1.Sexual problems during early postpartum period and awareness in postpartum sexual health: a retrospective study
Ruilian SHE ; Xiaoping WEI ; Fang WANG ; Yang WANG ; Fangming SU
Chinese Journal of Health Management 2011;05(4):218-220
Objective To investigate the sexual problems during early postpartum period and the awareness of postpartum sexual health. Methods A questionnaire survey was carried out in 109 women who received routine postpartum check-up in our outpatient department between October and November 2010 to identify postpartum sexual problems and the awareness of postpartum sexual health. Results The first postpartum check-up was received 6 to 12 weeks after the delivery. Of 109 participants,6 (5.5%), 17(15.6%) and 46 (42.2%) resumed sexual activity within 6,6 to 8,and 12 weeks after the delivery,respectively. Postpartum sexual problems included dyspareunia (35/46,76. 09% ), vaginal dryness (29/46,63.04% ), hypoactive sexual desire (25/46,54. 35% ) and lack of orgasm ( 11/46,23.91% ). 10. 87% (5/46)took contraceptive measures,21.10% (23/109) understood the appropriate time to resume sexual activity, 12. 84% (14/109) was aware of the possible postpartum sexual problems, 13.76% (15/109) knew how to avoid pregnant,6.42% (7/109) would visit a doctor in case of the sexual disorders,and 9. 17%(10/109) hoped that their husband know about sexual health. Conclusion Postpartum sexual problems may be common and maternal awareness of postpartum sexual health could be low.
2.The research progress of dynamic combinatorial chemistry.
Wei HE ; Pengwei SHE ; Zheng FANG ; Kai GUO
Acta Pharmaceutica Sinica 2013;48(6):814-23
As a novel branch of combinational chemistry, dynamic combinatorial chemistry (DCC) can be viewed as a technique which combines library synthesis and screening in one pot. By addition of molecular target, ligangds, which show binding affinity or strong interaction with the molecular target, can be amplified an young but rapidly growing branch of combinatorial chemistry, has been widely used in organic chemistry, biochemistry, material fields. Ligands in the library can be amplified, since synthesis of the library is screened by a molecular target. Therefore, these structures could be identified easily. Consequently DCC has been widely used in the lead discovery, material chemistry and other fields. On the basis of the principle and method of DCC, this review emphasizes the three factors of DCC, including molecular targets (bio-enzyme, lectin, nucleic acid, organic molecule, inorganic molecule); reaction (disulphide chemistry, ammoniation reduction reaction, hydrazone chemistry, etc.) and analytical method. Meanwhile, limitation, current situation and future development of DCC were also discussed in this paper.
3.Prognostic analysis of CO₂ laser surgery for early glottic cancer with anterior commissure involvement.
Suzhen SHE ; Binquan WANG ; Ying LI ; Wei GAO ; Yan FENG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(24):2121-2125
OBJECTIVE:
To systematically analyze the local recurrence of CO₂ laser surgery for early glottic cancer and without anterior commissure involvement.
METHOD:
By searching CBM, CNKI, wanfang, weipu, PubMed, Embase, OVID, and Springer database, the retrospective clinical studies were included according to inclusion and exclusion criteria. Meta analysis of extracted data was carried out by RevMan 5.0 software.
RESULT:
By analyzing the 1900 cases from 14 retrospective studies using Meta analysis, it was indicated that local recurrence rate of AC+ group was significantly higher than that of AC- group [OR = 3.00, 95% CI (2.31, 3.89), P < 0.01] for early glottic cancer. Local recurrence rates between AC+ group and AC- group for glottic cancer of Tis and T₁b stage showed no statistically significant difference, while those for glottic cancer of T₁a and T₂ stage showed statistically significant difference.
CONCUSION
Local recurrence rate of CO₂laser surgery for early glottic cancer was related with anterior commissure involvement.
Carbon Dioxide
;
Databases, Factual
;
Glottis
;
pathology
;
Humans
;
Laryngeal Neoplasms
;
surgery
;
Laser Therapy
;
Neoplasm Recurrence, Local
;
Retrospective Studies
4.Lingual thyroglossal duct cyst treatment by low temperature coblation on endoscope.
Jingjing ZHANG ; Qingfeng ZHANG ; Cuiping SHE ; Wei SONG ; Delong LIU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(4):249-251
OBJECTIVE:
To investigate the treatment for lingual thyroglossal duct cyst by low temperature coblation on endoscope.
METHOD:
Eleven cases of lingual thyroglossal duct cyst were treated by low temperature coblation on endoscope,to observe the curative effect and complication.
RESULT:
Eleven cases of lingual thyroglossal duct cyst were satisfied after operation, without serious complication. There were no recurrence during a followed up for 1-3 years after operation.
CONCLUSION
The operation for lingual thyroglossal duct cyst by low temperature coblation on endoscope was easy,safe and effective.
Adolescent
;
Adult
;
Child
;
Child, Preschool
;
Cold Temperature
;
Endoscopes
;
Female
;
Humans
;
Male
;
Middle Aged
;
Thyroglossal Cyst
;
surgery
;
Young Adult
5.Clinical observation of coblation under endoscopy on epiglottis cyst.
Nannan ZHANG ; Qingfeng ZHANG ; Delong LIU ; Cuiping SHE ; Wei SONG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(19):1514-1516
OBJECTIVE:
To evaluate the effect of the coblation under endoscopy on epiglottis cyst.
METHOD:
One hundred and ninety-three patients with epiglottis cyst were treated with coblation under endoscopy. Follow-up study was performed from 1 month to 6 months after treatments.
RESULT:
All 193 cases with epiglottis cyst were primary cured without serious complication and the cure rate was 100%. Moreover, the minor hemorrhage (1-5 ml) was observed.
CONCLUSION
The coblation under endoscopy on epiglottis cyst was safe, effective and minimally invasive.
Cysts
;
surgery
;
Endoscopy
;
Epiglottis
;
Follow-Up Studies
;
Humans
;
Laryngeal Diseases
;
surgery
6.A preliminary study on the superiority of using of coblation during the maxillary sinus operation.
Chenjing CHENG ; Qingfeng ZHANG ; Cuiping SHE ; Wei SONG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(15):1363-1366
OBJECTIVE:
Observed the using of coblation during the maxillary sinus operation, to investigate the superiority of its clinical application.
METHOD:
Selecting 46 patients with the maxillary sinus lesions of sinusitis, nasal polyps and nasal inverted papilloma as research objects, the control group used high speed cutting drill, the research group used coblation separately for functional endoscopic sinus surgery. Six months postoperative follow-up, observeing the subjective symptoms and objective examination.
RESULT:
Subjective symptoms and objective examination scores of two groups of patients improved significantly. Compared with the control group, the operation time, bleeding volume and postoperative examination time are reduced in the study group of patients. Endoscopic examinations of the study group are better than the control group.
CONCLUSION
Using coblation for the maxillary sinus operation, treatment are more thorough, more minimally invasive, shorten operation time, reduce bleeding and recheck time after surgery, is worthy of clinical use.
Endoscopy
;
Humans
;
Maxillary Sinus
;
surgery
;
Nasal Polyps
;
surgery
;
Nasal Surgical Procedures
;
methods
;
Papilloma, Inverted
;
surgery
;
Postoperative Period
;
Sinusitis
;
surgery
7.Clinical, significance of the nomenclature for nasal septum tail: A preliminary study.
Qingfeng ZHANG ; Nannan ZHANG ; Cuiping SHE ; Wei SONG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(15):1358-1359
OBJECTIVE:
To observe and summarize the abnormal morphological appearance of nasal septum tail during adenoidectomies, and to have a preliminary study on its clinical significance.
METHOD:
One hundred and eighty-three children were shown with abnormality on nasal septum tail in 2892 cases with adenoid hypertrophy who received adenoidectomies in our department.
RESULT:
The abnormalities of nasal septum tail can be classified into two types: del tails and columnar ones. All children suffered from nasal septum tail received radiofrequency ablation and all had a good postoperative recovery.
CONCLUSION
The presence of these two types of nasal septum tail may be related to adenoid hypertrophy, adenoiditis, sinusitis, and some congenital malformations.
Adenoidectomy
;
Adenoids
;
pathology
;
Catheter Ablation
;
Child
;
Humans
;
Hypertrophy
;
Nasal Septum
;
abnormalities
;
Sinusitis
;
pathology
8.Nasal mucosa recovery after endoscopic surgery using the plasma radiofrequency ablation at low temperature for treatment of nasal inverted papilloma.
Qingfeng ZHANG ; Cuiping SHE ; Wei SONG ; Shulin CUI
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(8):520-522
OBJECTIVE:
To assess the therapeutic effect and study the role of nasal mucosa epithelization after endoscopic surgery using the plasma radiofrequency ablation at low temperature in patients with nasal inverted papilloma.
METHOD:
The clinical data of 104 patients with nasal inverted papilloma underwent endoscopic surgery u sing the plasma radiofrequency ablation at low temperature from July, 2008 to July, 2012 were analyzed,and the recovery of mucosa was observed under nasal endoscope.
RESULT:
The mucosa recovery extent showed a decreasing trend from mucosa pattern degree I to III, where the difference was statistically significant by chi-square test between groups (P < 0.05). The average epithelialization time was 2.7 months. It showed a significantly decreasing trend among average epithelialization time of different degrees of mucosa (P < 0.05). The nasal mucosa of most patients completed epithelialization 2.9 months after surgery.
CONCLUSION
It is safe and effective to treat nasal inverted papilloma with plasma radiofrequency ablation at low temperature. The patients should be followed up with regular reexamination for at least three months after surgery.
Adult
;
Aged
;
Aged, 80 and over
;
Catheter Ablation
;
Endoscopy
;
Female
;
Humans
;
Male
;
Middle Aged
;
Nasal Cavity
;
Nasal Mucosa
;
pathology
;
Nose Neoplasms
;
surgery
;
Papilloma, Inverted
;
surgery
;
Postoperative Period
;
Retrospective Studies
10. Effect of xiaozhong sanyu pills on brain edema in rats with intracerebral hemorrhage
Medical Journal of Chinese People's Liberation Army 2014;39(11):868-871
Objective To observe the effect of Xiaozhong Sanyu pills (XZSY) on neurological severity score (NSS), brain water content and expression level of water channel aquaporin 4 (AQP4) in rats with intracerebral hemorrhage (ICH). Methods ICH model was reproduced by Rosenberg method in 150 SD rats, then the animals were randomly divided into model group (n=50), XZSY high dose group (n=50, 40 mg/kg of XZSY suspension was given by intragastric administration, bid) and XZSY low dose group (n=50, 20 mg/kg of XZSY suspension was given by intragastric administration, bid), and the latter two groups were further randomly divided into 12-h and 1-, 3-, 7-, and 10-d subgroups. The differences in NSS, brain water content and expression level of AQP4 among 3 groups were analyzed. Results Compared with control group, the NSS, brain water content and expression level of AQP4 were lowered at 3, 7 and 10 d in XZSY low dose group, and lowered at 1, 3, 7 and 10 d in XZSY high dose group (P<0.05, P<0.01). Compared with XZSY low dose group, the NSS and brain water content were lowered on 7 and 10 d, and expression level of AQP4 was lowered at 3, 7 and 10 d in XZSY high dose group (P<0.05, P<0.01). Conclusion Early administration of XZSY could reduce the expression of AQP4 after cerebral hemorrhage, and accordingly alleviate the intracellular edema and improve the prognosis of ICH.