1.On training clinical medical postgraduate students
Chinese Journal of Medical Education Research 2002;0(01):-
Objective To probe the essential aspect and its counter measure in training clinical medical postgraduate students.Methods Based on the review of recently publish papers related and teaching practice for years,the standpoint is put on the need of students in their long-term career after receiving degree.Results Medical ethics and medical information education should be the key point in the teaching plan.Teaching the students in accordance with their apti-tude should be based on their long-term need and the supervisors should be glad for and skilful at education.To put more cost of scientific research to students is in keeping with the China’s na-tional policy of invigorating the country through science and technology.Writing clinical case reports ought to be encouraged.Conclusion The noble medical ethics is the motivation force of gaining consummate medical skill.Up-to-date medical information and skill are the necessary capability in getting new knowledge and bringing forth new ideas.Writing case reports is to keep with the reality of students and may deepen the results of clinical observation and accumulate more data on typical case as well as give the bases to further research.
2.Multifactorial analysis on prognosis of acute peripheral arterial embolization
Journal of Chongqing Medical University 1987;0(01):-
Objective:To evaluate the prognosis of acute peripheral arterial embolization.Methods:From Jan 1990 to Jun 2002,117 cases with 149 times of embolization were analyzed retrospectively to determine the distribution,amputation rate and mortality of arterial embolization.Logistic regression was employed to define the role of site,the extent and range of ischemia,ischemic time,treatment modality,with or without atherosclerosis,and recurrent onset on amputation rate of extremities.Results:Approximately 87% of embolization occurred in lower limbs,that occuring in internal organ was about 2% and upper extremities 10%.Among 117 cases,the mortality was 11.9%,amputation rate 7.8% and limb salvage 92.2%.Conclusion:Underlying heart disease and embolization of internal principal organ are the leading causes of death.Single embolectomy and anti-coagulation therapy are the mainstay of treatment for acute embolization.The major prognosis of limbs depended on the extent and range of ischemia and secondary treatment.
3.Radiofrequency ablation for the treatment of recurrent hepatocellular carcinoma:analysis of the therapeutic results and prognostic factors
Journal of Interventional Radiology 2015;(10):923-927
Based on both domestic and abroad research results concerning the local therapeutic efficacy, influence factors, survival time and prognosis of radiofrequency ablation (RFA) in treating recurrent hepatocellular carcinoma (HCC), this paper aims to make a review of medical literatures about RFA treatment of recurrent HCC that were published in Chinese and in English during the period from 2005 to 2014, and to analyze the related factors that may influence the local therapeutic efficacy and survival rate. The results indicate that the recurrent tumor size, tumor number, recurrence interval, serum alpha fetoprotein (AFP) level, serum prothrombin, etc. are important factors that will affect the therapeutic efficacy of recurrent HCC. At the same time, the results point out that the study of imaging predictors can help suggest the different recurrent types, which is very useful in making individualized follow-up strategy and in monitoring tumor recurrence. Local treatment, with RFA being the main method, together with comprehensive therapies, including other new technologies and new drugs, will improve the current clinical situation in treating recurrent HCC.
4.Experience of Clinical Pharmacists Participating in the Treatment of One Senior Patient with Acute Cholangitis by Biapenem
China Pharmacist 2017;20(4):700-702
Objective:To provide ideas for the participation of clinical pharmacists in clinical individualized medication.Methods:Clinical pharmacists participated in the clinical consultation for one senior patient with acute cholangitis treated with biapenem.Results:The consultation comments and suggestions proposed by clinical pharmacists were accepted by clinics,which played an important role in assisting doctors in the rational drug use and significantly improved the medical treatment.Conclusion:Clinical pharmacists should participate in individualized medication and help clinicians optimize drug therapy,which can improve the safety and efficacy of medication.
5.Alteration of level of panel reactive antibodies, TGF-βin serum and expression rate of nTreg cells in peripheral blood in women with unexplained recurrent spontaneous abortion after immunotherapy
Chinese Journal of Immunology 2015;(6):831-834
Objective: To investigate the effects of immunotherapy on PRA, TGF-β and CD4+CD25+Foxp3+ nTreg cells in women with unexplained recurrent spontaneous abortion. Methods:We detect the level of PRA,TGF-βin serum and the expression of nTreg cells in peripheral blood of pregnant, non pregnant and natural fertility women by enzyme immunoassay and flow cytometry. Results:After immunotherapy,the median level of PRA and TGF-βin non pregnant group was lower than that in pregnant group(27. 5%,107. 7 pg/L vs 68. 75%,189. 9 pg/L,P<0. 01). Compared to pregnant group,the median expression rate of nTreg cells were lower in non pregnant group(5. 05% vs 8. 05%,P<0. 01). Conclusion:The PRA,TGF-βand nTreg cells are critical factors for pregnancy in RSA patients. It is helpful to identify and judge the effect of immunotherapy by detect the level of panel reactive antibodies,TGF-β in serum and the expression rate of nTreg cells in peripheral blood.
6.New immunosupressants in the treatment of thyroid-associated ophthalmopathy
Chinese Journal of Endocrinology and Metabolism 2013;29(11):995-997
Thyroid-associated ophthalmopathy (TAO) is an inflammatory eye disease associated with thyroid autoimmune disorder.The traditional treatments have yielded limited efficacy but with some side effects.Recently,researches have shown that some new immunosupressants may be used for the treatment of TAO with significantly improved symptoms,and reduction in clinical activity score.
7.Effects of Bevacizumab on the proliferation and epithelial-mesenchymal transition in human retinal pigment epithelial cells in vitro
International Eye Science 2016;16(8):1449-1452
?AIM:To investigate the effects of Bevacizumab on the proliferation and the expression of E -Cadherin and fibronectin in human retinal pigment epithelial cell ( ARPE-19) in vitro.?METHODS: Different concentrations (0, 0.625, 1.25, 2.5, 5.0mg/mL) of bevacizumab were exposed to ARPE-19 cells, then cell viability was analyzed by CCK-8, cell cycle was determined by flow cytometry, and the expression of E-Cadherin and fibornectin was detected by Western blot and RT-PCR.?RESULTS:The concentration as 2.5mg/mL or 5.0mg/mL of bevacizumab was shown to effectively suppress the proliferation and cell cycle of ARPE-19 cell (P<0.05). In addition, 2.5mg/mL or 5.0mg/mL of bevacizumab could downregulate the expression of E-cadherin and promote the transcription of fibronection gene (P<0.05).?CONCLUSION:High concentration of bevacizumab was able to inhibit ARPE-19 proliferation, downregulate E-Cadherin expression and promote fibronectin expression, indicating epithelial-mesenchymal transition induced by bevacizumab in ARPE-19 cell.
8.Investigation on Formaldehyde Pollution Caused by Furniture in Tunnel
Journal of Environment and Health 2007;0(07):-
Objective To investigate the formaldehyde pollution in a tunnel. Methods The concentration of formaldehyde was determined in rooms for different function,in rooms with different number of furniture,in different position in a tunnel and at different time of using air cleaner in Oct. 2006. Results The total rate of exceed standard of formaldehyde level in the tunnel was 82.9%,the rate of exceed standard in the rooms disposed by all the furniture was 100%,the rate of exceed standard in the front of the tunnel was lowest (63.6%). Using the air cleaner,the rate of exceed standard decreased in degree. Conclusion The main source of formaldehyde pollution in a tunnel is furniture,formaldehyde is the main air pollutant in a tunnel.
9.Clinical application of CyberKnife for the treatment of intracranial and extracranial tumors
China Oncology 2006;0(12):-
CyberKnife is a newly developed technology in the field of stereotactic radiosurgery/radiotherapy(SRS/SRT).Compared with conventional SRS/SRT,there are many advantages for CyberKnife in terms of being real-time image-guided,frameless,highly accurate,etc.Recently,it has been used to treat different types of malignant carcinoma including intracranial and extracranial tumors.This article summarized the contemporary progress of CyberKnife in the treatment of intracranial and extracranial tumors.
10.Prediction of prostate cancer by logistic regression model about patient's age and transrectal ultrasound characteristics combined with serum PSA level
Chinese Journal of Biochemical Pharmaceutics 2014;37(7):114-116,119
Objective To construct a logistic regression model about the patients' age and transrectal ultrasound characteristics combined with serum PSA level and to predict prostate cancer.Methods 424 clinical data of patients with prostate disease in our hospital from January 2011 to January 2014 were retrospectively analyzed,the patients' age ,transrectal ultrasound pathological findings and biopsy findings in patients were used to establish a logistic regression model.Results Compared to patients with prostate cancer by age segment,>70 years of age or PSA levels in patients was significantly higher than in patients with other age groups;prostate cancer patients and patients with non-cancerous prostate disease were significant differences in the comparison of the various PSA levels (P<0.05);shape of two groups of patients with prostate,prostate boundaries,both inside and outside the boundaries gland,prostate and seminal vesicles separation line clarity,prostate and rectum separation line definition,lymph node metastasis, abnormal blood flow signals and weak echo comparison with a statistically significant difference between two groups(P<0.05 ),whereas no significant difference between nodules and uneven echo two factors (P>0.05 );transrectal ultrasonographic combined age and PSA prostate cancer diagnosis sensitivity of 65.01% and a specificity of 92.73% and accuracy was 83.46%,81.89% positive predictive value,negative predictive value 83.95%. Conclusion Age and characteristics of patients with rectal ultrasound combined with serum PSA level logistic regression model to predict the results of the prostate is better,and should be introduced.