Glaucoma is an group of ocular disease associated with the degeneration of retinal ganglion cells and it finally causes vision loss.Primary open angle glaucoma (POAG) is a main type of glaucoma worldwide.The primary reason of POAG is elevated intraocular pressure (lOP) caused by the degeneration or dysfunction of the trabecular meshwork (TM).Recent studies showed that stem cell-based therapy becomes a promising approach to treat the degenerative diseases,including POAG.Among multiple types of stem cells,induced pluripotent stem cell (iPSC) is the one with the most clinical potential due to its autologous derivation and non-ethical issue.In this paper,we summarized the encouraging therapeutic effects of iPSCs on POAG from different species,different etiological factors and different pathological stages.Although these encouraging studies suggest that iPSC is a fabulous stem cell type to regenerate the damaged tissue,more efforts are required for clinical application.In addition,we discussed several solutions to improve the safety of iPSCs and provided potential approaches to improve the therapeutic efficiency and specific targeting.Answering these questions will help us to better understand the characteristics of iPSCs and promote the development of bench to bedside research.

Objective To explore the application value of CT value histogram in differential diagnosis between primary hepatoma and other space-occupying lesions in liver.Methods From 2012 to 2013,the imaging data in 243 patients with different isolated space-occupying lesions in liver were analyzed retrospectively who underwent both enhanced and unenhanced abdominal CT scans. The lesions were confirmed as hepatic cyst,hepatic hemangioma or primary hepatoma by pathological and other clinical proofs and divided into 3 groups.The histograms of plain scan and post-contrast triphases were drawn respectively using an attached picture-making software.Relevant data of the histograms were analyzed and compared using the SPSS among three groups.Results The CT value histograms of hepatic cysts,hemangiomas and majority of hepatomas presented normal distribution curves.Negative skewness distribution curve was showed in the tumor within necrosis and liquefaction,whereas the positive curve was showed in hepatoma with more calcification.Some significant differences in the Mean,SD,Max,Min,and R values were confirmed.Conclusion Skew-ness distribution curve has a relative high specificity in diagnosis of primary hepatoma.Both dramatic decrease of the Mean value in delayed phase and obvious increase of the R value in plain scan suggest the possibility of primary hepatoma.

ObjectiveTo assess the reliability and validity of the Chinese version of the rejection sensitivity questionnaire(RSQ).Methods813 college students were investigated with RSQ and each caregiver was retested 4 weeks later.Results ( 1 ) All items had good discrimination.(2) Exploratory factor analysis showed the Chinese version of RSQ consisted of three factors which could explain 45.986％ of the total variance.Confirmatory factor analysis indicated that there was high fitting degree between the three-factor model and the two-dimension model.They were significantly correlated with RSQ total score( r =0.661 ～ 0.851,P ＜ 0.001 ).(3) The Cronbach's alpha coefficient was 0.809.The three factor's Cronbach's alphas were 0.684,0.631 and 0.534 respectively.The test-retest coefficient was 0.892 (P ＜ 0.001 ).ConclusionThe Chinese version of RSQ is a reliable and valid measurement for assessing the rejection sensitivity of the Chinese college students.

Xinshu (BL 15), Feishu (BL 13), Pishu (BL 20), Ganshu (BL 18), Shenshu (BL23) and Geshu (BL 17) were selected and the needles were retained for 30 min. After the needles were taken out, cupping method was applied on each acupoint. In the treatment of total 36 cases of hyperlipidemia, the results showed remarkable effect in 22 cases, effect in 9cases and failure in 5 cases, and the total effective rate in 86.1%.

Professor Macer summarizes the essence and concepts of bioethics with love as the universal ethical basis,but it effective resources and evidence proves to be limited.In fact,the "love" could be the motive of ethics rather than the basis of ethics.For the origins of ethics are vastly related with compassion and mercy.

Objective To study the factors influencing the assay of ? 1 antitrypsin(? 1 AT) bioactivity. Methods Various concentrations of PEG(MW, 4000), sucrose, sodium citrate and ethanol were added before determining ? 1 AT activity. Results ? 1 AT activity increased approximately 100% compared with the controls when the PEG concentration reached 20%. Conclusion PEG concentration influences the ? 1 AT activity assay.

Adaptor Proteins, Signal Transducing ; genetics ; Bone Marrow Diseases ; genetics ; pathology ; DNA Mutational Analysis ; DNA-Binding Proteins ; genetics ; Exocrine Pancreatic Insufficiency ; genetics ; pathology ; Glucose-6-Phosphatase ; genetics ; Humans ; Leukocyte Elastase ; genetics ; Lipomatosis ; genetics ; pathology ; Mutation ; Neutropenia ; congenital ; genetics ; Proteins ; genetics ; Transcription Factors ; genetics

Health Promotion ; methods ; Humans ; National Institute for Occupational Safety and Health (U.S.) ; Occupational Health ; United States

Objective To investigate the relationship between hepatic potential capacity and the pharmcodynarnics of rocuroniurn.Methods The indocyanine green (ICG) excretion test waspertormed one day before operation in 71 patients with decompensated hepatic cirrhosis scheduled to receive devascularization combined with splenectomy.On the basis of ICG retention at 15 min(ICGR_(15)),the patients were divided into groups of I_1(22 cases,ICGR_(15)≤10),I_2(35 cases,1020).Another 20 healthy people(group C)were taken as thecontrols.Rocuronium 0.6 mg/kg was intravenously infused and 0.3 mg/kg rocuronium、was addedwhen T_1 value recovered to 25%control value.The twitch high of adductor pollicis muscle wasrecorded.The time of onset,T1 maximum depression,the clinical duration of initial dose,and thespontanous recovery index were recorded.The clinical duration of repeated maintenance doses and themean dosage of each group were recorded as well.Results The onset time,25% TOF responsePeriod and the recovery index after operation were significantly prolonged in groups of I_2 and I_3compared with those in groups of C and I_1(P<0.05 or P<0.01).No response period of grouP I_3was longer than that of other three groups(P<0.0 1).When the maintenance dose of rocuronium wasadded for more than four times,the clinical action time also showed to be prolonged in an older of I_3>I_2＞I_1 and mean dose reduced in an order of I_3

Objective To evaluate therapeutic effects of hyperthermia therapy in combination with chemotherapy for the treatment of nonsmall cell lung carcinoma. Methods Fifty-two patients with non-small cell lung carcinoma underwent hyperthermia therapy in combination with chemotherapy(NP regimen) in this hospital between September 2003 and November 2006.The therapeutic effects were evaluated after 3 cycles of the combination therapy,and were compared with those from 16 patients receiving only chemotherapy between January 2006 and November 2006.Results The combination therapy offered significantly better curative short-term effects than the simple chemotherapy.The total response rate was 65.4%(34/52) for the combination therapy and 37.5%(6/16) for the simple chemotherapy(Z=-2.419,P=0.016).Significant pain relief was achieved in patients after the combination therapy,while no analgesic effect was noted after the simple chemotherapy,the difference between the two groups of patients being statistically significant(Z=6.486,P=0.000).There was no significant difference in the incidence of complications between the two groups,which mainly included nausea,granulocytopenia,thrombocytopenia,and abnormal liver functions.Conclusions Hyperthermia therapy in combination with chemotherapy compares favorably to simple chemotherapy in the treatment of non-small cell lung carcinoma.