Objective To investigate the effects of MK-801 on the rat F-VEPs during the critical period of visual plasticity.Methods We performed the F-VEPs examination in the normal Long Evans rats and the MK-801 treated rats on their postnatal days 14 and 28.Results After eye-opening,the latency of F-VEP main wave became shorter(P

Objective To investigate the effect of infecting betamethasone dipropionate 5mg/betamethasone disodium hydrogen phosphate 2mg in articular genu cavity on osteoarthritis.Methods 100 patients were randomly divided into two groups, the treatment group and the control group. The treatment group was treated with diprospan,injected into the inside of knuckle. The control group was treated with oral administration NSAIDs. Results In treatment group the rate of amelioration was 84% after one injection,the rate of amelioration was 90% after one course of treatment. Conclusion Injected diprospan into the inside of knuckle could relieve pain of arthritides, improve the function of arthrosis.

0.05). The screening tests for LA is simple and reproducible and it may be useful in clinical study of SLE.

To observe the high glucose concentration on proliferation and fibronectin (FN) synthesis of glomerular mesangial cells (GMC),a culture of human GMC was established and the cell proliferation was assessed using MTT method and cell counting, and the changes in FN was analyzed with RT PCR and ELISA. It was found that high glucose concentration inhibited GMC proliferation and increased FN synthesis in dose and time dependent manner.The results suggest that hyperglycemia may have important role in the development of diabetic nephropathy.

Laboratory study is an important part of medical research.In the past few years,many significant biosafety incidents occurred in the medical field in and out of China.We here try to analyse the problem of biosafety management of laboratories,stating the importance of biosafety management in laboratory,and put forward countermeasures.

Objective To observe the clinical short-and long-term curative effect of the surgical treatment of female stress urinary incontinence (SUI) with tension-free vaginal tape-obturator (TVT-O) treatment,and discuss the safety of the operation and postoperative quality of life.Methods The data were collected from 130 patients with SUI who were underwent TVT-O treatment.The patients'perioperative period,follow-up of postoperative complications,and comparison of the quality of life before and after surgery were analyzed retrospectively.Results A total of 130 patients was successfully completed their surgeries with a mean operative time (47.01 ± 18.82)min,average blood loss (64.38 ±99.62)ml,mean catheterization (2.67 ±0.90)d,and the average length of stay (4.73 ±2.14)d.A total of 101 cases was completed the postoperative follow-up with (a) preoperative quality of life in patients with ⅡQ-7 score 6 to 21 points and an average of (15.74 ± 3.87) min,(b) symptoms of lower urinary tract UDI-6 score of 3 to 22 minutes and the average (10.51 ± 3.70) min,(c) postoperative quality of life improved significantly ⅡQ-7 score from 0 to 21 points and an average of (1.59 ±4.37)points,and (e) UDI-6 score 0 to 14 points and an average of (1.63 ± 2.66)points.A total of 73 patients (72.3％) had the postoperative urinary incontinence,which subjective symptom were completely cured,significant improvement was 11 cases (10.9％),ineffectiveness was 6 cases (5.9％),pad using was 13 patients (12.9％),vaginal mesh exposure and erosion was 2 patients(2.0％),the sexual life postoperatively was affected in 8 patients (7.9％).Conclusions TVT-O treatment of SUI is not only easy to operate but also has clinically high security,few complications,low recurrence rate,and significantly improved patients' living quantities.However,patch compli cations can not be ignored and need further discussion.

Objective To develop the human colon carcinoma(HT-29) liver metastasis model in nude mice,and to detect the expression of human telomerase reverse transcriptases(hTERT) mRNA in liver of nude mice. Methods Liver metastases were established in 30 Balb/c nude mice by intrasplenic injection of colonic cancer cells(HT-29),and the spleens were resected.After being sacrificed,the tumor growth was observed,and the pathological examinations were performed.The expression of hTERT mRNA in the livers of nude mice was detected by RT-PCR technique. ResultsHuman colon carcinoma(HT-29) liver metastasis model was developed in all the 30 nude mice,with the liver metastasis rate of 100%.The pathological results revealed the occurrence of liver metastases,and the expression of hTERT mRNA was positive in the liver tissues. Conclusion Intrasplenic injection of HT-29 cell is a reliable way for producing colonic cancer liver metastasis model,and the positive expression of hTERT mRNA in liver tissues indicates the significance of hTERT in the early diagnosis and treatment of colon carcinoma liver metastasis.

Objective To study the relationship among static and dynamic position sense of lower extremity, physical function, and static and dynamic balance in patients with knee osteoarthritis. Methods 32 patients with knee osteoarthritis were tested with Lequesne Index, static and dynamic position sense of lower extremity, and fall risk of static and dynamic balance, and analyzed with Pearson correlation coefficient. Results The medium-to-high-frequency in postural sway correlated with Lequesne Index (r=0.36, P<0.05) and fall risk index of static balance (r=0.85, P<0.001), but not with the fall risk index of dynamic balance (r=0.30, P>0.05). The reposition accuracy error of the unaffected/ mild-affected lower extremity and affected/severe-affected lower extremity correlated with Lequesne Index (r=0.33~0.39, P<0.05), the fall risk index of static (r=0.38~0.45, P<0.05) and dynamic balance (r=0.65~0.70, P<0.05). Conclusion Lower extremity dysfunction post knee osteoarthritis would result in poor proprioception that maintains balance.

Objective To explore the feature of balance function and falling risk in the elderly knee osteoarthritis patients with single knee pain or double knees pain. Methods 30 elderly knee osteoarthritis patients without pain, 30 with single knee pain and 32 with double knees pain were tested with timed up and go test (TUG), postural stability (PS), limits of stability (LOS) and dynamic fall index (DFI). Results There was significant difference in the elderly between no pain and single or double knee pain (P<0.05) in TUG, but not between the single knee pain and double knees pain (P>0.05). There was no significant difference in the elderly between single knee pain and no pain (P>0.05) in PS, but was between double knees pain and the other 2 groups (P<0.05). There was significant difference between no pain and single or double knee pain (P<0.05) in LOS, but not between single knee pain and double knees pain (P>0.05). There was significant difference between no pain and single or double knee pain (P<0.05) in DFI, and between single knee pain and double knees pain (P<0.05). Conclusion The elderly osteoarthritis patients with single knee pain are in high falling risk with their dynamic balance injury, while those with double knees pain are in higher falling risk with their static and dynamic balance injury.

Objective To explore if the treatments with the diclofenac diethylamine emulge import by pulsed ultrasound, massage therapy and quadriceps muscle strengthen training can promote the recovery of prorpioception in patients with knee osteoarthritis. Methods On the basis of health education, 30 elderly patients aged 60 or over with knee osteoarthritis were accepted treatments with 10 times of diclofenac diethylamine emulge import by pulsed ultrasound, 6 times of massage therapy in 2 weeks, and quadriceps muscle strengthen training once or twice a day. Results There were significant differences in the scores of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the maximum isometric extension strength of involved knees, the average isometric extension strength of involved knees and the reposition accuracy error mean of involved knees before and after the treatments (P<0.05). Conclusion The treatments with the diclofenac diethylamine emulge import by pulsed ultrasound, massage therapy and quadriceps muscle strengthen training can not only play a therapeutic effect and shorten the duration of treatment, but also promote the recovery of proprioception in subjects with knee osteoarthritis significantly.