Objective The purpose of this study was to examine the effects of exercise training on cardiac function and automatic nervous activity in patients with coronary artery disease(CAD) following PTCA or intracoronary stent implantation. Methods For this study, 37 CAD patients (28 men and 9 women; aged 56.23 ?11.16 years) participated in a supervised 8-week training program with 35 healthy controls(27 men and 8 women; aged 55.72 ?10.34 years). Cardiac function was assessed with indexes obtained during exercise testing using the standard Bruce protocol (submaximal gradural treadmill exercise) before and after 8 weeks training. Meanwhile, heart rate variability (HRV) was used to value the automatic nervous activity. Results After 8 weeks, the margin between maximal HR and resting HR (△HR=HR max-HR resting) was significantly broader (P

The discipline of nutrition has been developing quickly in the past 30 years in China,and a number of scientific progress has been achieved.Some new discoveries have been unveiled in terms of treatment and prevention of liver carcinoma,colon cancer,and breast cancer by certain nutrients.Besides,the application of nutrition in the prevention and treatlnents of metabolic diseases such as obesity.diabetes mellitus and congenital malfcIrmation has been studied.Furthermore,academic achievements in the treatment of tumor and metabolic diseases by integrating nutritional therapies has also been made.The establishment of relevant organizations and institutes as well as the prosperous performance of nutrition education contribute to the development of discipline of nutrition in China.

Child Nutrition Sciences ; Health Knowledge, Attitudes, Practice ; Humans ; Physicians

AIM: To observe the effects of Yangxue qingnao-containing serum on rat vascular smooth muscle cell (VSMC) proliferation induced by lysophosphatidic acid (LPA). METHODS: The [ 3H]-TdR incorporation and mitogen-activated protein kinasc (MAPK) activity were measured in cultured VSMC. End product of lipid peroxidation-MDA levels were also detected. RESULTS: 1?10 -9 ,1?10 -8 and 1?10 -7 mol/L LPA enhanced the cultured VSMC [ 3H]-TdR incorporation, increased MAPK activity and MDA content in a concentration-dependent manner. 5%, 10% and 15% Yangxue qingnao-containing serum concentration-dependently inhibited the increase in VSMC [ 3H]-TdR incorporation, MAPK activity and MDA content induced by LPA. CONCLUSIONS: LPA has a stimulating effect on VSMC proliferation. The LPA-induced intracellular signal transduction may be related to MAPK activity. Yangxue qingnao can efficiently inhibit LPA -induced VSMC proliferation,MAPK activity and lipid peroxidation. [

Integrin is a main factor that mediates adhesive attraction between the cell and the extracellular matrix,and it participates in the formation of new vessel lumens and the construction of the rete vasculosum by regulating endothelial cell adhesion and migration.The extracellular matrix is the ligand of integrin.Collagen and laminin's deposition form new vessel lumens.The vascular endothelial growth factor promotes the proliferation of endothelial cells,accelerates angiogenesis and increases the permeability of blood vessels.This review focuses on the roles and correlation of integrin and VEGF in angiogenesis.

BACKGROUND:White blood cells involved in the inflammatory response play an important role in deep vein thrombosis.E-selectin mediates the initial process of white blood cell and vascular endothelial cell attachment during inflammation.OBJECTIVE:To investigate the relationship between deep venous thrombosis(DVT) and plasma E-selectin.DESIGN,TIME AND SETTING:Completely random design and linear correlation analysis were performed at Department of Vascular Surgery,First Affiliated Hospital of Chongqing Medical University and Clinical Diagnostic Laboratory of Chongqing Medical University from September to December 2007.PARTICIPANTS:Twenty-seven cases of deep vein thrombosis,16 males and 11 females with an average age of(57 ? 15) years,were selected,who attacked within 3 days or with aggregated condition.METHODS:Blood samples were obtained at the admission of the patients.After 72 hours,a second specimen was obtained,defined by thrombolysis and anticoagulant therapy.Determination of plasma E-selectin by ELISA and the blood coagulation abilities and platelet count of the 1st blood samples were performed,including part-time activation thromboplastin,prothrombin time,and plasma fibrinogen.MAIN OUTCOME MEASURES:E-selectin levels before and after treatment,blood coagulation abilities before treatment,platelet determination and E-selectin related analysis.RESULTS:No acute pulmonary embolism occurred in 27 cases of deep vein thrombosis during the treatment.One case underwent routine Forgart of thrombectomy catheter,and of the other 26 cases,15 were significantly improved,and 11 were not improved after 72 hours.Plasma E-selectin levels significantly decreased after thrombolysis,anticoagulant therapy in deep vein thrombosis patients with clinical remission(P = 0.001),but the plasma E-selectin levels were increased in those with no remission(P = 0.003).E-selectin levels and platelet count of deep vein thrombosis in patients before treatment showed no correlation(r =-0.113,P = 0.576),and were not related to fibrinogen content(r =-0.050,P = 0.802),or part-time activation thromboplastin(r=-0.046,P=0.822),and prothrombin time(r=-0.080,P=0.690).CONCLUSION:Plasma E-selectin levels are positively related to deep vein thrombosis severity.

Objective To investigate the change of serum resistin levels in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).MethodsPolysomnography(PSG)was performed in 58 patients with OSAHS and in 26 controls without differences in age and BMI.Serum resistin levels were measured by ELISA.Results(1)Serum resistin levels were significantly higher in patients with OSAHS than those in control group.(2)FPG levels were significantly higher in patients with OSAHS than those in control group.(3)TG levels were significantly higher in patients with OSAHS than those in control group.(4)Serum resistin levels were correlated positively with FPG in obesity patients with OSAHS、nonobesity patients with OSAHS and nonbesity controls group.(5)Serum resistin levels were correlated positively with TG in obesity patients with OSAHS、nonobesity patients with OSAHS and nonbesity controls group.(6)Serum resistin levels were correlated positively with BMI in OSAHS.(7)Serum resistin levels were correlated negatively with LSaO2 in OSAHS.(8)Serum resistin levels were correlated positively with AHI in OSAHS.ConclusionDetermination of serum resistin levels may be the predictors of the severity of OSAHS and it also contributes a lot taking measures to prevent and control the OSAHS complication occurrence and reduce the mortality.

Glutamine(Gln) is the most abundant free amino acid in the circulation. However, Gln depletion is obviously increased in critically ill patients. The liver plays a key role in glutamine metabolism since it can either generate or consume Gln. A number of studies have demonstrated that administration of Gln can protect from liver damage during sepsis or chemotherapy. The mechanism may be that glutamine can be more efficiently transported across cell membranes for glutathione synthesis. Supplement of Gln to PN has been proven to maintain intestinal integrity and reduce bacterial translocation. As a gluconeogenic amino acid, Gln can decrease the portal insulin/glucagon ratio and prevent hepatic steatosis through stimulating glucagon secretion.

L-Carnitine plays an essential role in the transfer of long chain fatty acids from the cytoplasm of a cell into the mitochondrion,where they undergo ?-oxidation.Carnitine deficiency is characterized by plasma and tissue carnitine concentrations below those required for the normal functions of the organism,including cardiomyopathy,myopathy,hypoketonemia,hypoglycemia,hyperammonemia.Studies show that supplement of carnitine could improve the clinical symptoms of some diseases.

Peripherally inserted central catheter(PICC) is now often used in pediatric patients.PICC is easily inserted,safe,and cost-effective.Although it has many benefits,physicians and nurses remain acutely aware of the problem involved with placement of PICC lines.This review is about the research progress of PICC line related problems.