1. Convalescent plasma: A potential therapeutic option for COVID-19 patients
Swee Li NG ; Bey Hing GOH ; Tsuey Ning SOON ; Wei Hsum YAP ; Yin-Quan TANG ; Kai Bin LIEW ; Ya Chee LIM ; Long Chiau MING ; Bey Hing GOH
Asian Pacific Journal of Tropical Medicine 2020;13(11):477-486
The new coronavirus disease (COVID-19) outbreak has challenged us to take unprecedented steps to bring this pandemic under control. In view of the urgency of this situation, convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current pandemic. This is mainly due to the fact that convalescent plasma has been studied in a few case series with promising outcomes. In addition, on-going large clinical trials aimed to further evaluate the effectiveness, safety, and optimal dosage, duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising results. Therefore, this article aims to provide an overview of possible mechanisms of actions of convalescent plasma, its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.
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