B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation. However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmune disorders. In the paper, we introduced the mechanisms of BLyS and a proliferation-inducing ligand (APRIL) regulating T cell responses and their roles in rheumatoid arthritis (RA).

Drug treatment is one of the most important parts in t he therapeutics of periodontal disease. This review discusses the purpose, signifi cance、pharmacological mechanisms, administration methods and announcements of c linic medication in periodontal disease and summarized clinical commonused drug as well as the reseach progress in drug therapeutics of periodontal disease.

Objective: To evaluate the effectiveness of minocycline at subantimicrobial dosage in the treatment of experimentally induced periodontitis in rats.Methods: Periodontitis was induced by silk ligature technique on 4 second molars in each of 16 adult male Sprague-Dawley rats and the animals were fed with 100 g/L sucrose drink. The rats were divided into 2 groups: (1)periodontitis group without treatment;(2)treatment group, the rats with periodontitis were treated by systemic administration of minocycline at 5 mg/(kg?d).Another 8 normal rats were used as the controls. Assessment was carried out at day 28 and 56 using a number of different visual, histological and ultrastructure approaches.Visual assessment included tooth mobility(TM), gingival index(GI), and alveolar bone loss. Histological examination included monocyte effusion,resorption lacunae with osteoclasts and percentage of the periodontal collagen.The collected data were statistically analyzed using variance test.Results: Systemic administration of minocycline at subantimicrobial dosage can significantly reduce GI, TM, resorption lacunae with osteoclasts and alveolar bone loss either at day 28 or at day 56; significantly inhibited monocyte effusion and the collagen degradation in the periodontium at day 56 in rats with periodontitis. Conclusion: Minocycline at subantimicrobial dosage may decrease alveolar bone loss and osteoclasts formation in periodontium with periodontitis.

Objective To study the effects of laparoscopic radical gastrectomy for gastric cancer on serum inflammatory cytokines and intestinal barrier function in patients.Methods Retrospective analysis was used to investigate a total of one hundred and forty gastric cancer patients in Ezhou Central Hospital from January 2014 to September 2016,including 66 cases with laparoscopic radical gastrectomy (laparoscopic group) and 74 cases with traditional open radical gastrectomy (traditional group),the perioperative indexes,inflammatory factors and intestinal barrier function of the two groups were compared.Results In the laparoscopic group,the amount of bleeding loss in the laparoscopic group ((86.8 ± 15.2) ml),the incision length ((6.2 ± 1.4) cm),the first anal exhaust time ((3.0 ± 0.6) d),the fluid diet time ((4.6 ± 0.9) d),the postoperative hospitalization ((8.8 ± 1.7) d) were all lower than those in the traditional group ((158.2±25.0) ml,(16.3±2.7) cm,(3.6±0.7) d,(5.1±0.8) d,(10.3±2.5) d),the differences were statistically significant (P=0.000,0.000,0.000,0.014,0.001);the operation time of the traditional group was (196.5±27.8) min,the number of lymph nodes was (21.6±2.8),compared with those in the laparoscopic group ((192.5±30.3) min,(22.0±3.1),P=0.421,0.137).The levels of WBC,IL-6,CRP,TNF-ɑ,COR,plasma D-lactic acid and diamine oxidase in the laparoscopic group were lower than those in the traditional group (P=0.000).Conclusion The effect of laparoscopic radical gastrectomy on serum inflammatory cytokines and intestinal barrier function in patients is not obvious.

The diagnosis of the hip diseases and the judgment of the treatment are based on the measurement parameters with X-rays that mainly defined as anterposterior pelvis radiographs of the hip joint.The data of the measurement changes in different ages due to the growth and development of children's bodies.There are varies of parameters attempt to improve the evaluation of the hip joint.The review focuses on the Chinese and English literature since 1930s,and summarizes the introduction of the history and current condition,modified progress of methods and data analysis of measuring results.

Objective:To compare the clinical factors and physical parameters between 3-fields and 4-field 3-dimensional con-formal radiotherapy(3DCRT)for mid-thoracic or upper-thoracic esophageal carcinoma.Methods:Patients with mid-thoracic or upper-thoracic esophageal carcinoma were chosen at random and treated with 3DCRT.Contouring and treatment planning were performed with VARIAN Eclipse treatment planning system(TPS).The target volume was determined according to guidelines from ICRU Report No.50.The three-beams treating plan and the four-beams treating plan were performed and a 8mm isotropic mar-gin was added for the planning target volume(PTV)in beam setting.The different plans were evaluated with dose volume histograms(DVH)in terms of dose coverage of PTV and protection of organs at risk(OAR).The prescribed dose was 60 Gy/30 F to the PTV.Results:There was no significant difference in the dose coverage to PTV and the explored dose to spinal cord with the two model of 3DCRT.When the three-beams treating plan was compared with four-beams treating plan,lungs V20 and V30 were significantly better,and at the same time lungs V5 was higher.Conclusions:3-fields 3DCRT is better than 4-fields 3DCRT with lower lungs V20 and V30 so as to prevent acute radial injury of lungs in radiotherapy of mid-thoracic or upper-thoracic esophageal carcinoma.

Cerebral Cortex ; growth & development ; physiology ; Evoked Potentials, Visual ; physiology ; Humans ; Infant, Newborn ; Infant, Premature ; growth & development ; Sensory Thresholds ; physiology ; Vision, Ocular ; physiology ; Visual Acuity ; physiology ; Visual Perception ; physiology

Humans ; Microsurgery ; Otologic Surgical Procedures

Objective To explore the relation among physical exercise,depression among female college students and social support,and the multiple mediation effect of three dimensions of social support between physical exercise and depression.Methods A total of 300 female college students were selected and investigated using the physical activity rating scale-3 (PARS-3),self-rating depression scale (SDS) and social support rating scale(SSRS).The multiple mediation effects of the subjective support,objective support and support utilization were tested using the hierarchical regression and the bias-corrected non parametric percent Bootstrap method.Results The overall effect of multiple mediation was significant,accounting for 56％ of the total effect,while the direct effect of physical exercise on depression was not significant.As for the multiple mediation effects,the mediation effect of subjective support and support utilization was significant,while that of the objective support was not.Their mediation effect accounted for 47.3％,36.6％ and 16.1％ of the indirect effect respectively.Conclusion Social support has a mediation effect between physical exercise and depression among female college students,and the subjective support and support utilization are the main mediation factors.

Objective To investigate the maximum epiphyseal width lateral to Klein' s line (MEWLKL) and modification of Klein's Line (namely difference value of bilateral MEWLKL) on hip plain radiographs of normal children, and to investigate the relationship between MEWLKL and modification of Klein's Line and gender and body side, respectively.Methods Anteroposterior (AP) view pelvic plain radiographs of fourteen thousand eight hundred and thirty-seven cases aged from zero to fourteen years old in Shengjing Hospital of China Medical University from 2005 January to 2014 December were reviewed.Seven thousand one hundred and forty-seven normal AP pelvic plain radiographs were included in the present study.Fourteen groups based on the age from one years old to fourteen years old were divided.One hundred cases in each age group, including fifty males and fifty females, were randomly selected.Fourteen hundred AP view pelvic plain radiographs including twenty eight hundred hips were measured.The reference value of MEWLKL and modification of Klein's line were measured using AutoCAD2007 software.the Normal distribution test were performed using Excel and SPSS19.0 software.The relationship curve between MEWLKL and modification of Klein's Line and age were drawed.The intra-group difference between MEWLKL and gender and body side were performed using t-test in normal children.The inter-group difference between modification of Klein's line and average MEWLKL were performed using one-way analysis of variance in normal children.Results The reference value of MEWLKL and modification of Klein's Line were both normal distribution.Average reference value of MEWLKL were (5.20 ± 1.92) mm, (5.04 ± 1.88) mm in male, and (5.36 ± 1.94) mm in female (P =0.000), (5.06 ± 1.87) mm on the left side, and (5.33 ± 1.96) mm on the right side (P =0.000).The curve of reference value of MEWLKL in fourteen general groups were similar to those of fourteen male groups and fourteen female groups, and reference value of MEWLKL increased with age.It was in the trough at the age of five [general groups: (3.77 ± 1.00) mm;male groups: (3.53 ± 1.00) mm;female groups: (4.01 ±0.94) mm], and it was at the peak at the age of thirteen [general groups: (7.49 ± 1.43)mm;female group: (7.84 ± 1.42) mm].It was at the peak at the age of fourteen in male groups, and the value was (7.24 ± 1.46) mm.The reference value of MEWLKL in fourteen groups and in female groups both fell slightly after the age of fourteen.There were second trough, (6.44 ± 1.86) mm to (6.38 ± 1.15) mm,at age eleven to twelve in female groups.The curves of reference value of MEWLKL on bilateral sides was very similar, and they increased with age.They were in the trough at the age of five [(3.54 ± 0.84) mm in left side and (4.00 ± 1.10) mm in right side], and they were at the peak at the age of thirteen [(7.25 ± 1.57)mm in left side and (7.72 ± 1.24) mm in right side].The curves both fell slightly after the age of fourteen.The general reference value of modification of Klein's line was (0.93 ±0.82) mm.The average value of each age group waved in the level of 1.0 mm.Statistical significance were found in comparison of two intergroups, age eight versus age seven (P =0.011), and age eleven versus age ten (P =0.04).The maximum value of modification of Klein's line in four of fourteen groups were greater than 2.0 mm, including 2.02 mm in age ten, 2.05 mm in age eleven, 2.3 mm in age thirteen, and 2.17 mm in age fourteen, respectively.Conclusion The value of modification of Klein's line in normal children can be more than 2.0 mm, and the average value waved in the level of 1.0 mm.It is not reliable to determine slipped capital femoral epiphysis using modification of Klein's line.