Objective To study the clinical efficacy of island skin flap in the repair of skin and subcutaneous soft tissue defects caused by excision of malignant tumour in the skin. Methods Island skin flaps with the main artery and its penetrating branches were used to repair the skin and soft tissue defects in different sites after malignant tumour removal. A total of 5 cases were repaired, in which 2 cases were in the face, 2 in limb and one in wall of the chest. Results Among the 5 cases, one was repaired with island skin flaps with the main artery, and another 4 were repaired with island skin flaps with the penetrating arteries. Follow-up for one to 5 years showed that the appearance and function in the repaired sites were normal without blood flow disturbance and dysfunction of the island skin flap, and no recurrence of the tumors except one case. Conclusion The island skin flap with main artery, especially one with its penetrating branches, is a good option to repair the defect caused by removal of malignant tumors with high rate of success, better appearance and minor damage to the donor site.

Diabetes is a common disease,serverely harmful to the human's health and life quality.The pancreatic islets transplantation can correct the patient's hyperglycemia,stop or even reverse the progress of the complication and thus decrease the mortality of diabetic patients.It is the most safe and efficient therapy for diabetes.Since the Edmonton Protocol got success in pancreatic islet transplantation in 2000,it has been more and more interested because of its great clinical curative effect.Research strategy of islet transplantation is now focussed on increasing the acquired islets with normal viability,selecting the best transplantation pathway,and improving the immunosuppression protocol.The shortage of human pancreatic donor is an ever unsolved problem in clinical application.The potential resolutions may include acquisition from xenogenic-islets;islets originated from stem cells,and islets from the living-donor human pancreas.The islets transplantation will open a new application field for interventional radiology.(J Intervent Radiol,2006,15: 577-579)

This paper analyzes the newest CT and MR products and compares their new technology and clinical application.The development of image inosculation technology is also briefly discussed.

Objective To study the operative methods and clinical outcome of laparoscopic ileal colpopoiesis with long vascular pedicle.Methods We reviewed 31 cases which had received ileal colpopoiesis,including 25 cases of congenital absence of vagina and 6 cases of male-to-female transsex.All cases were operated on by laparoscopic(8 cases) and laparoscopy assisted(23 cases) ileal colpopoiesis.The postoperative results were analyzed through physical examination and interview regarding the patient′s functional status and satisfaction during sexual intercourse.Results Ileal colpopoiesis were preformed successfully on all 31 cases.Follow-ups of 3-13 months were done for all of them.Patients used vaginal mould for at least 8 months.All artificial vaginas had excellent cosmetic results,including adequate vaginal length,good lubrication,and appearance and physical functions similar to female natural vagina,and sexual function was reportedly satisfactory.One of the patients had an operative complication of an intestinal obstruction,which was cured by a second operation and other treatments.Conclusions The laparoscopic and laparoscopy assisted ileal vaginoplasty is a feasible,safe and ideal method of current vaginoplasty due to its minor damage,excellent cosmetic results and similarity to normal vaginal features.However,vaginal mould should be used for a long period of time(at least 8 months) after an operation,to prevent vaginal orifice shrinkage.

Objective To investigate the stress response during cardiopulmonary bypass and the effects of propofol on it Methods Thirty one patients scheduled for valve replacement ,were divided randomly into propofol group (group A,n=16) and control group (group B, n=15) Anesthesia was induced with valium fentanyl vencuronium, was maintained with fentanyl enflurane vencuronium In group A propofol 6 8mg?kg -1 ?h -1 was infused intravenously during CPB MAP,venous plasma concentrations of epinephrine(E) ,norepinephrine(NE) and blood glucose were measured before CPB(T1),cooling to 33℃(T2) and 30℃(T3), stable hypothemia(T4), rewarming to 30℃(T5) and 33℃(T6),and 15 min after CPB(T7) respectively Results In rewarming period, NE and E levels in group B increased significantly (P0 05) The dose of sodium nitroprussid was lower in group A than that in group B, and the dose of dopamine was not different between both groups Conclusions The stress response increases in rewarming stage during CPB ,which can be suppressed by the continuous infusion at anesthetic dose of propofol

A growing body of evidence has indicated the important role of autophagy receptors in directing ubiquitinated or non-ubiquitinated cargos towards autophagy. Autophagy receptors bind to LC3 (microtubule-associated protein 1 light chain 3) on phagophore and autophagosome membranes, and recognize signals on cargoes in the delivery system of autophagy. However, the diverse domains in the receptor structures determine that their roles would never be limited to autophagy. Up to date, increasing numbers of the receptor proteins have been demonstrated to serve as a molecular link or switch participating in autophagic degradation, apoptosis or cell survival signals. Here, we highlight the non-autophagic roles of these receptor proteins to draw attention to this growing research topic.
Apoptosis ; Autophagy ; Humans ; Microtubule-Associated Proteins ; physiology ; Signal Transduction ; Ubiquitination

This article briefly summarized conventional k-space technique, partial k-space sampling and key hole technique, then introduced the latest applications during these years.
Magnetic Resonance Imaging

Adolescent ; Altitude ; Anaerobic Threshold ; physiology ; Drugs, Chinese Herbal ; therapeutic use ; Emigrants and Immigrants ; Humans ; Hypoxia ; physiopathology ; prevention & control ; Male ; Oxygen Consumption ; physiology ; Physical Endurance ; physiology ; Phytotherapy ; Young Adult

Objective To evaluate the biocompatibility,immunology and physiologic features of encapsulated Newborn Porcine Islets(NPI) in the liver of the recipient dogs with type I diabetes.Methods Type I diabetic dogs were perfused with 400 000-600 000 encapsulated NPI(group A,n = 15)or unencapsulated NPI(group B,n = 15)through the hepatic artery without immunosuppressive treatment.Liver function and CD4/CD8 in the recipients were measured before and after the transplantation.The livers from all NPI recipient dogs were analyzed by histopathology 6 months after transplantation(Tx).Results Insulin dose administrated to group A was reduced gradually within one week after Tx,from 22 u before Tx to 5 u after Tx,exogenous insulin required for group B was decreased from 24 u to 10 u.However,2 to 3 weeks after Tx,the insulin dose given to group B returned to the original level before Tx.In contrast,the amount of insulin administrated to group A was continually reduced to 8 u.Moreover,CD4+ cells in the blood of group B recipients were higher than that before Tx,whereas no significant alteration of CD4+ cells and CD8+ cells in the blood of group A after Tx.All NPI recipient dogs demonstrated a normal function and structure of the liver after Tx.Conclusion Microcapsulated NPI has a good biocompatibility in recipients livers providing prolong-ation of xenograft survival,and correcting the hyperglycemia of diabetic canines.(J Intervent Radiol,2006,15: 607-610)

Objective: To study the effect of different dietary fatty acid compositions on breast tumors induced by methyl-nitrosourea(MNU) in rats. Method: Female SD rats were fed diets containing 15% fat (wt/wt) in the experimental period. At age of 50d, rats were randomly assigned to 8 groups and each group was suldivided into tumor group and control group. The tumor group was given a single ip injection of MNU (50 mg/kg bw) and switched to one of 8 different diets containing following fatty acids: saturated fatty acid(SFA); monounsaturated fatty acid(MUFA); n-6 polyunsaturated fatty acid(PUFA); n-3 PUFA; 1∶1 n-6/n-3; 5∶1 n-6/n-3; 10∶1 n-6/n-3; 1∶2∶1 S/M/P(n-6/n-3 at 1∶1) for 18w. The control groups received the physiological saline only. The weight growth, mammary tumor incidence, tumor multiplicity, and tumor latency were observed. Results: Except the weight growth was arrested in rats fed on n-3 PUFA 6w later, there was no significant difference in weight growth among the other groups. Additionally, there was no mammary tumor occurrence in control groups, but in model groups, the incidence of mammary tumors in rats fed on SFA, MUFA, n-6 PUFA,5∶1 n-6/n-3, 10∶1 n-6/n-3 and 1∶2∶1 S/M/P diets was twice higher than that in rats fed on 1∶1 n-6/n-3 diet, although there was also no tumorin rats fed on n-3 PUFA diet. Moreover, tumor multiplicity in rats fed on 1∶1 n-6/n-3 diet was obviously decreased in comparison with those groups, and tumor latency was prolonged too. Conclusion: The different dietary fatty acid compositions can diversely influence MNU-induced breast tumors incidence in rats and 1∶1 n-6/n-3 has obvious inhibitory effect.