5 years were organic solvent，metal and carbon monoxide poisoning. The hospitalization rate of carbon monoxide poisoning ranked the first among all age groups of ≥5 years. The top three regions with the highest average annual hospitalization rate were Shaoguan City （25.14/105 ），Qingyuan City （17.04/105 ） and Meizhou City （16.09/105 ）. Carbon monoxide poisoning had a strong seasonality（M=0.77），with high incidence months of January，February and December（SI were 3.60，3.08 and 2.48，respectively）. The inpatients with chemical poisoning showed non-random distribution and spatial correlation（all P<0.01），with a high-high clustering among 13 districts and counties in northern Guangdong（all P<0.05）. Conclusion The number of hospital admission cases of chemical poisoning showed an overall decreasing trend in Guangdong Province from 2016 to 2020. The main types of poisoning were carbon monoxide poisoning，alcohol poisoning and organic solvent poisoning. The spatial distribution of chemical poisoning types showed spatial correlation and there were high-high clustering areas.

Objective To approach the method for improving the intellectual development,of whom had suffered from parity′s brain damage.Methods The patients were divided into 2 groups randomly(age range from 7 days to 18 months) who were observed and compared for 3 years.Group A was bundle of intervention which had been under early intervention program since infant.Group B was bundle of comparing of which had not been under early intervention.Results Observed for 6 months and 12 months,the intellectual development of group A was prior to that of group B(age 6 months P

OBJECTIVE To understand the distribution and the drug resistance of the pathogenic bacteria so as to guide rational application of antibiotics for clinics.METHODS Bacteria culture and drug sensitivity with urine specimen were done among 1513 cases with urinary tract infection.RESULTS Urinary infection was mostly due to Gram-negative bacilli.Gram-positive cocci and fungi were the second.The top four pathogens were Escherichia coli(47.5%),Enterococcus faecium(8.7%),Candida albicans(7.0%),and Klebsiella pneumoniae(6.5%).The positive rates of urinary smear and culture were 51.9% and 29.3%,respectively with a coincidence rate of 77.4%.The drug resistance rates against imipenem,vancomycin and linezolid were zero,with 19.3% and 34.5% against extended-spectrum ?-lactamases-producing E.coli(ESBLs) and K.pneumoniae together,with 33.3% and 58.2% against meticillin-resistant coagulase negative Staphylococcus(MRCNS) and high-level gentamicin resistance(HLGR).CONCLUSIONS Urinary smear,bacteria culture and drug sensitivity tests can offer the basis for clinical rational use of antibiotics.

Animals ; HSP72 Heat-Shock Proteins ; metabolism ; Hypoxia ; metabolism ; physiopathology ; Male ; Motor Activity ; physiology ; Muscle, Skeletal ; metabolism ; Oxygen ; metabolism ; Physical Exertion ; physiology ; Rats ; Rats, Sprague-Dawley ; Time Factors

While the near infrared spectroscopy (NIRS) is used to measure the inhomogeneous samples with diffuse reflection mode, the accuracy and robustness of the calibration model is not quite good for the variation of spectrum scattering and absorption coefficient in those samples.Therefore, an establishment strategy of hybrid model based on homogeneous sample and calibration transfer method was proposed to solve the problem of detection inhomogeneous samples by NIRS.This work was focused on the tobacco leaf samples aspect.Three common calibration transfer methods, including Shenk′s patented algorithm (Shenk′s), piecewise direct standardization (PDS) and calibration transfer based on canonical correlation analysis (CTCCA), were used to construct two hybrid models of tobacco powder mixed with cut tobacco and tobacco powder mixed with tobacco flake samples to predict nicotine content in the samples of cut tobacco and tobacco flake.Experimental results showed that the hybrid model of adding some cut tobacco and tobacco flake samples to the powder model would get preferred prediction ability.Root mean square errors of cut tobacco and tobacco flake samples were reduced by 1.39% and 2.73%, respectively.This showed that the hybrid model was help for the improvement of the predicted results and the robustness of model.Moreover, CTCCA got the optimal performance between these three calibration transfer methods.Therefore, the scheme of building a hybrid model by NIRS homogeneous model and calibration transfer method to determinate the heterogeneous samples is feasible, which can accelerate the development of on-line near infrared spectroscopy technology and will provide reference for the share of near infrared spectral model.

OBJECTIVE: To evaluate the improvement of speech perception in Chinese-native cochlear implant (CI) children using frequency modulated system (FM system). METHOD: The mandarin speech perception (MSP) system was used to evaluate 11 cases with severe and profound hearing loss who were fitted cochlear implants. Listeners were asked to repeat MSP words presented in quiet and several different signal-to-noise ratio (SNR) conditions and percent correct word repetition was determined. Performance was evaluated under FM system and without FM (CI only). In addition, the listeners' subjective performance changes in the experiment were also observed. RESULT: (1) There was significant main effect of the device condition (with FM and no-FM) (F = 72.938, P < 0.01), a significant main effect of signal level (F = 230.715, P < 0.01), a significant interaction effect between the signal level and the device condition (F = 40.893, P < 0.01). (2) Listeners answered the question in a louder voice, showed more confidence, when using with FM system. CONCLUSION FM system could improve the speech reception in a complex environment for Chinese-native CI children.
Child ; Cochlear Implantation ; Cochlear Implants ; Humans ; Noise ; Signal-To-Noise Ratio ; Speech ; Speech Perception ; Speech Therapy

0.05). On day 4, GI, SBI and OS were lower than those on day 1 (P0.05). On day 8, the parameters were lower than those on day 4(P0.05). Conclusion: 1 g/L cetylpyridinium chloride is effective in the treatment of simple gingivitis.

Objective:In order to explore the function and regulation of intercellular adhesion molecule 1(ICAM 1)in the early pregnancy.Methods:The expression of ICAM 1 mRNA in endometrium of day 1～8 normal pregnant mice and day 4 pregnant mice injected with leukemia inhibitory factor interleukin 1? were detected with RT PCR.Results:Levels of ICAM 1 in endometrium of various periods of pregnancy mice began to increase on day 2 of pregnancy, went up to the highest on day 4, then decrease slowly. The expression of ICAM 1 in endometrium of day 4 pregnancy was improved by administration of LIF,IL 1? in vivo(P